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Author Details

Manu Shankar-Hari
King's College London
2003
179
48
PMIDPaper TitleJournal TitlePublished Year
36694432Stimulation of platelet P2Y<sub>1</sub> receptors by different endogenous nucleotides leads to functional selectivity via biased signalling.Br J Pharmacol2024
35972987An Inhaled Galectin-3 Inhibitor in COVID-19 Pneumonitis: A Phase Ib/IIa Randomized Controlled Clinical Trial (DEFINE).Am J Respir Crit Care Med2023
37888913Simvastatin in Critically Ill Patients with Covid-19.N Engl J Med2023
37495364Estimating the attributable fraction of mortality from acute respiratory distress syndrome to inform enrichment in future randomised clinical trials.Thorax2023
37868151A randomised phase 2a study to investigate the effects of blocking interleukin-33 with tozorakimab in patients hospitalised with COVID-19: ACCORD-2.ERJ Open Res2023
37189034Phase 2 randomised placebo-controlled trial of spironolactone and dexamethasone versus dexamethasone in COVID-19 hospitalised patients in Delhi.BMC Infect Dis2023
37085591Causal Bayesian machine learning to assess treatment effect heterogeneity by dexamethasone dose for patients with COVID-19 and severe hypoxemia.Sci Rep2023
37154608Repair of Acute Respiratory Distress Syndrome in COVID-19 by Stromal Cells (REALIST-COVID Trial): A Multicenter, Randomized, Controlled Clinical Trial.Am J Respir Crit Care Med2023
37343697Cross-Linking Mass Spectrometry Uncovers Interactions Between High-Density Lipoproteins and the SARS-CoV-2 Spike Glycoprotein.Mol Cell Proteomics2023
37143141Publisher Correction: The effect of blood pressure on mortality following outâ¿¿ofâ¿¿hospital cardiac arrest: a retrospective cohort study of the United Kingdom Intensive Care National Audit and Research Centre database.Crit Care2023
37039790Effect of Angiotensin-Converting Enzyme Inhibitor and Angiotensin Receptor Blocker Initiation on Organ Support-Free Days in Patients Hospitalized With COVID-19: A Randomized Clinical Trial.JAMA2023
37405876INVESTIGATION INTO P2Y RECEPTOR FUNCTION IN PLATELETS FROM PATIENTS WITH SEPSIS.Shock2023
37167775Major adverse cardiovascular events (MACE) in patients with severe COVID-19 registered in the ISARIC WHO clinical characterization protocol: A prospective, multinational, observational study.J Crit Care2023
37475125Post-acute sequelae of COVID-19: understanding and addressing the burden of multisystem manifestations.Lancet Respir Med2023
36814234Comparison of systemic inflammatory profiles in COVID-19 and community-acquired pneumonia patients: a prospective cohort study.Respir Res2023
36812500Evolving Management Practices for Early Sepsis-induced Hypoperfusion: A Narrative Review.Am J Respir Crit Care Med2023
36435668Airway pressure release ventilation: a survey of UK practice.Br J Anaesth2023
36604745The effect of blood pressure on mortality following out-of-hospital cardiac arrest: a retrospective cohort study of the United Kingdom Intensive Care National Audit and Research Centre database.Crit Care2023
36860553Albumin versus balanced crystalloid for resuscitation in the treatment of sepsis: A protocol for a randomised controlled feasibility study, "ABC-Sepsis".J Intensive Care Soc2023
34253680ARDS subphenotypes: searching for Rorschach among the roentgenograms?Thorax2022
35587274Use of dexmedetomidine for sedation in mechanically ventilated adult ICU patients: a rapid practice guideline.Intensive Care Med2022
35773325Artemisinin inhibits neutrophil and macrophage chemotaxis, cytokine production and NET release.Sci Rep2022
35615235Outcomes of critically ill COVID-19 patients managed in a high-volume severe respiratory failure and ECMO centre in the United Kingdom.J Intensive Care Soc2022
35672834Baseline plasma IL-18 may predict simvastatin treatment response in patients with ARDS: a secondary analysis of the HARP-2 randomised clinical trial.Crit Care2022
35857310SARS-CoV-2-Specific Memory B Cell Responses Are Maintained After Recovery from Natural Infection and Postvaccination.Viral Immunol2022
35718762Protocol for a scoping review of sepsis epidemiology.Syst Rev2022
35562778Repair of acute respiratory distress syndrome by stromal cell administration (REALIST): a structured study protocol for an open-label dose-escalation phase 1 trial followed by a randomised, triple-blind, allocation concealed, placebo-controlled phase 2 trial.Trials2022
35780805Associations of BMI with COVID-19 vaccine uptake, vaccine effectiveness, and risk of severe COVID-19 outcomes after vaccination in England: a population-based cohort study.Lancet Diabetes Endocrinol2022
35715504Redefining critical illness.Nat Med2022
35357623Correction to: Communityâ¿¿acquired hypokalemia in elderly patients: related factors and clinical outcomes.Int Urol Nephrol2022
