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Author Details

Larry D Mesner
Center for Public Health Genomics, University of Virginia
1991
39
20
Gloria M Sheynkman (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36993769Long-read proteogenomics to connect disease-associated sQTLs to the protein isoform effectors of disease.bioRxiv2023
37436066Single-Cell Transcriptomics of Bone Marrow Stromal Cells in Diversity Outbred Mice: A Model for Population-Level scRNA-Seq Studies.J Bone Miner Res2023
34710466Fentanyl-induced acute and conditioned behaviors in two inbred mouse lines: Potential role for Glyoxalase.Physiol Behav2022
35695880Identification of Known and Novel Long Noncoding RNAs Potentially Responsible for the Effects of Bone Mineral Density (BMD) Genomewide Association Study (GWAS) Loci.J Bone Miner Res2022
36416764Transcriptome-wide association study and eQTL colocalization identify potentially causal genes responsible for human bone mineral density GWAS associations.Elife2022
36028119Intramembranous bone regeneration in diversity outbred mice is heritable.Bone2022
34099702Systems genetics in diversity outbred mice inform BMD GWAS and identify determinants of bone strength.Nat Commun2021
33792563Genomic variants within chromosome 14q32.32 regulate bone mass through MARK3 signaling in osteoblasts.J Clin Invest2021
32497039Genetic analysis of osteoblast activity identifies Zbtb40 as a regulator of osteoblast activity and bone mass.PLoS Genet2020
31042701Mouse genome-wide association and systems genetics identifies Lhfp as a regulator of bone mass.PLoS Genet2019
27866947Integrating GWAS and Co-expression Network Data Identifies Bone Mineral Density Genes SPTBN1 and MARK3 and an Osteoblast Functional Module.Cell Syst2017
27378017Network Analysis Implicates Alpha-Synuclein (Snca) in the Regulation of Ovariectomy-Induced Bone Loss.Sci Rep2016
25916717Purification of restriction fragments containing replication intermediates from complex genomes for 2-D gel analysis.Methods Mol Biol2015
25916718Isolation of restriction fragments containing origins of replication from complex genomes.Methods Mol Biol2015
24789909Bicc1 is a genetic determinant of osteoblastogenesis and bone mineral density.J Clin Invest2014
24743168Analysis of the genome and transcriptome of Cryptococcus neoformans var. grubii reveals complex RNA expression and microevolution leading to virulence attenuation.PLoS Genet2014
23861383Bubble-seq analysis of the human genome reveals distinct chromatin-mediated mechanisms for regulating early- and late-firing origins.Genome Res2013
21173031Bubble-chip analysis of human origin distributions demonstrates on a genomic scale significant clustering into zones and significant association with transcription.Genome Res2011
22088094Integrity of chromatin and replicating DNA in nuclei released from fission yeast by semi-automated grinding in liquid nitrogen.BMC Res Notes2011
19859818A winding road to origin discovery.Chromosome Res2010
20716953Preferential association of irreversibly silenced E2F-target genes with pericentromeric heterochromatin in differentiated muscle cells.Epigenetics2010
19563104Purification of restriction fragments containing replication intermediates from complex genomes for 2-D gel analysis.Methods Mol Biol2009
19563114Isolation of restriction fragments containing origins of replication from complex genomes.Methods Mol Biol2009
18680119A revisionist replicon model for higher eukaryotic genomes.J Cell Biochem2008
16507369Isolating apparently pure libraries of replication origins from complex genomes.Mol Cell2006
15879555Specific signals at the 3' end of the DHFR gene define one boundary of the downstream origin of replication.Genes Dev2005
16204450Reproducible doxycycline-inducible transgene expression at specific loci generated by Cre-recombinase mediated cassette exchange.Nucleic Acids Res2005
14977920The promoter of the Chinese hamster ovary dihydrofolate reductase gene regulates the activity of the local origin and helps define its boundaries.Genes Dev2004
12529386The dihydrofolate reductase origin of replication does not contain any nonredundant genetic elements required for origin activity.Mol Cell Biol2003
12629222The matrix attachment region in the Chinese hamster dihydrofolate reductase origin of replication may be required for local chromatid separation.Proc Natl Acad Sci U S A2003
10739662Dispersive initiation of replication in the Chinese hamster rhodopsin locus.Exp Cell Res2000
10859355Amplification of the human dihydrofolate reductase gene via double minutes is initiated by chromosome breaks.Proc Natl Acad Sci U S A2000
10757984Phosphoaminoglycosides inhibit SWI2/SNF2 family DNA-dependent molecular motor domains.Biochemistry2000
10713074A eukaryotic SWI2/SNF2 domain, an exquisite detector of double-stranded to single-stranded DNA transition elements.J Biol Chem2000
9885567Distal sequences, but not ori-beta/OBR-1, are essential for initiation of DNA replication in the Chinese hamster DHFR origin.Mol Cell1998
8340396Laser cross-linking of proteins to nucleic acids. II. Interactions of the bacteriophage T4 DNA replication polymerase accessory proteins complex with DNA.J Biol Chem1993
8394114DNA-dependent adenosinetriphosphatase A: immunoaffinity purification and characterization of immunological reagents.Biochemistry1993
1557354Probing the energetics of oligo(dT).poly(dA) by laser cross-linking.Proc Natl Acad Sci U S A1992
1720977DNA-dependent adenosinetriphosphatase A is the eukaryotic analogue of the bacteriophage T4 gene 44 protein: immunological identity of DNA replication-associated ATPases.Biochemistry1991
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Collaborators

University of Virginia
Co-authored papers 13
Maine Medical Center Research Institute
Co-authored papers 5
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University of Virginia
Co-authored papers 2
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University of California San Diego
Co-authored papers 1
Canada British Columbia Cancer Research Centre, University of British Columbia
Co-authored papers 1
GE Global Research Center
Co-authored papers 1
Agenus Inc, American Society for Mass Spectrometry, Hartwick College, Human Proteome Organisation, Large Scale Biology Corp, University of Virginia
Co-authored papers 1
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Co-authored papers 1
Jacobs School of Medicine and Biomedical Sciences, University at Buffalo
Co-authored papers 1
Guizhou Medical University
Co-authored papers 1
University of British Columbia
Co-authored papers 1
University of British Columbia
Co-authored papers 1
Co-authored papers 1
University of California-Riverside
Co-authored papers 1
Lundquist Institute at Harbor university of california los angeles Medical Center
Co-authored papers 1
University of Virginia
Co-authored papers 1
Co-authored papers 1
Center for Computational Sciences
Co-authored papers 1
Tufts University
Co-authored papers 1
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RIKEN center for Integrative Medical Sciences, Hiroshima University
Co-authored papers 1
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