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Author Details

David A Scott
Sanford Burnham Prebys Medical Discovery Institute
1987
79
41
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36626549OGT controls mammalian cell viability by regulating the proteasome/mTOR/ mitochondrial axis.Proc Natl Acad Sci U S A2023
35486677Succinate dehydrogenase/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation.Sci Immunol2022
33945506The deacylase SIRT5 supports melanoma viability by influencing chromatin dynamics.J Clin Invest2021
33653692Macropinocytosis in Cancer-Associated Fibroblasts Is Dependent on CaMKK2/ARHGEF2 Signaling and Functions to Support Tumor and Stromal Cell Fitness.Cancer Discov2021
33704708Analysis of Melanoma Cell Glutamine Metabolism by Stable Isotope Tracing and Gas Chromatography-Mass Spectrometry.Methods Mol Biol2021
33554439MAPK signaling regulates c-MYC for melanoma cell adaptation to asparagine restriction.EMBO Rep2021
33632871Identification and Characterization of IMD-0354 as a Glutamine Carrier Protein Inhibitor in Melanoma.Mol Cancer Ther2021
32499766Dietary Emulsifier Sodium Stearoyl Lactylate Alters Gut Microbiota <i>in vitro</i> and Inhibits Bacterial Butyrate Producers.Front Microbiol2020
320417834-1BBL Regulates the Polarization of Macrophages, and Inhibition of 4-1BBL Signaling Alleviates Imiquimod-Induced Psoriasis.J Immunol2020
31733993Lineage-Restricted Regulation of SCD and Fatty Acid Saturation by MITF Controls Melanoma Phenotypic Plasticity.Mol Cell2020
32729927An acidic residue buried in the dimer interface of isocitrate dehydrogenase 1 (IDH1) helps regulate catalysis and pH sensitivity.Biochem J2020
32123312Targeting metabolic activity in high-risk neuroblastoma through Monocarboxylate Transporter 1 (MCT1) inhibition.Oncogene2020
30670779A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction.Oncogene2019
31740775Translational reprogramming marks adaptation to asparagine restriction in cancer.Nat Cell Biol2019
30827887Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer.Cancer Cell2019
29377793Prediction of enzymatic pathways by integrative pathway mapping.Elife2018
30209241Targeting the Warburg effect via LDHA inhibition engages ATF4 signaling for cancer cell survival.EMBO J2018
30231992Mannose Alters Gut Microbiome, Prevents Diet-Induced Obesity, and Improves Host Metabolism.Cell Rep2018
30249606Inhibitor potency varies widely among tumor-relevant human isocitrate dehydrogenase 1 mutants.Biochem J2018
27270434Metabolic rewiring in melanoma.Oncogene2017
28330869Molecular mechanisms of isocitrate dehydrogenase 1 (IDH1) mutations identified in tumors: The role of size and hydrophobicity at residue 132 on catalytic efficiency.J Biol Chem2017
26971564Registered report: IDH mutation impairs histone demethylation and results in a block to cell differentiation.Elife2016
25749035Glutamate and asparagine cataplerosis underlie glutamine addiction in melanoma.Oncotarget2015
26119730Suppression of PGC-1α Is Critical for Reprogramming Oxidative Metabolism in Renal Cell Carcinoma.Cell Rep2015
26175007Arginylation regulates purine nucleotide biosynthesis by enhancing the activity of phosphoribosyl pyrophosphate synthase.Nat Commun2015
25759021Regulation of glutamine carrier proteins by RNF5 determines breast cancer response to ER stress-inducing chemotherapies.Cancer Cell2015
24407290The metabolic origins of mannose in glycoproteins.J Biol Chem2014
25264250α-synuclein multimers cluster synaptic vesicles and attenuate recycling.Curr Biol2014
24549842Metabolic and bactericidal effects of targeted suppression of NadD and NadE enzymes in mycobacteria.mBio2014
24421398Mannose supplements induce embryonic lethality and blindness in phosphomannose isomerase hypomorphic mice.FASEB J2014
24469453Glucose-dependent de novo lipogenesis in B lymphocytes: a requirement for atp-citrate lyase in lipopolysaccharide-induced differentiation.J Biol Chem2014
23170981'Transient' genetic suppression facilitates generation of hexose transporter null mutants in Leishmania mexicana.Mol Microbiol2013
24068803Fast vesicle transport is required for the slow axonal transport of synapsin.J Neurosci2013
