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Author Details

Matthias Gstaiger
Institute of Molecular Systems Biology, ETH Zurich
1994
71
41
PMIDPaper TitleJournal TitlePublished Year
36896621Phosphorylation-linked complex profiling identifies assemblies required for Hippo signal integration.Mol Syst Biol2023
37558949Target Deconvolution by Limited Proteolysis Coupled to Mass Spectrometry.Methods Mol Biol2023
36179048Novel biochemical, structural, and systems insights into inflammatory signaling revealed by contextual interaction proteomics.Proc Natl Acad Sci U S A2022
35353516Covalent Proximity Scanning of a Distal Cysteine to Target PI3Kα.J Am Chem Soc2022
33687722System-Wide Profiling of Protein Complexes Via Size Exclusion Chromatography-Mass Spectrometry (SEC-MS).Methods Mol Biol2021
33727531Mapping specificity, cleavage entropy, allosteric changes and substrates of blood proteases in a high-throughput screen.Nat Commun2021
33500549Inhibition of endothelin-B receptor signaling synergizes with MAPK pathway inhibitors in BRAF mutated melanoma.Oncogene2021
33859439PCprophet: a framework for protein complex prediction and differential analysis using proteomic data.Nat Methods2021
32678104Multi-layered proteomic analyses decode compositional and functional effects of cancer mutations on kinase complexes.Nat Commun2020
32027860A Global Screen for Assembly State Changes of the Mitotic Proteome by SEC-SWATH-MS.Cell Syst2020
32690956Complex-centric proteome profiling by SEC-SWATH-MS for the parallel detection of hundreds of protein complexes.Nat Protoc2020
32744500NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.Elife2020
32707033Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.Mol Cell2020
31123282BRAF inhibition sensitizes melanoma cells to α-amanitin via decreased RNA polymerase II assembly.Sci Rep2019
31735627The Leukemogenic TCF3-HLF Complex Rewires Enhancers Driving Cellular Identity and Self-Renewal Conferring EP300 Vulnerability.Cancer Cell2019
31464372Elucidating essential kinases of endothelin signalling by logic modelling of phosphoproteomics data.Mol Syst Biol2019
31189114Quantitative Interactomics in Primary T Cells Provides a Rationale for Concomitant PD-1 and BTLA Coinhibitor Blockade in Cancer Immunotherapy.Cell Rep2019
29599191AP-SWATH Reveals Direct Involvement of VCP/p97 in Integrated Stress Response Signaling Through Facilitating CReP/PPP1R15B Degradation.Mol Cell Proteomics2018
27762135Contribution of Mass Spectrometry-Based Proteomics to the Understanding of TNF-α Signaling.J Proteome Res2017
28355572Precise Temporal Profiling of Signaling Complexes in Primary Cells Using SWATH Mass Spectrometry.Cell Rep2017
28330616Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.Cell Syst2017
28665270Meru couples planar cell polarity with apical-basal polarity during asymmetric cell division.Elife2017
26933192An Inducible Retroviral Expression System for Tandem Affinity Purification Mass-Spectrometry-Based Proteomics Identifies Mixed Lineage Kinase Domain-like Protein (MLKL) as an Heat Shock Protein 90 (HSP90) Client.Mol Cell Proteomics2016
27705803A High-Density Map for Navigating the Human Polycomb Complexome.Cell Rep2016
26960254The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles.Nat Commun2016
26121405Assessment of a method to characterize antibody selectivity and specificity for use in immunoprecipitation.Nat Methods2015
24584089Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub.Nat Immunol2014
23237831A method to resolve the composition of heterogeneous affinity-purified protein complexes assembled around a common protein by chemical cross-linking, gel electrophoresis and mass spectrometry.Nat Protoc2013
24366813Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1.Mol Syst Biol2013
24162925Quantifying protein interaction dynamics by SWATH mass spectrometry: application to the 14-3-3 system.Nat Methods2013
23921808The CRAPome: a contaminant repository for affinity purification-mass spectrometry data.Nat Methods2013
23602568The protein interaction landscape of the human CMGC kinase group.Cell Rep2013
23629968EphA2 cleavage by MT1-MMP triggers single cancer cell invasion via homotypic cell repulsion.J Cell Biol2013
23396353Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition.Nat Struct Mol Biol2013
