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Author Details

Nicholas Muzyczka
College of Medicine, University of Florida
1972
161
73
PMIDPaper TitleJournal TitlePublished Year
37310260Structural and Biophysical Analysis of Adeno-Associated Virus Serotype 2 Capsid Assembly Variants.J Virol2023
31577935Biodistribution of adeno-associated virus type 2 with mutations in the capsid that contribute to heparan sulfate proteoglycan binding.Virus Res2019
29526688The Lipase Activity of Phospholipase D2 is Responsible for Nigral Neurodegeneration in a Rat Model of Parkinson's Disease.Neuroscience2018
28335618AAV: An Overview of Unanswered Questions.Hum Gene Ther2017
27252527Mutants at the 2-Fold Interface of Adeno-associated Virus Type 2 (AAV2) Structural Proteins Suggest a Role in Viral Transcription for AAV Capsids.J Virol2016
27440903Cryo-electron Microscopy Reconstruction and Stability Studies of the Wild Type and the R432A Variant of Adeno-associated Virus Type 2 Reveal that Capsid Structural Stability Is a Major Factor in Genome Packaging.J Virol2016
25355884Enhanced transgene expression from recombinant single-stranded D-sequence-substituted adeno-associated virus vectors in human cell lines in vitro and in murine hepatocytes in vivo.J Virol2015
26491705Transcytosis in the blood-cerebrospinal fluid barrier of the mouse brain with an engineered receptor/ligand system.Mol Ther Methods Clin Dev2015
26949410The Adeno-Associated Virus Genome Packaging Puzzle.J Mol Genet Med2015
26690810Adeno-Associated Virus Type 2 and Hepatocellular Carcinoma?Hum Gene Ther2015
25943495AAV's Golden Jubilee.Mol Ther2015
25410874Adeno-associated virus serotype 1 (AAV1)- and AAV5-antibody complex structures reveal evolutionary commonalities in parvovirus antigenic reactivity.J Virol2015
24198419Adeno-associated virus capsid proteins may play a role in transcription and second-strand synthesis of recombinant genomes.J Virol2014
26958729AAV-Mediated Gene Therapy for Research and Therapeutic Purposes.Annu Rev Virol2014
24869933Overcoming the cystic fibrosis sputum barrier to leading adeno-associated virus gene therapy vectors.Mol Ther2014
24299301OneBac: platform for scalable and high-titer production of adeno-associated virus serotype 1-12 vectors for gene therapy.Hum Gene Ther2014
23583935Construction, expression, and purification of recombinant αVβ5 integrin.Protein Expr Purif2013
23993979Molecular cloning, overexpression, and an efficient one-step purification of α5β1 integrin.Protein Expr Purif2013
23926356Structural insights into adeno-associated virus serotype 5.J Virol2013
23760240Capsid antibodies to different adeno-associated virus serotypes bind common regions.J Virol2013
23427155Structure and dynamics of adeno-associated virus serotype 1 VP1-unique N-terminal domain and its role in capsid trafficking.J Virol2013
21982980Enhanced expression of Pctk1, Tcf12 and Ccnd1 in hippocampus of rats: Impact on cognitive function, synaptic plasticity and pathology.Neurobiol Learn Mem2012
22915820Evidence for pH-dependent protease activity in the adeno-associated virus capsid.J Virol2012
22496238Structural insight into the unique properties of adeno-associated virus serotype 9.J Virol2012
22434142Glucose regulated protein 78 diminishes α-synuclein neurotoxicity in a rat model of Parkinson disease.Mol Ther2012
21900159Structural studies of adeno-associated virus serotype 8 capsid transitions associated with endosomal trafficking.J Virol2011
20231467Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78.Proc Natl Acad Sci U S A2010
21188139The effect of DNA-dependent protein kinase on adeno-associated virus replication.PLoS One2010
20685142An animal model of PDH deficiency using AAV8-siRNA vector-mediated knockdown of pyruvate dehydrogenase E1α.Mol Genet Metab2010
20797537Myosin IIb regulates actin dynamics during synaptic plasticity and memory formation.Neuron2010
20551914In vivo RNAi-mediated alpha-synuclein silencing induces nigrostriatal degeneration.Mol Ther2010
20664530α-Synuclein expression in rat substantia nigra suppresses phospholipase D2 toxicity and nigral neurodegeneration.Mol Ther2010
20651336Efficacy of recombinant adeno-associated viral vectors serotypes 1, 2, and 5 for the transduction of pancreatic and colon carcinoma cells.Anticancer Res2010
