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Author Details

Pasi A J??nne
Dana-Farber Cancer Institute
1986
457
135
PMIDPaper TitleJournal TitlePublished Year
38095056HERTHENA-Lung02: phase III study of patritumab deruxtecan in advanced <i>EGFR</i>-mutated NSCLC after a third-generation EGFR TKI.Future Oncol2024
37806383Real-World Genomic Profile of EGFR Second-Site Mutations and Other Osimertinib Resistance Mechanisms and Clinical Landscape of NSCLC Post-Osimertinib.J Thorac Oncol2024
38042525CNS Efficacy of Osimertinib With or Without Chemotherapy in Epidermal Growth Factor Receptor-Mutated Advanced Non-Small-Cell Lung Cancer.J Clin Oncol2024
34524205Prediction Model for Tumor Volume Nadir in EGFR -mutant NSCLC Patients Treated With EGFR Tyrosine Kinase Inhibitors.J Thorac Imaging2023
37552839MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer.Cancer Discov2023
37694347Trastuzumab Deruxtecan in Patients With <i>HER2</i>-Mutant Metastatic Non-Small-Cell Lung Cancer: Primary Results From the Randomized, Phase II DESTINY-Lung02 Trial.J Clin Oncol2023
37579253Germline <i>EGFR</i> Mutations and Familial Lung Cancer.J Clin Oncol2023
37689979HERTHENA-Lung01, a Phase II Trial of Patritumab Deruxtecan (HER3-DXd) in Epidermal Growth Factor Receptor-Mutated Non-Small-Cell Lung Cancer After Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Therapy and Platinum-Based Chemotherapy.J Clin Oncol2023
37937763Osimertinib with or without Chemotherapy in <i>EGFR</i>-Mutated Advanced NSCLC.N Engl J Med2023
37541244Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer.Cancer Cell2023
37732171Pneumonitis in Patients Receiving Thoracic Radiotherapy and Osimertinib: A Multi-Institutional Study.JTO Clin Res Rep2023
37599043Chasing EGFR Mutations in the Plasma of Patients With Resected NSCLC: Lessons in the ADAURA Era.J Thorac Oncol2023
37024582Genomic and transcriptomic analysis of checkpoint blockade response in advanced non-small cell lung cancer.Nat Genet2023
37121400Molecular markers of metastatic disease in KRAS-mutant lung adenocarcinoma.Ann Oncol2023
37384867Exceptional Response to Bromodomain and Extraterminal Domain Inhibitor Therapy With BMS-986158 in <i>BRD4-NUTM1</i> NUT Carcinoma Harboring a <i>BRD4</i> Splice Site Mutation.JCO Precis Oncol2023
37384411Cotargeting a MYC/eIF4A-survival axis improves the efficacy of KRAS inhibitors in lung cancer.J Clin Invest2023
37212796HERTHENA-Lung01: a phase II study of patritumab deruxtecan (HER3-DXd) in previously treated metastatic <i>EGFR</i>-mutated NSCLC.Future Oncol2023
37279096Early Changes in Circulating Cell-Free KRAS G12C Predict Response to Adagrasib in KRAS Mutant Non-Small Cell Lung Cancer Patients.Clin Cancer Res2023
37097610Clinicopathologic, Genomic, and Immunophenotypic Landscape of ATM Mutations in Non-Small Cell Lung Cancer.Clin Cancer Res2023
37327468Intracranial Efficacy of Adagrasib in Patients From the KRYSTAL-1 Trial With <i>KRAS<sup>G12C</sup></i>-Mutated Non-Small-Cell Lung Cancer Who Have Untreated CNS Metastases.J Clin Oncol2023
37224424Antibody-Drug Conjugates in Lung Cancer: Recent Advances and Implementing Strategies.J Clin Oncol2023
36537204Characterization and management of adverse events observed with mobocertinib (TAK-788) treatment for <i>EGFR</i> exon 20 insertion-positive non-small cell lung cancer.Expert Rev Anticancer Ther2023
36264123Osimertinib + Savolitinib to Overcome Acquired MET-Mediated Resistance in Epidermal Growth Factor Receptor-Mutated, MET-Amplified Non-Small Cell Lung Cancer: TATTON.Cancer Discov2023
34534430Trastuzumab Deruxtecan in <i>HER2</i>-Mutant Non-Small-Cell Lung Cancer.N Engl J Med2022
35708671Association of High Tumor Mutation Burden in Non-Small Cell Lung Cancers With Increased Immune Infiltration and Improved Clinical Outcomes of PD-L1 Blockade Across PD-L1 Expression Levels.JAMA Oncol2022
35678717Activation of Tumor-Cell STING Primes NK-Cell Therapy.Cancer Immunol Res2022
35613620ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1.Mol Cell2022
35507495Trastuzumab Deruxtecan in Non-Small-Cell Lung Cancer.N Engl J Med2022
35507496Trastuzumab Deruxtecan in Non-Small-Cell Lung Cancer. Reply.N Engl J Med2022
35507494Trastuzumab Deruxtecan in Non-Small-Cell Lung Cancer.N Engl J Med2022