23931995Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway.Neuron2013
22344896The slow axonal transport of alpha-synuclein--mechanistic commonalities amongst diverse cytosolic cargoes.Cytoskeleton (Hoboken)2012
23024808Functional specialization in proline biosynthesis of melanoma.PLoS One2012
22846158Glutamine-fueled mitochondrial metabolism is decoupled from glycolysis in melanoma.Pigment Cell Melanoma Res2012
22925190Tagaturonate-fructuronate epimerase UxaE, a novel enzyme in the hexuronate catabolic network in Thermotoga maritima.Environ Microbiol2012
22836248α-Synuclein inhibits intersynaptic vesicle mobility and maintains recycling-pool homeostasis.J Neurosci2012
22309053Early and selective impairments in axonal transport kinetics of synaptic cargoes induced by soluble amyloid β-protein oligomers.Traffic2012
22289253Predicting outcomes of steady-state ¹³C isotope tracing experiments using Monte Carlo sampling.BMC Syst Biol2012
22360810Reverse TCA cycle flux through isocitrate dehydrogenases 1 and 2 is required for lipogenesis in hypoxic melanoma cells.Pigment Cell Melanoma Res2012
21555071Mechanistic logic underlying the axonal transport of cytosolic proteins.Neuron2011
21998308Comparative metabolic flux profiling of melanoma cell lines: beyond the Warburg effect.J Biol Chem2011
22179592A simple photoactivation and image analysis module for visualizing and analyzing axonal transport with high temporal resolution.Nat Protoc2011
21869600Reversing the Warburg effect through stromal autophagy.Cell Cycle2011
21949237Phosphomannose isomerase inhibitors improve N-glycosylation in selected phosphomannomutase-deficient fibroblasts.J Biol Chem2011
20404152Phosphoproteome dynamics reveal heat-shock protein complexes specific to the Leishmania donovani infectious stage.Proc Natl Acad Sci U S A2010
20709841Deletion of genes encoding cytochrome oxidases and quinol monooxygenase blocks the aerobic-anaerobic shift in Escherichia coli K-12 MG1655.Appl Environ Microbiol2010
20554859A pathologic cascade leading to synaptic dysfunction in alpha-synuclein-induced neurodegeneration.J Neurosci2010
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Collaborators

Andrei L Osterman
Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 18
Ze'ev Ronai
Cancer Center, Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 11
Yongmei Feng
Cancer Center, Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 5
Hudson H Freeze
Co-authored papers 4
Dmitry A Rodionov
Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 3
Irina A Rodionova
University of California at San Diego
Co-authored papers 3
Pedro Aza-Blanc
Sanford-Burnham-Prebys Medical Discovery Institute
Co-authored papers 3
Bobby G Ng
Co-authored papers 2
Michelle Haber
School of Clinical Medicine
Co-authored papers 2
Michael M Meijler
Co-authored papers 2
Richard J Ulevitch
Co-authored papers 2
Eytan Ruppin
National Cancer Institute
Co-authored papers 2
Bernhard O Palsson
University of California San Diego
Co-authored papers 2
Richard B Pearson
Co-authored papers 1
Daniel J Wichelecki
Institute for Genomic Biology, University of Illinois
Co-authored papers 1
Gordon B Mills
Knight Cancer Institute, Oregon Health and Sciences University
Co-authored papers 1
Alexandre R Colas
Co-authored papers 1
Jamie I Fletcher
Co-authored papers 1
Eric Lau
Moffitt Cancer Center
Co-authored papers 1
Kenneth Eng
Caryl and Israel Englander Institute for Precision Medicine
Co-authored papers 1
Hyungsoo Kim
Sungkyunkwan University
Co-authored papers 1
Matthew W Vetting
Albert Einstein College of Medicine
Co-authored papers 1
David L Rimm
Yale University School of Medicine
Co-authored papers 1
Maria T Diaz-Meco
Co-authored papers 1
Colin R Goding
Ludwig Institute for Cancer Research, University of Oxford
Co-authored papers 1
Costas A Lyssiotis
Co-authored papers 1
Ge Yang
College of Chemistry, Sichuan University
Co-authored papers 1
Brian James
Cancer Center, Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 1
Juan F Linares
Co-authored papers 1
Steven A Carr
Broad Institute of MIT and Harvard
Co-authored papers 1
Release 1.2