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Author Details

Laurent Taupenot
VA San Diego Healthcare System, University of California at San Diego
1994
70
30
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
23786442Genetic variation at the delta-sarcoglycan (SGCD) locus elevates heritable sympathetic nerve activity in human twin pairs.J Neurochem2013
23674521MicroRNA-22 and promoter motif polymorphisms at the Chga locus in genetic hypertension: functional and therapeutic implications for gene expression and the pathogenesis of hypertension.Hum Mol Genet2013
22393040Human cathepsin V protease participates in production of enkephalin and NPY neuropeptide neurotransmitters.J Biol Chem2012
22916103The protein architecture of human secretory vesicles reveals differential regulation of signaling molecule secretion by protein kinases.PLoS One2012
21558123A common genetic variant in the 3'-UTR of vacuolar H+-ATPase ATP6V0A1 creates a micro-RNA motif to alter chromogranin A processing and hypertension risk.Circ Cardiovasc Genet2011
21597914Catecholamine biosynthesis and secretion: physiological and pharmacological effects of secretin.Cell Tissue Res2011
20061385Pro-hormone secretogranin II regulates dense core secretory granule biogenesis in catecholaminergic cells.J Biol Chem2010
20704348Mass spectrometry-based neuropeptidomics of secretory vesicles from human adrenal medullary pheochromocytoma reveals novel peptide products of prohormone processing.J Proteome Res2010
20571875Human tyrosine hydroxylase natural allelic variation: influence on autonomic function and hypertension.Cell Mol Neurobiol2010
20124442Human tyrosine hydroxylase natural genetic variation: delineation of functional transcriptional control motifs disrupted in the proximal promoter.Circ Cardiovasc Genet2010
20359597Common functional genetic variants in catecholamine storage vesicle protein promoter motifs interact to trigger systemic hypertension.J Am Coll Cardiol2010
20413096Neuroendocrine nicotinic receptor activation increases susceptibility to bacterial infections by suppressing antimicrobial peptide production.Cell Host Microbe2010
20378607Genetic regulation of catecholamine synthesis, storage and secretion in the spontaneously hypertensive rat.Hum Mol Genet2010
20009769Human dopamine beta-hydroxylase (DBH) regulatory polymorphism that influences enzymatic activity, autonomic function, and blood pressure.J Hypertens2010
18973469Determinants for chromogranin A sorting into the regulated secretory pathway are also sufficient to generate granule-like structures in non-endocrine cells.Biochem J2009
20011129Autonomic function in hypertension; role of genetic variation at the catecholamine storage vesicle protein chromogranin B.Circ Cardiovasc Genet2009
19671882Natural variation within the neuronal nicotinic acetylcholine receptor cluster on human chromosome 15q24: influence on heritable autonomic traits in twin pairs.J Pharmacol Exp Ther2009
19372204Cathepsin L colocalizes with chromogranin a in chromaffin vesicles to generate active peptides.Endocrinology2009
19520754Chromogranin A regulates renal function by triggering Weibel-Palade body exocytosis.J Am Soc Nephrol2009
18185531The neuroendocrine peptide catestatin is a cutaneous antimicrobial and induced in the skin after injury.J Invest Dermatol2008
19120120Adrenergic polymorphism and the human stress response.Ann N Y Acad Sci2008
19017515Naturally occurring human genetic variation in the 3'-untranslated region of the secretory protein chromogranin A is associated with autonomic blood pressure regulation and hypertension in a sex-dependent fashion.J Am Coll Cardiol2008
18549247The trans-Golgi proteins SCLIP and SCG10 interact with chromogranin A to regulate neuroendocrine secretion.Biochemistry2008
18591442Heritability and genome-wide linkage in US and australian twins identify novel genomic regions controlling chromogranin a: implications for secretion and blood pressure.Circulation2008
18299326Sorting of the neuroendocrine secretory protein Secretogranin II into the regulated secretory pathway: role of N- and C-terminal alpha-helical domains.J Biol Chem2008
17991725Proteolytic cleavage of human chromogranin a containing naturally occurring catestatin variants: differential processing at catestatin region by plasmin.Endocrinology2008
17241236Nerve growth factor-stimulated neuronal differentiation induces changes in P2 receptor expression and nucleotide-stimulated catecholamine release.J Neurochem2007
18228498Analysis of regulated secretion using PC12 cells.Curr Protoc Cell Biol2007
17540723Cox-2 promotes chromogranin A expression and bioactivity: evidence for a prostaglandin E2-dependent mechanism and the involvement of a proximal cyclic adenosine 5'-monophosphate-responsive element.Endocrinology2007
17546020Primary culture of bovine chromaffin cells.Nat Protoc2007