35735998Osimertinib plus Selumetinib in EGFR-Mutated Non-Small Cell Lung Cancer After Progression on EGFR-TKIs: A Phase Ib, Open-Label, Multicenter Trial (TATTON Part B).Clin Cancer Res2022
35404393Sunvozertinib, a Selective EGFR Inhibitor for Previously Treated Non-Small Cell Lung Cancer with EGFR Exon 20 Insertion Mutations.Cancer Discov2022
35378251Quinazolinones as allosteric fourth-generation EGFR inhibitors for the treatment of NSCLC.Bioorg Med Chem Lett2022
35534503Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors.Nat Commun2022
35365776Kinase drug discovery 20 years after imatinib.Nat Rev Drug Discov2022
35422503An allosteric inhibitor against the therapy-resistant mutant forms of EGFR in non-small cell lung cancer.Nat Cancer2022
35658005Adagrasib in Non-Small-Cell Lung Cancer Harboring a <i>KRAS<sup>G12C</sup></i> Mutation.N Engl J Med2022
36614913Mobocertinib (TAK-788) in <i>EGFR</i> Exon 20 Insertion+ Metastatic NSCLC: Patient-Reported Outcomes from EXCLAIM Extension Cohort.J Clin Med2022
36455195Response to MEK Inhibitor Therapy in <i>MAP2K1</i> (<i>MEK1</i>) K57N Non-Small-Cell Lung Cancer and Genomic Landscape of <i>MAP2K1</i> Mutations in Non-Small-Cell Lung Cancer.JCO Precis Oncol2022
36150391MPS1 inhibition primes immunogenicity of KRAS-LKB1 mutant lung cancer.Cancer Cell2022
35872166Dissecting the clinicopathologic, genomic, and immunophenotypic correlates of KRAS<sup>G12D</sup>-mutated non-small-cell lung cancer.Ann Oncol2022
36066413MET-Induced CD73 Restrains STING-Mediated Immunogenicity of EGFR-Mutant Lung Cancer.Cancer Res2022
36170509Adagrasib in Non-Small-Cell Lung Cancer. Reply.N Engl J Med2022
36170508Adagrasib in Non-Small-Cell Lung Cancer.N Engl J Med2022
36384036Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19.J Med Chem2022
36153311Genomic and biological study of fusion genes as resistance mechanisms to EGFR inhibitors.Nat Commun2022
36152477Safety of image guided research biopsies in patients with thoracic malignancies.Lung Cancer2022
35181499Osimertinib Plus Durvalumab in Patients With EGFR-Mutated, Advanced NSCLC: A Phase 1b, Open-Label, Multicenter Trial.J Thorac Oncol2022
35149586A Novel HER2-Selective Kinase Inhibitor Is Effective in HER2 Mutant and Amplified Non-Small Cell Lung Cancer.Cancer Res2022
35091439Comparative Analysis and Isoform-Specific Therapeutic Vulnerabilities of KRAS Mutations in Non-Small Cell Lung Cancer.Clin Cancer Res2022
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Collaborators

Harvard Medical School
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Broad Institute
Co-authored papers 32
Massachusetts General Hospital Cancer Center, Harvard Medical School
Co-authored papers 22
Broad Institute of Harvard and MIT
Co-authored papers 19
Memorial Sloan Kettering Cancer Center
Co-authored papers 17
Novartis Institutes for BioMedical Research
Co-authored papers 16
Dana-Farber Cancer Institute
Co-authored papers 16
University Health Network, Princess Margaret Cancer Centre
Co-authored papers 12
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Co-authored papers 11
Dana-Farber Cancer Institute
Co-authored papers 11
University of Texas Southwestern Medical Center
Co-authored papers 10
Massachusetts General Hospital
Co-authored papers 10
Co-authored papers 9
Injury Prevention Research Center, University of North Carolina
Co-authored papers 9
Broad Institute of the Massachusetts Institute of Technology and Harvard
Co-authored papers 9
University Health Network, University of Toronto
Co-authored papers 8
City of Hope Comprehensive Cancer Center
Co-authored papers 8
Co-authored papers 7
Invitae Corporation
Co-authored papers 7
Medical Ethics and Health Policy, University of Pennsylvania
Co-authored papers 7
Co-authored papers 7
Co-authored papers 7
Yale School of Medicine
Co-authored papers 7
Broad Institute of MIT and Harvard, USA Dana-Farber Cancer Institute
Co-authored papers 6
The University of Manchester
Co-authored papers 6
Harvard Stem Cell Institute, Harvard Medical School
Co-authored papers 6
Dana-Farber Cancer Institute
Co-authored papers 6
Dana-Farber Cancer Institute, Harvard Medical School
Co-authored papers 6
Broad Institute of MIT and Harvard
Co-authored papers 6
Dana-Farber Cancer Institute
Co-authored papers 6