Skip to Main Content

Author Details

Richard W Farndale
1982
233
68
PMIDPaper TitleJournal TitlePublished Year
36807826Pharmacological Inhibition of Glycoprotein VI- and Integrin α2β1-Induced Thrombus Formation Modulated by the Collagen Type.2023
37894834Local Net Charge State of Collagen Triple Helix Is a Determinant of FKBP22 Binding to Collagen III.2023
37964899Platelet Receptor Glycoprotein VI-Dimer Is Overexpressed in Patients with Atrial Fibrillation at High Risk of Ischemic Stroke.TH Open2023
37150294Platelet glycoprotein VI cluster size is related to thrombus formation and phosphatidylserine exposure in collagen-adherent platelets under arterial shear.2023
36574820What does it take to be a collagen receptor?2023
35306228Tyrosine-sulfated dermatopontin shares multiple binding sites and recognition determinants on triple-helical collagens with proteins implicated in cell adhesion and collagen folding, fibrillogenesis, cross-linking, and degradation.Biochimica et Biophysica Acta - Proteins and Proteomics2022
35494504Factor XIII is a newly identified binding partner for platelet collagen receptor GPVI-dimer-An interaction that may modulate fibrin crosslinking.Research and Practice in Thrombosis and Haemostasis2022
36517525The effects of inhibition and siRNA knockdown of collagen-binding integrins on human umbilical vein endothelial cell migration and tube formation.2022
34348571The voltage-gated K channel Kv1.3 modulates platelet motility and αβ integrin-dependent adhesion to collagen.Platelets2022
35041713Platelet surface receptor glycoprotein VI-dimer is overexpressed in stroke: The Glycoprotein VI in Stroke (GYPSIE) study results.PLoS One2022
35245360Structural insights into collagen binding by platelet receptor glycoprotein VI.Blood2022
34529829THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Catalytic receptors.Br J Pharmacol2021
34032355Dimers of the platelet collagen receptor glycoprotein VI bind specifically to fibrin fibers during clot formation, but not to intact fibrinogen.Journal of Thrombosis and Haemostasis2021
34356607Identification of HSP47 Binding Site on Native Collagen and Its Implications for the Development of HSP47 Inhibitors.Biomolecules2021
33179420Multimerin 1 supports platelet function in vivo and binds to specific GPAGPOGPX motifs in fibrillar collagens that enhance platelet adhesion.Journal of Thrombosis and Haemostasis2021
33385684Modulating hESC-derived cardiomyocyte and endothelial cell function with triple-helical peptides for heart tissue engineering.Biomaterials2021
33267658Nonredundant Roles of Platelet Glycoprotein VI and Integrin αIIbβ3 in Fibrin-Mediated Microthrombus Formation.Arteriosclerosis, Thrombosis, and Vascular Biology2021
34454082Tailoring the biofunctionality of collagen biomaterials via tropoelastin incorporation and EDC-crosslinking.2021
34363821Selectivity of the collagen-binding integrin inhibitors, TC-I-15 and obtustatin.Toxicology and Applied Pharmacology2021
32680988Platelet-primed interactions of coagulation and anticoagulation pathways in flow-dependent thrombus formation.Scientific Reports2020
31907373Chain alignment of collagen I deciphered using computationally designed heterotrimers.Nature Chemical Biology2020
31894636Cleavage by MMP-13 renders VWF unable to bind to collagen but increases its platelet reactivity.Journal of Thrombosis and Haemostasis2020
32110760Activation-induced changes in platelet surface receptor expression and the contribution of the large-platelet subpopulation to activation.Research and Practice in Thrombosis and Haemostasis2020
33149936Collagen scaffolds functionalized with triple-helical peptides support 3D HUVEC culture.Regenerative Biomaterials2020
33293576Mild hyperlipidemia in mice aggravates platelet responsiveness in thrombus formation and exploration of platelet proteome and lipidome.Sci Rep2020
31246483Covalent Capture of a Heterotrimeric Collagen Helix.Organic Letters2019
31586463Impact of UV- and carbodiimide-based crosslinking on the integrin-binding properties of collagen-based materials.2019
31827179Structural studies of the MMP-3 interaction with triple-helical collagen introduce new roles for the enzyme in tissue remodelling.Scientific Reports2019
30586647Cellular response to collagen-elastin composite materials.2019
