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Author Details

E Sigal
Institute of Biochemistry & Cell Biology
1984
52
28
PMIDPaper TitleJournal TitlePublished Year
1158114312/15-Lipoxygenase gene disruption attenuates atherogenesis in LDL receptor-deficient mice.Circulation2001
11164430Interleukin (IL)-4 deficiency does not influence fatty streak formation in C57BL/6 mice.Atherosclerosis2000
10856520The effects of N-6 polyunsaturated fatty acid supplementation on the lipid composition and atherogenesis in mouse models of atherosclerosis.Atherosclerosis2000
10978255Overexpression of 15-lipoxygenase in vascular endothelium accelerates early atherosclerosis in LDL receptor-deficient mice.Arterioscler Thromb Vasc Biol2000
11102797Applied genomics: integration of the technology within pharmaceutical research and development.Curr Opin Biotechnol2000
9669792Hereditary hemochromatosis: gene discovery and its implications for population-based screening.JAMA1998
9465039The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding.Proc Natl Acad Sci U S A1998
9561189A model of arachidonic acid binding for 15-lipoxygenase.Adv Exp Med Biol1997
9224951Characterization and sequence of an additional 15-lipoxygenase transcript and of the human gene.Biochim Biophys Acta1997
9406550The structure of mammalian 15-lipoxygenase reveals similarity to the lipases and the determinants of substrate specificity.Nat Struct Biol1997
8810309Defining the arachidonic acid binding site of human 15-lipoxygenase. Molecular modeling and mutagenesis.J Biol Chem1996
8761181Expression of cyclooxygenase-2 in human and an animal model of rheumatoid arthritis.Br J Rheumatol1996
7479689Conversion of human 15-lipoxygenase to an efficient 12-lipoxygenase: the side-chain geometry of amino acids 417 and 418 determine positional specificity.Protein Eng1995
21232235A possible role for 15-lipoxygenase in atherogenesis.Trends Cardiovasc Med1995
7766617Identification of a specific methionine in mammalian 15-lipoxygenase which is oxygenated by the enzyme product 13-HPODE: dissociation of sulfoxide formation from self-inactivation.Biochemistry1995
7883980Targeting gene expression to the vascular wall in transgenic mice using the murine preproendothelin-1 promoter.J Clin Invest1995
7811740Cloning and characterization of a murine macrophage lipoxygenase.Biochim Biophys Acta1995
7732877Expression of 15-lipoxygenase in transplant coronary artery disease.Adv Prostaglandin Thromboxane Leukot Res1995
7749844Immunohistochemical demonstration of 15-lipoxygenase in transplant coronary artery disease.Arterioscler Thromb Vasc Biol1995
7539577Human 15-lipoxygenase: a potential effector molecule for interleukin-4.Adv Prostaglandin Thromboxane Leukot Res1994
8017770Oxidation, lipoxygenase, and atherogenesis.Ann N Y Acad Sci1994
7825866On the positional specificity of 15-lipoxygenase.Ann N Y Acad Sci1994
7929400Eosinophil 15-lipoxygenase is a leukotriene A4 synthase.J Biol Chem1994
7689566Mechanism of inhibition of cAMP-dependent epithelial chloride secretion by phorbol esters.J Biol Chem1993
8477699Oxygenation of lipoproteins by mammalian lipoxygenases.Eur J Biochem1993
8334154Overexpression, purification and characterization of human recombinant 15-lipoxygenase.Biochim Biophys Acta1993
8358018Human 15-lipoxygenase: induction by interleukin-4 and insights into positional specificity.J Lipid Mediat1993
1539676Cloning and expression of an airway epithelial 12-lipoxygenase.Am J Physiol1992
1566855Cloning of human airway 15-lipoxygenase: identity to the reticulocyte enzyme and expression in epithelium.Am J Physiol1992
1729692Specific inflammatory cytokines regulate the expression of human monocyte 15-lipoxygenase.Proc Natl Acad Sci U S A1992
1636733Cloning and expression of an airway epithelial 12-lipoxygenase.Am J Physiol1992
1899973The molecular biology of mammalian arachidonic acid metabolism.Am J Physiol1991
2010531Gene expression in macrophage-rich human atherosclerotic lesions. 15-lipoxygenase and acetyl low density lipoprotein receptor messenger RNA colocalize with oxidation specific lipid-protein adducts.J Clin Invest1991
