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Author Details

Haico van Attikum
Leiden University Medical Center
2001
89
44
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37106138HPF1-dependent histone ADP-ribosylation triggers chromatin relaxation to promote the recruitment of repair factors at sites of DNA damage.Nat Struct Mol Biol2023
37886519DDA1, a novel factor in transcription-coupled repair, modulates CRL4<sup>CSA</sup> dynamics at DNA damage-stalled RNA polymerase II.Res Sq2023
37732274The Fanconi anemia core complex promotes CtIP-dependent end-resection to drive homologous recombination at DNA double-strand breaks.bioRxiv2023
34903604Functional Analysis Identifies Damaging CHEK2 Missense Variants Associated with Increased Cancer Risk.Cancer Res2022
35643632CHEK2 variants: linking functional impact to cancer risk.Trends Cancer2022
36075911Multi-pathway DNA-repair reporters reveal competition between end-joining, single-strand annealing and homologous recombination at Cas9-induced DNA double-strand breaks.Nat Commun2022
35963869XPC-PARP complexes engage the chromatin remodeler ALC1 to catalyze global genome DNA damage repair.Nat Commun2022
35895815Chaperoning of the histone octamer by the acidic domain of DNA repair factor APLF.Sci Adv2022
33811135Characterisation of protein-truncating and missense variants in <i>PALB2</i> in 15 768 women from Malaysia and Singapore.J Med Genet2022
35017203Chl1 helicase controls replication fork progression by regulating dNTP pools.Life Sci Alliance2022
35237296Genomic Reporter Constructs to Monitor Pathway-Specific Repair of DNA Double-Strand Breaks.Front Genet2022
33315086ERCC1 mutations impede DNA damage repair and cause liver and kidney dysfunction in patients.J Exp Med2021
34706224RNF168 E3 ligase participates in ubiquitin signaling and recruitment of SLX4 during DNA crosslink repair.Cell Rep2021
34548335A BRCA1 Coiled-Coil Domain Variant Disrupting PALB2 Interaction Promotes the Development of Mammary Tumors and Confers a Targetable Defect in Homologous Recombination Repair.Cancer Res2021
34772923Zinc finger protein ZNF384 is an adaptor of Ku to DNA during classical non-homologous end-joining.Nat Commun2021
34591877Proteomic analysis identifies novel binding partners of BAP1.PLoS One2021
34140538Epigenetics Identifier screens reveal regulators of chromatin acylation and limited specificity of acylation antibodies.Sci Rep2021
33408245Poly(ADP-ribosyl)ation temporally confines SUMO-dependent ataxin-3 recruitment to control DNA double-strand break repair.J Cell Sci2021
32232336PHF2 regulates homology-directed DNA repair by controlling the resection of DNA double strand breaks.Nucleic Acids Res2020
31782600PHF6 promotes non-homologous end joining and G2 checkpoint recovery.EMBO Rep2020
33195396Functional Characterization of <i>PALB2</i> Variants of Uncertain Significance: Toward Cancer Risk and Therapy Response Prediction.Front Mol Biosci2020
33188175CHD7 and 53BP1 regulate distinct pathways for the re-ligation of DNA double-strand breaks.Nat Commun2020
32865561Loss of ZBTB24 impairs nonhomologous end-joining and class-switch recombination in patients with ICF syndrome.J Exp Med2020
32299836A genetic interaction map centered on cohesin reveals auxiliary factors involved in sister chromatid cohesion in <i>S. cerevisiae</i>.J Cell Sci2020
30651562The CHD6 chromatin remodeler is an oxidative DNA damage response factor.Nat Commun2019
31757951Functional analysis of genetic variants in the high-risk breast cancer susceptibility gene PALB2.Nat Commun2019
31699900Gcn5 and Esa1 function as histone crotonyltransferases to regulate crotonylation-dependent transcription.J Biol Chem2019
31185216Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality.Cancer Cell2019
31421928PARP Inhibitor Resistance: A Tug-of-War in BRCA-Mutated Cells.Trends Cell Biol2019
31476573Bon voyage: A transcriptional journey around DNA breaks.DNA Repair (Amst)2019
31048545WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.Genes Dev2019
29531219TRiC controls transcription resumption after UV damage by regulating Cockayne syndrome protein A.Nat Commun2018
29891926Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48.Nat Commun2018
