Author details

Full Name

Alfred G Gilman

Affiliation

ORCID

Career Start Year

1963

Papers

213

H Index

120

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
21819235	Silver spoons and other personal reflections.	Annual Review of Pharmacology and Toxicology	2012
19443755	Newsmaker interview. Texas transplant Alfred Gilman guides $3 billion cancer project. Interview by Jocelyn Kaiser.	Science	2009
16446365	Targeted knockdown of G protein subunits selectively prevents receptor-mediated modulation of effectors and reveals complex changes in non-targeted signaling proteins.	Journal of Biological Chemistry	2006
16371464	Gialpha and Gbeta subunits both define selectivity of G protein activation by alpha2-adrenergic receptors.	Proceedings of the National Academy of Sciences of the United States of America	2006
16275912	Resistance to inhibitors of cholinesterase 8A catalyzes release of Galphai-GTP and nuclear mitotic apparatus protein (NuMA) from NuMA/LGN/Galphai-GDP complexes.	Proceedings of the National Academy of Sciences of the United States of America	2005
15488189	Purification and functional analysis of Ric-8A: a guanine nucleotide exchange factor for G-protein alpha subunits.	Methods in Enzymology	2004
12665513	TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors.	Journal of Biological Chemistry	2003
12509430	Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor.	Journal of Biological Chemistry	2003
14623969	Allosteric determinants in guanine nucleotide-binding proteins.	Proceedings of the National Academy of Sciences of the United States of America	2003
11665600	Expression, purification, and assay of cytosolic (catalytic) domains of membrane-bound mammalian adenylyl cyclases.	Methods in Enzymology	2002
11771419	Assay of RGS protein activity in vitro using purified components.	Methods in Enzymology	2002
12080046	Characterization of Saccharomyces cerevisiae acyl-protein thioesterase 1, the enzyme responsible for G protein alpha subunit deacylation in vivo.	Journal of Biological Chemistry	2002
12478301	Overview of the Alliance for Cellular Signaling.	Nature	2002
11665605	Crystallization of complex between soluble domains of adenylyl cyclase and activated Gs alpha.	Methods in Enzymology	2002
14993334	Cross talk: interview with Al Gilman.	Molecular Interventions	2001
12462241	Nobel laureates' letter to President Bush.	Washington Post	2001
10982815	Isolation and characterization of constitutively active mutants of mammalian adenylyl cyclase.	Journal of Biological Chemistry	2000
11089948	Wrong signals about alliance's scope and aim.	Nature	2000
11087399	Molecular basis for P-site inhibition of adenylyl cyclase.	Biochemistry	2000
10521509	Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways.	Journal of Biological Chemistry	1999
9892647	Persistent membrane association of activated and depalmitoylated G protein alpha subunits.	Proceedings of the National Academy of Sciences of the United States of America	1999
10387017	Modulation of the affinity and selectivity of RGS protein interaction with G alpha subunits by a conserved asparagine/serine residue.	Biochemistry	1999
10567430	Selective regulation of Galpha(q/11) by an RGS domain in the G protein-coupled receptor kinase, GRK2.	Journal of Biological Chemistry	1999
10427002	Two-metal-Ion catalysis in adenylyl cyclase.	Science	1999
10480904	A candidate target for G protein action in brain.	Journal of Biological Chemistry	1999
10354616	The interactions of adenylate cyclases with P-site inhibitors.	Trends in Pharmacological Sciences	1999
9748257	Identification of a Gialpha binding site on type V adenylyl cyclase.	Journal of Biological Chemistry	1998
9736641	Dynamic regulation of RGS2 suggests a novel mechanism in G-protein signaling and neuronal plasticity.	J Neurosci	1998
9789084	A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits.	Proc Natl Acad Sci U S A	1998
9651375	GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain.	J Biol Chem	1998
9774453	Sites important for PLCbeta2 activation by the G protein betagamma subunit map to the sides of the beta propeller structure.	Journal of Biological Chemistry	1998
9705312	The A326S mutant of Gialpha1 as an approximation of the receptor-bound state.	Journal of Biological Chemistry	1998
9641916	Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13.	Science	1998
9641915	p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13.	Science	1998
9430654	Mammalian RGS proteins: barbarians at the gate.	J Biol Chem	1998
9632695	Exchange of substrate and inhibitor specificities between adenylyl and guanylyl cyclases.	Journal of Biological Chemistry	1998
9632686	Sites for Galpha binding on the G protein beta subunit overlap with sites for regulation of phospholipase Cbeta and adenylyl cyclase.	Journal of Biological Chemistry	1998
9560227	Sequestration of the G protein beta gamma subunit complex inhibits receptor-mediated endocytosis.	Proceedings of the National Academy of Sciences of the United States of America	1998
9624183	A cytoplasmic acyl-protein thioesterase that removes palmitate from G protein alpha subunits and p21(RAS).	Journal of Biological Chemistry	1998
9201904	Activation of transducin guanosine triphosphatase by two proteins of the RGS family.	Biochemistry	1997
9398661	Organization of G proteins and adenylyl cyclase at the plasma membrane.	Molecular Biology of the Cell	1997
9398294	Structural and biochemical characterization of the GTPgammaS-, GDP.Pi-, and GDP-bound forms of a GTPase-deficient Gly42 --> Val mutant of Gialpha1.	Biochemistry	1997
9395396	Crystal structure of the adenylyl cyclase activator Gsalpha.	Science	1997
9177187	Attenuation of Gi- and Gq-mediated signaling by expression of RGS4 or GAIP in mammalian cells.	Proceedings of the National Academy of Sciences of the United States of America	1997
9177179	Gsalpha contains an unidentified covalent modification that increases its affinity for adenylyl cyclase.	Proceedings of the National Academy of Sciences of the United States of America	1997
9108480	Structure of RGS4 bound to AlF4--activated G(i alpha1): stabilization of the transition state for GTP hydrolysis.	Cell	1997
9012799	RGS4 and GAIP are GTPase-activating proteins for Gq alpha and block activation of phospholipase C beta by gamma-thio-GTP-Gq alpha.	Proc Natl Acad Sci U S A	1997
9417641	Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS.	Science	1997
9346923	The catalytic mechanism of mammalian adenylyl cyclase. Equilibrium binding and kinetic analysis of P-site inhibition.	Journal of Biological Chemistry	1997
9268376	Interactions of forskolin and ATP with the cytosolic domains of mammalian adenylyl cyclase.	Journal of Biological Chemistry	1997