Skip to Main Content

Author Details

Lawrence E Goldfinger
Cardeza Foundation for Hematologic Research, Thomas Jefferson University
1998
45
21
PMIDPaper TitleJournal TitlePublished Year
37961544Altered Platelet-Megakaryocyte Endocytosis and Trafficking of Albumin and Fibrinogen in <i>RUNX1</i> Haplodeficiency.medRxiv2023
35839075Defective RAB31-mediated megakaryocytic early endosomal trafficking of VWF, EGFR, and M6PR in RUNX1 deficiency.Blood Adv2022
32838617High-efficiency unassisted transfection of platelets with naked double-stranded miRNAs modulates signal-activated translation and platelet function.Platelets2021
34936674Platelet microRNAs inhibit primary tumor growth via broad modulation of tumor cell mRNA expression in ectopic pancreatic cancer in mice.PLoS One2021
33940593Platelets and extracellular vesicles and their cross talk with cancer.Blood2021
31899801GRK6 regulates the hemostatic response to injury through its rate-limiting effects on GPCR signaling in platelets.Blood Adv2020
29203271Concepts and advances in cancer therapeutic vulnerabilities in RAS membrane targeting.Semin Cancer Biol2019
31257731Horizontal RNA transfer goes deep: platelet consumption and microRNA utilization by vascular smooth muscle cells.J Thromb Haemost2019
31221792GPVI inhibitor as antitumor gateway drug.Blood2019
30787021ELMO1 deficiency enhances platelet function.Blood Adv2019
29564336Platelet Microparticles and miRNA Transfer in Cancer Progression: Many Targets, Modes of Action, and Effects Across Cancer Stages.Front Cardiovasc Med2018
29883056TC21/RRas2 regulates glycoprotein VI-FcRγ-mediated platelet activation and thrombus stability.J Thromb Haemost2018
29632235Defective RAB1B-related megakaryocytic ER-to-Golgi transport in RUNX1 haplodeficiency: impact on von Willebrand factor.Blood Adv2018
28075530Dysregulation of PLDN (pallidin) is a mechanism for platelet dense granule deficiency in RUNX1 haplodeficiency.J Thromb Haemost2017
28179601Regulation of Ras signaling and function by plasma membrane microdomains.Biosci Trends2017
28500171Platelet microparticles infiltrating solid tumors transfer miRNAs that suppress tumor growth.Blood2017
28676520Transcription Factor RUNX1 Regulates Platelet <i>PCTP</i> (Phosphatidylcholine Transfer Protein): Implications for Cardiovascular Events: Differential Effects of RUNX1 Variants.Circulation2017
26773046Dicer1-mediated miRNA processing shapes the mRNA profile and function of murine platelets.Blood2016
27798864Inhibition of Galectin-1 Sensitizes HRAS-driven Tumor Growth to Rapamycin Treatment.Anticancer Res2016
27239960Regulation of H-Ras-driven MAPK signaling, transformation and tumorigenesis, but not PI3K signaling and tumor progression, by plasma membrane microdomains.Oncogenesis2016
26498519RLIP76 regulates Arf6-dependent cell spreading and migration by linking ARNO with activated R-Ras at recycling endosomes.Biochem Biophys Res Commun2015
24578264Activation of PI3K and R-Ras signaling promotes the extension of sensory axons on inhibitory chondroitin sulfate proteoglycans.Dev Neurobiol2014
25450693The RLIP76 N-terminus binds ARNO to regulate PI 3-kinase, Arf6 and Rac signaling, cell spreading and migration.Biochem Biophys Res Commun2014
25279426Three-dimensional reconstruction of neovasculature in solid tumors and basement membrane matrix using ex vivo X-ray microcomputed tomography.Microcirculation2014
24928198RLIP76 regulates HIF-1 activity, VEGF expression and secretion in tumor cells, and secretome transactivation of endothelial cells.FASEB J2014
24106269RhoG protein regulates glycoprotein VI-Fc receptor γ-chain complex-mediated platelet activation and thrombus formation.J Biol Chem2013
25419163Emerging treatments in lung cancer - targeting the RLIP76 molecular transporter.Lung Cancer (Auckl)2013
22902412RALBP1/RLIP76 depletion in mice suppresses tumor growth by inhibiting tumor neovascularization.Cancer Res2012
22751447Palmitoylation regulates vesicular trafficking of R-Ras to membrane ruffles and effects on ruffling and cell spreading.Small GTPases2012
21736870Protein kinase Cδ mediates the activation of protein kinase D2 in platelets.Biochem Pharmacol2011
20876458Regulation of platelet myosin light chain (MYL9) by RUNX1: implications for thrombocytopenia and platelet dysfunction in RUNX1 haplodeficiency.Blood2010
18329275A small molecule inhibitor of alpha4 integrin-dependent cell migration.Bioorg Med Chem2009
18354782Choose your own path: specificity in Ras GTPase signaling.Mol Biosyst2008
18784251Integrin-mediated protein kinase A activation at the leading edge of migrating cells.Mol Biol Cell2008
18583710Localized alpha4 integrin phosphorylation directs shear stress-induced endothelial cell alignment.Circ Res2008
17439166An experimentally derived database of candidate Ras-interacting proteins.J Proteome Res2007
16966426RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration.J Cell Biol2006
12837751Integrin alpha 4 beta 1-dependent T cell migration requires both phosphorylation and dephosphorylation of the alpha 4 cytoplasmic domain to regulate the reversible binding of paxillin.J Biol Chem2003
12913113Spatial restriction of alpha4 integrin phosphorylation regulates lamellipodial stability and alpha4beta1-dependent cell migration.J Cell Biol2003
14570053Ras GTPases: integrins' friends or foes?Nat Rev Mol Cell Biol2003
11054871Laminins: an overview.Microsc Res Tech2000
10956663Spatial regulation and activity modulation of plasmin by high affinity binding to the G domain of the alpha 3 subunit of laminin-5.J Biol Chem2000
10413670The alpha3 laminin subunit, alpha6beta4 and alpha3beta1 integrin coordinately regulate wound healing in cultured epithelial cells and in the skin.J Cell Sci1999
9699461Structure and assembly of hemidesmosomes.Bioessays1998
9531563Processing of laminin-5 and its functional consequences: role of plasmin and tissue-type plasminogen activator.J Cell Biol1998
  • 1 - 45 of 45

