Author details

Full Name

Zheng Ruan

Affiliation

ORCID

Career Start Year

2013

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36633397	Inhibition of the proton-activated chloride channel PAC by PIP.		2023
35878032	Molecular determinants of pH sensing in the proton-activated chloride channel.	Proc Natl Acad Sci U S A	2022
33503418	Proton-activated chloride channel PAC regulates endosomal acidification and transferrin receptor-mediated endocytosis.	Cell Rep	2021
34285419	Author Correction: Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition.	Nature Structural and Molecular Biology	2021
34168372	Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition.	Nature Structural and Molecular Biology	2021
33149300	Structures and pH-sensing mechanism of the proton-activated chloride channel.	Nature	2020
32101380	Emerging roles of the Î±C-Î²4 loop in protein kinase structure, function, evolution, and disease.	IUBMB Life	2020
32494015	Structures of human pannexin 1 reveal ion pathways and mechanism of gating.	Nature	2020
31339880	LF4/MOK and a CDK-related kinase regulate the number and length of cilia in Tetrahymena.	PLoS Genet	2019
30593491	Two Antagonistic Hippo Signaling Circuits Set the Division Plane at the Medial Position in the Ciliate <i>Tetrahymena</i>.	Genetics	2019
29695735	Integrative annotation and knowledge discovery of kinase post-translational modifications and cancer-associated mutations through federated protein ontologies and resources.	Sci Rep	2018
28911855	Conformationally constrained peptides target the allosteric kinase dimer interface and inhibit EGFR activation.	Bioorg Med Chem	2018
30254053	Substrate binding allosterically relieves autoinhibition of the pseudokinase TRIB1.	Sci Signal	2018
30104348	Altered conformational landscape and dimerization dependency underpins the activation of EGFR by <i>Î±</i>C-<i>Î²</i>4 loop insertion mutations.	Proc Natl Acad Sci U S A	2018
29432127	Coupled regulation by the juxtamembrane and sterile Î± motif (SAM) linker is a hallmark of ephrin tyrosine kinase evolution.	J Biol Chem	2018
27936599	Computational and Experimental Characterization of Patient Derived Mutations Reveal an Unusual Mode of Regulatory Spine Assembly and Drug Sensitivity in EGFR Kinase.	Biochemistry	2017
28413159	The Hippo Pathway Maintains the Equatorial Division Plane in the Ciliate <i>Tetrahymena</i>.	Genetics	2017
27499294	Cerebellar Ataxia and Coenzyme Q Deficiency through Loss of Unorthodox Kinase Activity.	Mol Cell	2016
26925779	Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization.	PLoS Genet	2016
27513745	Correction: Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization.	PLoS Genet	2016
26101090	Mechanistic Insights into R776H Mediated Activation of Epidermal Growth Factor Receptor Kinase.	Biochemistry	2015
25799139	Co-conserved MAPK features couple D-domain docking groove to distal allosteric sites via the C-terminal flanking tail.	PLoS One	2015
23661681	STRAW: Species TRee Analysis Web server.	Nucleic Acids Research	2013