18971280Identification of cellular proteins that interact with the adeno-associated virus rep protein.J Virol2009
19707186Tight Long-term dynamic doxycycline responsive nigrostriatal GDNF using a single rAAV vector.Mol Ther2009
19574648Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 9.Acta Crystallogr Sect F Struct Biol Cryst Commun2009
19121398Heparin binding induces conformational changes in Adeno-associated virus serotype 2.J Struct Biol2009
19142181Striatal readministration of rAAV vectors reveals an immune response against AAV2 capsids that can be circumvented.Mol Ther2009
19277011Nigrostriatal rAAV-mediated GDNF overexpression induces robust weight loss in a rat model of age-related obesity.Mol Ther2009
18057257Complete in vitro reconstitution of adeno-associated virus DNA replication requires the minichromosome maintenance complex proteins.J Virol2008
28189012Adeno-associated Viral (AAV) Serotype 5 Vector Mediated Gene Delivery of Endothelin-converting Enzyme Reduces Aβ Deposits in APP + PS1 Transgenic Mice.Mol Ther2008
18834608Tyrosine-phosphorylation of AAV2 vectors and its consequences on viral intracellular trafficking and transgene expression.Virology2008
18511559Next generation of adeno-associated virus 2 vectors: point mutations in tyrosines lead to high-efficiency transduction at lower doses.Proc Natl Acad Sci U S A2008
18665160Adeno-associated viral (AAV) serotype 5 vector mediated gene delivery of endothelin-converting enzyme reduces Abeta deposits in APP + PS1 transgenic mice.Mol Ther2008
18234529Genome-wide analysis of aging and learning-related genes in the hippocampal dentate gyrus.Neurobiol Learn Mem2008
18178617The phosphorylation state of Ser-129 in human alpha-synuclein determines neurodegeneration in a rat model of Parkinson disease.Proc Natl Acad Sci U S A2008
16829144Changes in transcription within the CA1 field of the hippocampus are associated with age-related spatial learning impairments.Neurobiol Learn Mem2007
18084098Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 7.Acta Crystallogr Sect F Struct Biol Cryst Commun2007
17565350Time course of transgene expression after intrastriatal pseudotyped rAAV2/1, rAAV2/2, rAAV2/5, and rAAV2/8 transduction in the rat.Mol Ther2007
17678648rAAV-mediated nigral human parkin over-expression partially ameliorates motor deficits via enhanced dopamine neurotransmission in a rat model of Parkinson's disease.Exp Neurol2007
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Collaborators

College of Medicine, University of Florida
Co-authored papers 38
University of Florida College of Medicine
Co-authored papers 24
University of Wisconsin-Madison
Co-authored papers 16
Co-authored papers 14
Louisiana State University Health Sciences Center
Co-authored papers 8
Co-authored papers 8
University of Florida College of Medicine
Co-authored papers 5
University of Florida
Co-authored papers 5
University of Florida
Co-authored papers 4
University of Florida
Co-authored papers 3
Co-authored papers 3
College of Medicine, University of Florida
Co-authored papers 3
College of Medicine, University of Florida
Co-authored papers 3
College of Medicine, University of Florida
Co-authored papers 3
Co-authored papers 2
Co-authored papers 2
University of Florida Health System
Co-authored papers 2
University of Florida
Co-authored papers 2
University of Florida College of Medicine.
Co-authored papers 2
American College of Medical Informatics, Department of Veteran Affairs, Harvard University T H Chan School of Public Health, Massachusetts Institute of Technology, The American Society for Clinical Investigation, University of Kentucky, Vanderbilt University Medical Center, Vanderbilt University Medical School
Co-authored papers 1
University of Vermont Larner College of Medicine
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1
McKnight Brain Institute, University of Florida
Co-authored papers 1
University of Kentucky and University of Kentucky Nanobiotechnology Center
Co-authored papers 1
University of Florida
Co-authored papers 1
Malcom Randall Veterans Affairs Medical Center
Co-authored papers 1
Co-authored papers 1
University School of Medicine
Co-authored papers 1