2010530Immunocytochemical localization of arachidonate 15-lipoxygenase in erythrocytes, leukocytes, and airway cells.J Clin Invest1991
1944593A primary determinant for lipoxygenase positional specificity.Nature1991
1825549Expression of cloned human 15-lipoxygenase in eukaryotic and prokaryotic systems.Adv Prostaglandin Thromboxane Leukot Res1991
1900682The airway epithelium and arachidonic acid 15-lipoxygenase.Am Rev Respir Dis1991
1696810The expression of active human reticulocyte 15-lipoxygenase in bacteria.Biomed Biochim Acta1990
1698286Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesions.Proc Natl Acad Sci U S A1990
2132526Arachidonate 15-lipoxygenase: immunocytochemical localization in blood and airway cells.Trans Assoc Am Physicians1990
2318885Expression of cloned human reticulocyte 15-lipoxygenase and immunological evidence that 15-lipoxygenases of different cell types are related.J Biol Chem1990
2260964Purification and crystallization of 15-lipoxygenase from rabbit reticulocytes.Biochem Biophys Res Commun1990
2526462Arachidonate 15-lipoxygenase from human leukocytes: purification and structural homology to other mammalian lipoxygenases.Adv Prostaglandin Thromboxane Leukot Res1989
2638524Cloning and expression of human arachidonate 15-lipoxygenase.Trans Assoc Am Physicians1989
2839449An in vivo chemotaxis assay in the dog trachea: evidence for chemotactic activity of 8,15-diHETE.J Appl Physiol (1985)1988
3356688Arachidonate 15-lipoxygenase (omega-6 lipoxygenase) from human leukocytes. Purification and structural homology to other mammalian lipoxygenases.J Biol Chem1988
3415693Inhibition of human leukocyte 5-lipoxygenase by 15-HPETE and related eicosanoids.Biochem Biophys Res Commun1988
3202520Arachidonic acid 15-lipoxygenase and airway epithelium. Biologic effects and enzyme purification.Am Rev Respir Dis1988
3202857Molecular cloning and primary structure of human 15-lipoxygenase.Biochem Biophys Res Commun1988
3337718Arachidonate 15-lipoxygenase from human eosinophil-enriched leukocytes: partial purification and properties.Biochem Biophys Res Commun1988
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Collaborators

Charles S Craik
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 10
Joseph L Witztum
Co-authored papers 2
Amy Ziober
Hospital of the University of Pennsylvania
Co-authored papers 2
Robert J Fletterick
University of California San Francisco
Co-authored papers 2
Charles C Marboe
Co-authored papers 2
Vivette D D'Agati
Columbia University Irving Medical Center
Co-authored papers 2
Nancy Press
Oregon Health and Science University
Co-authored papers 1
Sharon McDonnell
Newcastle upon Tyne NHS Foundation Trust
Co-authored papers 1
Paul C Adams
Western University
Co-authored papers 1
E Clayton
Harvard Medical School, Vanderbilt University, Yale University Yale Law School
Co-authored papers 1
Wylie Burke
The Heart Institute, Cincinnati Children's Hospital Medical Center
Co-authored papers 1
Eric M Meslin
Dalla Lana School of Public Health, University of Toronto
Co-authored papers 1
Robert C Murphy
Co-authored papers 1
Lawrie W Powell
The University of Queensland
Co-authored papers 1
Pamela J Bjorkman
Co-authored papers 1
Francis S Collins
University of Michigan ann arbor
Co-authored papers 1
Peter M Henson
Co-authored papers 1
Elizabeth Thomson
Northrop Grumman Health Solutions
Co-authored papers 1
Ernest Beutler
The Scripps Research Institute
Co-authored papers 1
Michael J Holtzman
Co-authored papers 1
James C Barton
University of Alabama at Birmingham
Co-authored papers 1
Muin J Khoury
Centers for Disease Control and Prevention Atlanta GA USA.
Co-authored papers 1
Benjamin S Wilfond
University of Washington School of Medicine.
Co-authored papers 1
Arno G Motulsky
University of Washington
Co-authored papers 1
Allen Buchanan
University of Arizona
Co-authored papers 1
Christopher K Glass
University of California San Diego
Co-authored papers 1
Mary E Cogswell
Centers for Disease Control and Prevention
Co-authored papers 1
Gary M Brittenham
Columbia University Vagelos College of Physicians and Surgeons
Co-authored papers 1
Release 1.2