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Author Details
Full Name
Larry D Mesner
Affiliation
Center for Public Health Genomics, University of Virginia
ORCID
Career Start Year
1991
Papers
39
H Index
20
Expertise
CM4AI Collaborator
Gloria M Sheynkman (CM4AI)
PMID
Paper Title
Journal Title
Published Year
36993769
Long-read proteogenomics to connect disease-associated sQTLs to the protein isoform effectors of disease.
bioRxiv
2023
37436066
Single-Cell Transcriptomics of Bone Marrow Stromal Cells in Diversity Outbred Mice: A Model for Population-Level scRNA-Seq Studies.
J Bone Miner Res
2023
34710466
Fentanyl-induced acute and conditioned behaviors in two inbred mouse lines: Potential role for Glyoxalase.
Physiol Behav
2022
35695880
Identification of Known and Novel Long Noncoding RNAs Potentially Responsible for the Effects of Bone Mineral Density (BMD) Genomewide Association Study (GWAS) Loci.
J Bone Miner Res
2022
36416764
Transcriptome-wide association study and eQTL colocalization identify potentially causal genes responsible for human bone mineral density GWAS associations.
Elife
2022
36028119
Intramembranous bone regeneration in diversity outbred mice is heritable.
Bone
2022
34099702
Systems genetics in diversity outbred mice inform BMD GWAS and identify determinants of bone strength.
Nat Commun
2021
33792563
Genomic variants within chromosome 14q32.32 regulate bone mass through MARK3 signaling in osteoblasts.
J Clin Invest
2021
32497039
Genetic analysis of osteoblast activity identifies Zbtb40 as a regulator of osteoblast activity and bone mass.
PLoS Genet
2020
31042701
Mouse genome-wide association and systems genetics identifies Lhfp as a regulator of bone mass.
PLoS Genet
2019
27866947
Integrating GWAS and Co-expression Network Data Identifies Bone Mineral Density Genes SPTBN1 and MARK3 and an Osteoblast Functional Module.
Cell Syst
2017
27378017
Network Analysis Implicates Alpha-Synuclein (Snca) in the Regulation of Ovariectomy-Induced Bone Loss.
Sci Rep
2016
25916717
Purification of restriction fragments containing replication intermediates from complex genomes for 2-D gel analysis.
Methods Mol Biol
2015
25916718
Isolation of restriction fragments containing origins of replication from complex genomes.
Methods Mol Biol
2015
24789909
Bicc1 is a genetic determinant of osteoblastogenesis and bone mineral density.
J Clin Invest
2014
24743168
Analysis of the genome and transcriptome of Cryptococcus neoformans var. grubii reveals complex RNA expression and microevolution leading to virulence attenuation.
PLoS Genet
2014
23861383
Bubble-seq analysis of the human genome reveals distinct chromatin-mediated mechanisms for regulating early- and late-firing origins.
Genome Res
2013
21173031
Bubble-chip analysis of human origin distributions demonstrates on a genomic scale significant clustering into zones and significant association with transcription.
Genome Res
2011
22088094
Integrity of chromatin and replicating DNA in nuclei released from fission yeast by semi-automated grinding in liquid nitrogen.
BMC Res Notes
2011
19859818
A winding road to origin discovery.
Chromosome Res
2010
20716953
Preferential association of irreversibly silenced E2F-target genes with pericentromeric heterochromatin in differentiated muscle cells.
Epigenetics
2010
19563104
Purification of restriction fragments containing replication intermediates from complex genomes for 2-D gel analysis.
Methods Mol Biol
2009
19563114
Isolation of restriction fragments containing origins of replication from complex genomes.
Methods Mol Biol
2009
18680119
A revisionist replicon model for higher eukaryotic genomes.
J Cell Biochem
2008
16507369
Isolating apparently pure libraries of replication origins from complex genomes.
Mol Cell
2006
15879555
Specific signals at the 3' end of the DHFR gene define one boundary of the downstream origin of replication.
Genes Dev
2005
16204450
Reproducible doxycycline-inducible transgene expression at specific loci generated by Cre-recombinase mediated cassette exchange.
Nucleic Acids Res
2005
14977920
The promoter of the Chinese hamster ovary dihydrofolate reductase gene regulates the activity of the local origin and helps define its boundaries.
Genes Dev
2004
12529386
The dihydrofolate reductase origin of replication does not contain any nonredundant genetic elements required for origin activity.
Mol Cell Biol
2003
12629222
The matrix attachment region in the Chinese hamster dihydrofolate reductase origin of replication may be required for local chromatid separation.
Proc Natl Acad Sci U S A
2003
10739662
Dispersive initiation of replication in the Chinese hamster rhodopsin locus.
Exp Cell Res
2000
10859355
Amplification of the human dihydrofolate reductase gene via double minutes is initiated by chromosome breaks.
Proc Natl Acad Sci U S A
2000
10757984
Phosphoaminoglycosides inhibit SWI2/SNF2 family DNA-dependent molecular motor domains.
Biochemistry
2000
10713074
A eukaryotic SWI2/SNF2 domain, an exquisite detector of double-stranded to single-stranded DNA transition elements.
J Biol Chem
2000
9885567
Distal sequences, but not ori-beta/OBR-1, are essential for initiation of DNA replication in the Chinese hamster DHFR origin.
Mol Cell
1998
8340396
Laser cross-linking of proteins to nucleic acids. II. Interactions of the bacteriophage T4 DNA replication polymerase accessory proteins complex with DNA.
J Biol Chem
1993
8394114
DNA-dependent adenosinetriphosphatase A: immunoaffinity purification and characterization of immunological reagents.
Biochemistry
1993
1557354
Probing the energetics of oligo(dT).poly(dA) by laser cross-linking.
Proc Natl Acad Sci U S A
1992
1720977
DNA-dependent adenosinetriphosphatase A is the eukaryotic analogue of the bacteriophage T4 gene 44 protein: immunological identity of DNA replication-associated ATPases.
Biochemistry
1991
1 - 39 of 39
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1
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University of California San Diego
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GE Global Research Center
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Erin D Jeffery
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Co-authored papers
1
Stephen S Rich
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Jacobs School of Medicine and Biomedical Sciences, University at Buffalo
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Guizhou Medical University
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University of British Columbia
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1
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