17698732Tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis: discovery of common human genetic variants governing transcription, autonomic activity, and blood pressure in vivo.Circulation2007
17718510Biogenesis of the secretory granule: chromogranin A coiled-coil structure results in unusual physical properties and suggests a mechanism for granule core condensation.Biochemistry2007
17438153Heredity of endothelin secretion: human twin studies reveal the influence of polymorphism at the chromogranin A locus, a novel determinant of endothelial function.Circulation2007
17242462Granulogenesis in non-neuroendocrine COS-7 cells induced by EGFP-tagged chromogranin A gene transfection: identical and distinct distribution of CgA and EGFP.J Histochem Cytochem2007
16554546Pleiotropic effects of novel trans-acting loci influencing human sympathochromaffin secretion.Physiol Genomics2006
17032650Secretory granule biogenesis in sympathoadrenal cells: identification of a granulogenic determinant in the secretory prohormone chromogranin A.J Biol Chem2006
17026486Catecholamine storage vesicles and the metabolic syndrome: The role of the chromogranin A fragment pancreastatin.Diabetes Obes Metab2006
15542860Role of H+-ATPase-mediated acidification in sorting and release of the regulated secretory protein chromogranin A: evidence for a vesiculogenic function.J Biol Chem2005
15956083Pancreastatin: multiple actions on human intermediary metabolism in vivo, variation in disease, and naturally occurring functional genetic polymorphism.J Clin Endocrinol Metab2005
15138309Genome-wide linkage analysis of chromogranin B expression in the CEPH pedigrees: implications for exocytotic sympathochromaffin secretion in humans.Physiol Genomics2004
15367723Functional allelic heterogeneity and pleiotropy of a repeat polymorphism in tyrosine hydroxylase: prediction of catecholamines and response to stress in twins.Physiol Genomics2004
12795588Primary sequence characterization of catestatin intermediates and peptides defines proteolytic cleavage sites utilized for converting chromogranin a into active catestatin secreted from neuroendocrine chromaffin cells.Biochemistry2003
12646671The chromogranin-secretogranin family.N Engl J Med2003
12432071Identification of a novel sorting determinant for the regulated pathway in the secretory protein chromogranin A.J Cell Sci2002
12438183Chromogranin A-activated microglial cells induce neuronal apoptosis.Ann N Y Acad Sci2002
12438165Fast-breaking results on the PACAP/VIP/secretin peptide family in chromaffin cells.Ann N Y Acad Sci2002
12438162The local chromaffin cell plasminogen/plasmin system and the regulation of catecholamine secretion.Ann N Y Acad Sci2002
12438129Intracellular protein trafficking into catecholamine storage vesicles: novel chimeric photoproteins visualized by deconvolution fluorescence microscopy.Ann N Y Acad Sci2002
11342539Proteolytic cleavage of chromogranin A (CgA) by plasmin. Selective liberation of a specific bioactive CgA fragment that regulates catecholamine release.J Biol Chem2001
10781584Formation of the catecholamine release-inhibitory peptide catestatin from chromogranin A. Determination of proteolytic cleavage sites in hormone storage granules.J Biol Chem2000
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Collaborators

Daniel T O'Connor
Institute for Genomic Medicine, University of California San Diego
Co-authored papers 55
Sushil K Mahata
Co-authored papers 41
Michael G Ziegler
University of California San Diego School of Medicine
Co-authored papers 17
Kuixing Zhang
Co-authored papers 14
Nicholas J Schork
University of California San Diego
Co-authored papers 13
Juan L Rodriguez-Flores
Co-authored papers 10
Vivian Hook
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California
Co-authored papers 8
Rany M Salem
Co-authored papers 8
Gen Wen
Co-authored papers 8
Brinda K Rana
University of California
Co-authored papers 7
Jennifer Wessel
Co-authored papers 5
Bruce A Hamilton
Co-authored papers 4
Ryan S Friese
Co-authored papers 3
Tiffany A Greenwood
University of California San Diego
Co-authored papers 3
Ciel Makena Hightower
Co-authored papers 2
Steven J Bark
University of Houston
Co-authored papers 2
Bamidele O Tayo
Loyola University Medical Center.
Co-authored papers 2
Caroline M Nievergelt
VA San Diego Healthcare System (VASDHS)
Co-authored papers 2
Sajalendu Ghosh
Co-authored papers 2
Pei-An Betty Shih
University of California San Diego
Co-authored papers 1
Pavel A Pevzner
University of California
Co-authored papers 1
John B Whitfield
Co-authored papers 1
Nicholas G Martin
Co-authored papers 1
Paul A Insel
Co-authored papers 1
Bradford W Gibson
The Buck Institute for Research on Aging
Co-authored papers 1
Jill L Wegrzyn
University of Connecticut
Co-authored papers 1
Eleazar Eskin
Co-authored papers 1
Michael Smoot
University of California
Co-authored papers 1
Andrew J Schork
The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH)
Co-authored papers 1
Trey Ideker (CM4AI)
University of California San Diego
Co-authored papers 1
Release 1.2