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Author Details

Motoyasu Saji
The Ohio State University School of Medicine
1985
130
49
PMIDPaper TitleJournal TitlePublished Year
33110146Akt isoform-specific effects on thyroid cancer development and progression in a murine thyroid cancer model.Sci Rep2020
31146260MAPK- and AKT-activated thyroid cancers are sensitive to group I PAK inhibition.Endocr Relat Cancer2019
31097454Inhibiting BRAF Oncogene-Mediated Radioresistance Effectively Radiosensitizes BRAF<sup>V600E</sup>-Mutant Thyroid Cancer Cells by Constraining DNA Double-Strand Break Repair.Clin Cancer Res2019
30135308Transcriptional targeting of oncogene addiction in medullary thyroid cancer.JCI Insight2018
28011713Germline compound heterozygous poly-glutamine deletion in USF3 may be involved in predisposition to heritable and sporadic epithelial thyroid carcinoma.Hum Mol Genet2017
28164237Cowden syndrome-associated germline succinate dehydrogenase complex subunit D (SDHD) variants cause PTEN-mediated down-regulation of autophagy in thyroid cancer cells.Hum Mol Genet2017
28289712RCAN1-4 is a thyroid cancer growth and metastasis suppressor.JCI Insight2017
29105562Reduced Retinoblastoma Protein Expression Is Associated with Decreased Patient Survival in Medullary Thyroid Cancer.Thyroid2017
28591772Biological Evaluation of a Fluorescent-Imaging Agent for Medullary Thyroid Cancer in an Orthotopic Model.J Clin Endocrinol Metab2017
27542854Genetic variants in thyroid cancer distant metastases.Endocr Relat Cancer2016
26549818Integrin-linked kinase affects signaling pathways and migration in thyroid cancer cells and is a potential therapeutic target.Surgery2016
27504107Bioassays for TSH Receptor Autoantibodies, from FRTL-5 Cells to TSH Receptor-LH/CG Receptor Chimeras: The Contribution of Leonard D. Kohn.Front Endocrinol (Lausanne)2016
27296473Primary Cell Culture Systems for Human Thyroid Studies.Thyroid2016
25722304Breast Cancer-Specific miR Signature Unique to Extracellular Vesicles Includes "microRNA-like" tRNA Fragments.Mol Cancer Res2015
25915504Analysis of exosome release as a cellular response to MAPK pathway inhibition.Langmuir2015
25710562A novel dual AMPK activator/mTOR inhibitor inhibits thyroid cancer cell growth.J Clin Endocrinol Metab2015
24400871Apigenin in combination with Akt inhibition significantly enhances thyrotropin-stimulated radioiodide accumulation in thyroid cells.Thyroid2014
25228413BRAF activates and physically interacts with PAK to regulate cell motility.Endocr Relat Cancer2014
24512487Follicular thyroid cancers demonstrate dual activation of PKA and mTOR as modeled by thyroid-specific deletion of Prkar1a and Pten in mice.J Clin Endocrinol Metab2014
23539728SRGAP1 is a candidate gene for papillary thyroid carcinoma susceptibility.J Clin Endocrinol Metab2013
24238055Development of a calcium-sensing receptor molecular imaging agent.Surgery2013
24030941Localization of CaSR antagonists in CaSR-expressing medullary thyroid cancer.J Clin Endocrinol Metab2013
23709653Development of p21 activated kinase-targeted multikinase inhibitors that inhibit thyroid cancer cell migration.J Clin Endocrinol Metab2013
22136206MicroRNA signature in thyroid fine needle aspiration cytology applied to "atypia of undetermined significance" cases.Thyroid2012
22962422PTEN lipid phosphatase activity and proper subcellular localization are necessary and sufficient for down-regulating AKT phosphorylation in the nucleus in Cowden syndrome.J Clin Endocrinol Metab2012
22109971Sorafenib and Mek inhibition is synergistic in medullary thyroid carcinoma in vitro.Endocr Relat Cancer2012
21751347High-sensitivity TFA-free LC-MS for profiling histones.Proteomics2011
21532616Akt1 deficiency delays tumor progression, vascular invasion, and distant metastasis in a murine model of thyroid cancer.Oncogene2011
21519026Multi-institutional phase II study of selumetinib in patients with metastatic biliary cancers.J Clin Oncol2011
19897009The PI3K-Akt-mTOR pathway in initiation and progression of thyroid tumors.Mol Cell Endocrinol2010
20817787Group I p21-activated kinases regulate thyroid cancer cell migration and are overexpressed and activated in thyroid cancer invasion.Endocr Relat Cancer2010
20455254Human herpes simplex viruses in benign and malignant thyroid tumours.J Pathol2010
20368568Phase II clinical trial of sorafenib in metastatic medullary thyroid cancer.J Clin Oncol2010
18639247Thiazolidinediones downregulate Wnt/beta-catenin signaling via multiple mechanisms in breast cancer cells.J Surg Res2009