30658193GPVI surface expression and signalling pathway activation are increased in platelets from obese patients: Elucidating potential anti-atherothrombotic targets in obesity.Atherosclerosis2019
31181592Role of Platelet Glycoprotein VI and Tyrosine Kinase Syk in Thrombus Formation on Collagen-Like Surfaces.International Journal of Molecular Sciences2019
31074960A Comprehensive UHPLC Ion Mobility Quadrupole Time-of-Flight Method for Profiling and Quantification of Eicosanoids, Other Oxylipins, and Fatty Acids.Anal Chem2019
31266822Collagen-binding proteins: insights from the Collagen Toolkits.Essays in Biochemistry2019
31372431Data on hyper-activation of GPVI signalling in obese patients: Towards the identification of novel antiplatelet targets in obesity.Data in Brief2019
29844053Thrombospondin-1 promotes matrix homeostasis by interacting with collagen and lysyl oxidase precursors and collagen cross-linking sites.Science Signaling2018
30218106Proline provides site-specific flexibility for in vivo collagen.Sci Rep2018
30390497Corrigendum to 'Anti-thrombotic efficacy of S007-867: Pre-clinical evaluation in experimental models of thrombosis in vivo and in vitro' [Biochem. Pharmacol. 148 (2018) 288-297].Biochemical Pharmacology2018
30099278Coupling of a specific photoreactive triple-helical peptide to crosslinked collagen films restores binding and activation of DDR2 and VWF.Biomaterials2018
30046741MMP-13 binds to platelet receptors αIIbβ3 and GPVI and impairs aggregation and thrombus formation.Research and Practice in Thrombosis and Haemostasis2018
29309758Anti-thrombotic efficacy of S007-867: Pre-clinical evaluation in experimental models of thrombosis in vivo and in vitro.Biochemical Pharmacology2018
29758270Collagen Gly missense mutations: Effect of residue identity on collagen structure and integrin binding.Journal of Structural Biology2018
29564650Correction to: Evaluation of cell binding to collagen and gelatin: a study of the effect of 2D and 3D architecture and surface chemistry.Journal of Materials Science: Materials in Medicine2018
29210180Platelet collagen receptor Glycoprotein VI-dimer recognizes fibrinogen and fibrin through their D-domains, contributing to platelet adhesion and activation during thrombus formation.Journal of Thrombosis and Haemostasis2018
29512284The chaperone protein HSP47: a platelet collagen binding protein that contributes to thrombosis and hemostasis.J Thromb Haemost2018
29107054Selecting the correct cellular model for assessing of the biological response of collagen-based biomaterials.2018
27915017Fundamental insight into the effect of carbodiimide crosslinking on cellular recognition of collagen-based scaffolds.2017
28536721Differential integrin activity mediated by platelet collagen receptor engagement under flow conditions.Thrombosis and Haemostasis2017
27569273Unique charge-dependent constraint on collagen recognition by integrin α10β1.Matrix Biology2017
28215822Structural and functional analysis of two small leucine-rich repeat proteoglycans, fibromodulin and chondroadherin.Matrix Biology2017
28058806Clustering of glycoprotein VI (GPVI) dimers upon adhesion to collagen as a mechanism to regulate GPVI signaling in platelets.Journal of Thrombosis and Haemostasis2017
  • 1 - 50 of 232

Recommended Authors

Collaborators

University of Cambridge
Co-authored papers 18
Co-authored papers 7
Co-authored papers 6
Co-authored papers 5
Co-authored papers 4
Co-authored papers 4
Co-authored papers 3
Co-authored papers 3
Co-authored papers 3
Co-authored papers 3
Co-authored papers 3
Co-authored papers 3
Co-authored papers 3
Co-authored papers 3
University of Oxford
Co-authored papers 2
Co-authored papers 2
University of Oxford
Co-authored papers 2
Abo Akademi University
Co-authored papers 2
Co-authored papers 2
Co-authored papers 2
Co-authored papers 2
Co-authored papers 2
University of Manchester
Co-authored papers 2
Utrecht University
Co-authored papers 1
UCD Conway Institute, University College Dublin
Co-authored papers 1
VA San Diego Healthcare System (VASDHS)
Co-authored papers 1
Mayo Clinic
Co-authored papers 1
Perelman School of Medicine, University of Pennsylvania
Co-authored papers 1
ICBMS UMR CNRS 5246, University Lyon 1
Co-authored papers 1
Co-authored papers 1