23455922Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.Nat Methods2013
23529396Genotype-phenotype relationships in light of a modular protein interaction landscape.Mol Biosyst2013
22352807SAINT-MS1: protein-protein interaction scoring using label-free intensity data in affinity purification-mass spectrometry experiments.J Proteome Res2012
23129748Regulation of PTEN activity by p38δ-PKD1 signaling in neutrophils confers inflammatory responses in the lung.J Exp Med2012
22635269Bacterial effector binds host cell adenylyl cyclase to potentiate Gαs-dependent cAMP production.Proc Natl Acad Sci U S A2012
21097556Tandem affinity purification combined with inducible shRNA expression as a tool to study the maturation of macromolecular assemblies.RNA2011
22068330Modularity and hormone sensitivity of the Drosophila melanogaster insulin receptor/target of rapamycin interaction proteome.Mol Syst Biol2011
21822278Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutations.Nat Cell Biol2011
21483450The oxygen sensor PHD3 limits glycolysis under hypoxia via direct binding to pyruvate kinase.Cell Res2011
20797625Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signaling.Mol Cell2010
19211744NSs protein of rift valley fever virus induces the specific degradation of the double-stranded RNA-dependent protein kinase.J Virol2009
19931458The dASPP-dRASSF8 complex regulates cell-cell adhesion during Drosophila retinal morphogenesis.Curr Biol2009
19687803Applying mass spectrometry-based proteomics to genetics, genomics and network biology.Nat Rev Genet2009
19387489Comparative profiling identifies C13orf3 as a component of the Ska complex required for mammalian cell division.EMBO J2009
19156129An integrated workflow for charting the human interaction proteome: insights into the PP2A system.Mol Syst Biol2009
19198594Quantitative interaction proteomics using mass spectrometry.Nat Methods2009
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Collaborators

Ruedi Aebersold
Institute of Molecular Systems Biology, ETH Zurich
Co-authored papers 35
Fabian Frommelt
CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
Co-authored papers 8
Ben C Collins
Queen's University of Belfast
Co-authored papers 7
Federico Uliana
Institute of Biochemistry, ETH Zurich
Co-authored papers 7
Rodolfo Ciuffa
Institute of Molecular Systems Biology, ETH Zurich
Co-authored papers 6
Nicolas Tapon
The Francis Crick Institute
Co-authored papers 5
Martin Mehnert
Institute of Molecular Systems Biology, ETH Zurich
Co-authored papers 4
Andrea Fossati
J. David Gladstone Institutes
Co-authored papers 4
Moritz Heusel
Lund University
Co-authored papers 4
Anne-Claude Gingras
Lunenfeld-Tanenbaum Research Institute
Co-authored papers 3
Alexander Schmidt
Co-authored papers 3
Alexey I Nesvizhskii
University of Michigan ann arbor
Co-authored papers 3
Isabell Bludau
Max-Planck Institute of Biochemistry
Co-authored papers 3
Matthias Peter
Institute of Biochemistry, ETH Zurich
Co-authored papers 3
Christopher M Hovens
Royal Melbourne Hospital, The University of Melbourne
Co-authored papers 3
Brian Raught
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 2
Matej Vizovi??ek
Jozef Stefan Institute
Co-authored papers 2
Bernd Wollscheid
ETH Zurich
Co-authored papers 2
Ludovic Gillet
ETH Zurich
Co-authored papers 2
Markus Müller
Co-authored papers 2
Sabrina Keller
Institute of Molecular Systems Biology, ETH Zurich
Co-authored papers 1
Peter Sykacek
Institute of Computational Biology, University of Natural Resources and Life Sciences
Co-authored papers 1
Lukas N Mueller
Co-authored papers 1
S??ren Matzk
Max Planck Institute for Molecular Genetics
Co-authored papers 1
Marie-Laure Yaspo
Max Planck Institute for Molecular Genetics
Co-authored papers 1
Hans-J??rg Warnatz
Max Planck Institute for Molecular Genetics
Co-authored papers 1
Vincenzo De Filippis
Department of Pharmaceutical and Pharmacological Sciences, University of Padua
Co-authored papers 1
Bruno Lemaitre
Global Health Institute, Ecole Polytechnique Federale de Lausanne (EPFL)
Co-authored papers 1
Chen Li
Biomedicine Discovery Institute, Monash University
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Eivind Salmorin Birkeland
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