19424295Regulation of actin function by protein kinase A-mediated phosphorylation of Limk1.EMBO Rep2009
19255327Phase II trial of sorafenib in metastatic thyroid cancer.J Clin Oncol2009
19306109Regulator of calcineurin 1 modulates cancer cell migration in vitro.Clin Exp Metastasis2009
18314876Troglitazone inhibits cell migration, adhesion, and spreading by modulating cytoskeletal rearrangement in human breast cancer cells.Mol Carcinog2008
16946008AKT in thyroid tumorigenesis and progression.Endocrinology2007
17525119High basal levels of functional toll-like receptor 3 (TLR3) and noncanonical Wnt5a are expressed in papillary thyroid cancer and are coordinately decreased by phenylmethimazole together with cell proliferation and migration.Endocrinology2007
176735712-amino-N-{4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl} acetamide (OSU-03012), a celecoxib derivative, directly targets p21-activated kinase.Mol Pharmacol2007
17296934Gene expression and functional evidence of epithelial-to-mesenchymal transition in papillary thyroid carcinoma invasion.Proc Natl Acad Sci U S A2007
17133106Molecular mechanisms involved in differentiated thyroid cancer invasion and metastasis.Curr Opin Oncol2007
16731791Transcriptional regulation of major histocompatibility complex class I gene by insulin and IGF-I in FRTL-5 thyroid cells.J Endocrinol2006
15713710Genetic classification of benign and malignant thyroid follicular neoplasia based on a three-gene combination.J Clin Endocrinol Metab2005
16286249Dystrophin glycoprotein complex dysfunction: a regulatory link between muscular dystrophy and cancer cachexia.Cancer Cell2005
15896313Akt1 contains a functional leucine-rich nuclear export sequence.Biochem Biophys Res Commun2005
16099856A mouse model of albright hereditary osteodystrophy generated by targeted disruption of exon 1 of the Gnas gene.Endocrinology2005
16002527AKT activation promotes metastasis in a mouse model of follicular thyroid carcinoma.Endocrinology2005
15998767KiSS-1/G protein-coupled receptor 54 metastasis suppressor pathway increases myocyte-enriched calcineurin interacting protein 1 expression and chronically inhibits calcineurin activity.J Clin Endocrinol Metab2005
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Collaborators

Matthew D Ringel
The Ohio State University College of Medicine and Comprehensive Cancer Center
Co-authored papers 63
William H Westra
Icahn School of Medicine at Mount Sinai Hospital.
Co-authored papers 11
Lianbo Yu
The Ohio State University
Co-authored papers 5
Robert C Smallridge
Mayo Clinic School of Medicine, Mayo Clinic
Co-authored papers 5
Albert de la Chapelle
The Ohio State University Comprehensive Cancer Center
Co-authored papers 4
Richard T Kloos
Veracyte Inc.
Co-authored papers 4
Huiling He
The Ohio State University Comprehensive Cancer Center
Co-authored papers 4
Rebecca Nagy
Guardant Health Inc.
Co-authored papers 3
Andrew J Bauer
Children's Hospital of Philadelphia
Co-authored papers 3
Sheue-Yann Cheng
National Cancer Institute, National Institutes of Health
Co-authored papers 3
Wei Li
The Ohio State University
Co-authored papers 3
Sandya Liyanarachchi
The Ohio State University Comprehensive Cancer Center, Comprehensive Cancer Center
Co-authored papers 3
Thomas J Giordano
University of Michigan ann arbor
Co-authored papers 2
Kevin R Coombes
Medical College of Georgia
Co-authored papers 2
Soledad Fernandez
McGill University
Co-authored papers 2
Gilbert J Cote
The University of Texas MD Anderson Cancer Center Houston
Co-authored papers 2
Stephen E Epstein
Co-authored papers 2
Dorota Kula
Maria Sklodowska-Curie Institute - Oncology Center
Co-authored papers 1
Michael C Ostrowski
Hollings Cancer Center, Medical University of South Carolina
Co-authored papers 1
Zbigniew Puch
M. Sklodowska-Curie National Research Institute of Oncology
Co-authored papers 1
Michael M Johns
University of Southern California
Co-authored papers 1
Lisa A Carey
Co-authored papers 1
Yungui Huang
Research Institute at Nationwide Childrens Hospital, University of Iowa
Co-authored papers 1
Ma??gorzata Czetwerty??ska
Maria Sklodowska-Curie Institute - Oncology Centre
Co-authored papers 1
Marek Krawczyk
Medical University of Warsaw
Co-authored papers 1
Keiko Akagi
The University of Texas MD Anderson Cancer Center
Co-authored papers 1
Mary Susan Burnett
Co-authored papers 1
Veronica J Vieland
The Ohio State University
Co-authored papers 1
Agnieszka Bronisz
Mossakowski Medical Research Institute, Polish Academy of Sciences
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