Recommended Authors

Sanford Burnham Prebys Medical Discovery Institute
Career Start Year 2015
Number of shared co-authors 0
Princess Margaret Cancer Centre
Career Start Year 2005
Number of shared co-authors 0
The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
Career Start Year 2004
Number of shared co-authors 0
National Cancer Institute
Career Start Year 2004
Number of shared co-authors 0
Ben-Gurion University of the Negev
Career Start Year 2002
Number of shared co-authors 0
University of Toronto
Career Start Year 2002
Number of shared co-authors 0
Institute of Anatomy, Technische Universitat Dresden School of Medicine
Career Start Year 2001
Number of shared co-authors 0
Jiangsu University Zhenjiang 212013
Career Start Year 1999
Number of shared co-authors 0
The Wistar Institute
Career Start Year 1999
Number of shared co-authors 0
Department of Pharmaceutical Sciences, University of Toronto
Career Start Year 1999
Number of shared co-authors 0
Henan-Macquarie University Joint Centre for Biomedical Innovation, Henan University
Career Start Year 1997
Number of shared co-authors 0
University of Freiburg
Career Start Year 1996
Number of shared co-authors 0
Sungkyunkwan University
Career Start Year 1995
Number of shared co-authors 0
University of Georgia
Career Start Year 1994
Number of shared co-authors 1
University of Copenhagen
Career Start Year 1994
Number of shared co-authors 0
The Institute of Biomedical Sciences, East China Normal University
Career Start Year 1994
Number of shared co-authors 0
Children's Hospital Research Foundation
Career Start Year 1993
Number of shared co-authors 0
West Virginia University Cancer Institute, West Virginia University
Career Start Year 1993
Number of shared co-authors 3
Georgetown University Medical Center
Career Start Year 1991
Number of shared co-authors 0
Vanderbilt University
Career Start Year 1991
Number of shared co-authors 4
Amsterdam University Medical Center
Career Start Year 1989
Number of shared co-authors 0
Instituto do Cancer do Estado de Sao Paulo, Faculdade de Medicina de Sao Paulo
Career Start Year 1989
Number of shared co-authors 0
University of California San Diego
Career Start Year 1988
Number of shared co-authors 2
Rutgers New Jersey Medical School
Career Start Year 1987
Number of shared co-authors 1
Hospital for Sick Children, University of Toronto
Career Start Year 1985
Number of shared co-authors 1
Moores Cancer Center, University of California San Diego
Career Start Year 1984
Number of shared co-authors 0
Broad Institute of MIT and Harvard
Career Start Year 1979
Number of shared co-authors 0
Atrium Health-Levine Cancer Institute
Career Start Year 1979
Number of shared co-authors 0
Knight Cancer Institute, Oregon Health and Sciences University
Career Start Year 1976
Number of shared co-authors 1
Frederick National Laboratory for Cancer Research
Career Start Year 1975
Number of shared co-authors 0

Collaborators

University of California
Co-authored papers 9
University of California
Co-authored papers 3
Co-authored papers 2
University of Virginia
Co-authored papers 2
University of Virginia
Co-authored papers 2
Agenus Inc, American Society for Mass Spectrometry, Hartwick College, Human Proteome Organisation, Large Scale Biology Corp, University of Virginia
Co-authored papers 2
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1
Oregon Health & Science University
Co-authored papers 1
Co-authored papers 1
Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 1
University of Virginia
Co-authored papers 1
Durham VA Healthcare System and Duke University
Co-authored papers 1
University of Virginia
Co-authored papers 1
Co-authored papers 1
Genomics Institute of the Novartis Research Foundation
Co-authored papers 1
Genomics Institute of the Novartis Research Foundation
Co-authored papers 1
and Institute of Engineering in Medicine, University of California
Co-authored papers 1
Center for Genetic Medicine Research, Children's National Research Institute
Co-authored papers 1