30022168The shieldin complex mediates 53BP1-dependent DNA repair.Nature2018
30203048Dot1 promotes H2B ubiquitination by a methyltransferase-independent mechanism.Nucleic Acids Res2018
29894693Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality.Cancer Cell2018
28918024Antisense Oligonucleotide-Mediated Removal of the Polyglutamine Repeat in Spinocerebellar Ataxia Type 3 Mice.Mol Ther Nucleic Acids2017
28275011Ataxin-3 consolidates the MDC1-dependent DNA double-strand break response by counteracting the SUMO-targeted ubiquitin ligase RNF4.EMBO J2017
28240985A PALB2-interacting domain in RNF168 couples homologous recombination to DNA break-induced chromatin ubiquitylation.Elife2017
29182755Meta-analysis of DNA double-strand break response kinetics.Nucleic Acids Res2017
28847822DNA repair goes hip-hop: SMARCA and CHD chromatin remodellers join the break dance.Philos Trans R Soc Lond B Biol Sci2017
26895424PARP1 Links CHD2-Mediated Chromatin Expansion and H3.3 Deposition to DNA Repair by Non-homologous End-Joining.Mol Cell2016
26628622Spatiotemporal regulation of posttranslational modifications in the DNA damage response.EMBO J2016
26673702The de-ubiquitylating enzymes USP26 and USP37 regulate homologous recombination by counteracting RAP80.Nucleic Acids Res2016
27732854ZMYND8 Co-localizes with NuRD on Target Genes and Regulates Poly(ADP-Ribose)-Dependent Recruitment of GATAD2A/NuRD to Sites of DNA Damage.Cell Rep2016
27731380Antisense oligonucleotide-mediated exon skipping as a strategy to reduce proteolytic cleavage of ataxin-3.Sci Rep2016
27453043A Network of Conserved Synthetic Lethal Interactions for Exploration of Precision Cancer Therapy.Mol Cell2016
27233470Functional Analysis of Missense Variants in the Putative Breast Cancer Susceptibility Gene XRCC2.Hum Mutat2016
25533186Yeast PP4 interacts with ATR homolog Ddc2-Mec1 and regulates checkpoint signaling.Mol Cell2015
26437225Chemogenetic profiling identifies RAD17 as synthetically lethal with checkpoint kinase inhibition.Oncotarget2015
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Collaborators

Susan M Gasser
L'Institut Suisse de Recherche Experimentale sur le Cancer (ISREC) Foundation
Co-authored papers 9
Trey Ideker (CM4AI)
University of California San Diego
Co-authored papers 9
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Amgen Inc.
Co-authored papers 7
Fred van Leeuwen
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Co-authored papers 6
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CNRS, Universite de Toulouse
Co-authored papers 6
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Leiden University Medical Center
Co-authored papers 5
Su Ming Sun
Leiden University Medical Center
Co-authored papers 5
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Oncode Institute, Netherlands Cancer Institute
Co-authored papers 4
Katherine Licon
University of California San Diego
Co-authored papers 4
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 4
Leonie Kollenstart
Leiden University Medical Center
Co-authored papers 3
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Leiden University Medical Center
Co-authored papers 3
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Blavatnik Institute, Harvard Medical School
Co-authored papers 3
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Netherlands Cancer Institute
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University of California
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University of California San Diego
Co-authored papers 2
Huwate Yeerna
Moores Cancer Center, University of California
Co-authored papers 2
Mireille Tittel-Elmer
Geneva University Hospitals
Co-authored papers 2
Lodewyk F A Wessels
University Medical Centre Mannheim, University of Heidelberg
Co-authored papers 2
Amandine Batt??
Center for Integrative Genomics, University of Lausanne
Co-authored papers 2
Vignesh Sivaganesh
University of the Sciences
Co-authored papers 2
John Paul Shen
The University of Texas MD Anderson Cancer Center
Co-authored papers 2
Robert W Sobol
University of South Alabama
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Nicole Hustedt
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Jia L Xu
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Release 1.2