36600326Role of immunosuppression in an antibiotic stewardship intervention and its association with clinical outcomes and antibiotic use: protocol for an observational study (RISC-sepsis).BMJ Open2022
36556399Butyrate Supplementation Exacerbates Myocardial and Immune Cell Mitochondrial Dysfunction in a Rat Model of Faecal Peritonitis.Life (Basel)2022
36102943Coronavirus disease 2019 subphenotypes and differential treatment response to convalescent plasma in critically ill adults: secondary analyses of a randomized clinical trial.Intensive Care Med2022
35993236Risk of Myocarditis After Sequential Doses of COVID-19 Vaccine and SARS-CoV-2 Infection by Age and Sex.Circulation2022
36033245Cellular and molecular mechanisms of IMMunE dysfunction and Recovery from SEpsis-related critical illness in adults: An observational cohort study (IMMERSE) protocol paper.J Intensive Care Soc2022
36323418Prevalence, risk factors and treatments for post-COVID-19 breathlessness: a systematic review and meta-analysis.Eur Respir Rev2022
36050558Compartmentalisation of immune responses in critical illness: does it matter?Intensive Care Med2022
35315874Effect of Antiplatelet Therapy on Survival and Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial.JAMA2022
35251032Disrupted Peyer's Patch Microanatomy in COVID-19 Including Germinal Centre Atrophy Independent of Local Virus.Front Immunol2022
35152152Randomised controlled trial of intravenous nafamostat mesylate in COVID pneumonitis: Phase 1b/2a experimental study to investigate safety, Pharmacokinetics and Pharmacodynamics.EBioMedicine2022
35064248A guide to immunotherapy for COVID-19.Nat Med2022
35274164Towards a biological definition of ARDS: are treatable traits the solution?Intensive Care Med Exp2022
34907393Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination or SARS-CoV-2 infection.Nat Med2022
35321556Highly Sensitive Lineage Discrimination of SARS-CoV-2 Variants through Allele-Specific Probe PCR.J Clin Microbiol2022
34755842Association of cardiometabolic microRNAs with COVID-19 severity and mortality.Cardiovasc Res2022
33270526Using Bayesian Methods to Augment the Interpretation of Critical Care Trials. An Overview of Theory and Example Reanalysis of the Alveolar Recruitment for Acute Respiratory Distress Syndrome Trial.Am J Respir Crit Care Med2021
33549322Utilising mass cytometry with CD45 barcoding and standardised leucocyte phenotyping for immune trajectory assessment in critically ill patients.Br J Anaesth2021
33488595Current Understanding of Leukocyte Phenotypic and Functional Modulation During Extracorporeal Membrane Oxygenation: A Narrative Review.Front Immunol2021
33621890Initial setting of high-flow nasal oxygen post extubation based on mean inspiratory flow during a spontaneous breathing trial.J Crit Care2021
33819502Changes in temperature management and outcome after out-of-hospital cardiac arrest in United Kingdom intensive care units following publication of the targeted temperature management trial.Resuscitation2021
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Collaborators

Intensive Care National Audit & Research Centre (ICNARC)
Co-authored papers 28
St. Michael's Hospital, University of Toronto
Co-authored papers 17
Imperial College London
Co-authored papers 13
University of Pittsburgh Medical Center
Co-authored papers 13
St. Michael's Hospital
Co-authored papers 10
University of Pittsburgh
Co-authored papers 10
University of California San Francisco
Co-authored papers 9
The George Institute for Global Health
Co-authored papers 8
University of British Columbia
Co-authored papers 7
Universite de Sherbrooke
Co-authored papers 7
St Thomas' Hospital
Co-authored papers 7
King Saud bin Abdulaziz Medical City for Science and Technology
Co-authored papers 6
Universite Laval
Co-authored papers 6
Center for Experimental and Molecular Medicine, University of Amsterdam
Co-authored papers 6
Co-authored papers 6
Washington University
Co-authored papers 5
Berry Consultants LLC
Co-authored papers 5
University of Cambridge
Co-authored papers 5
University of Kansas Medical Center
Co-authored papers 4
Roslin Institute, University of Edinburgh
Co-authored papers 4
UPMC Children's Hospital of Pittsburgh, University of Pittsburgh
Co-authored papers 4
University of Pittsburgh School of Medicine
Co-authored papers 4
Harbor-university of california los angeles Medical Center
Co-authored papers 4
King's College London, Guy's & St Thomas' Hospital
Co-authored papers 3
Kaiser Permanente
Co-authored papers 3
Heart Institute (InCor), Faculdade de Medicina, Universidade de Sao Paulo
Co-authored papers 3
Massachusetts General Hospital, Harvard School of Medicine,
Co-authored papers 3
D'Or Institute for Research and Education, University of Alberta
Co-authored papers 3
Clinical Research, University of Pittsburgh
Co-authored papers 3
European Molecular Biology Laboratory - European Bioinformatics Institute
Co-authored papers 3