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Author Details

Bradly G Wouters
Princess Margaret Cancer Centre, University Health Network and, University of Toronto
1993
196
69
PMIDPaper TitleJournal TitlePublished Year
37979921Exploring the single-cell immune landscape of kidney allograft inflammation using imaging mass cytometry.Am J Transplant2024
36308030An Engineered Paper-Based 3D Coculture Model of Pancreatic Cancer to Study the Impact of Tissue Architecture and Microenvironmental Gradients on Cell Phenotype.Adv Healthc Mater2023
37685927De Novo Design and Development of a Nutrient-Rich Perfusate for Ex Vivo Lung Perfusion with Cell Culture Models.Int J Mol Sci2023
37202533Identification of acquired Notch3 dependency in metastatic Head and Neck Cancer.Commun Biol2023
36810255Evofosfamide for the treatment of human papillomavirus-negative head and neck squamous cell carcinoma.JCI Insight2023
36672367Multicenter International Study of the Consensus Immunoscore for the Prediction of Relapse and Survival in Early-Stage Colon Cancer.Cancers (Basel)2023
36411189L-alanyl-L-glutamine modified perfusate improves human lung cell functions and extend porcine ex vivo lung perfusion.J Heart Lung Transplant2023
36040838Tellurophene-Tagging of Teniposide Facilitates Monitoring by Mass Cytometry.Chembiochem2022
36875717Repurposing Itraconazole and Hydroxychloroquine to Target Lysosomal Homeostasis in Epithelial Ovarian Cancer.Cancer Res Commun2022
36139506Clinical Performance of the Consensus Immunoscore in Colon Cancer in the Asian Population from the Multicenter International SITC Study.Cancers (Basel)2022
33440225Strategic Training in Transdisciplinary Radiation Science for the 21st Century (STARS21): 15-Year Evaluation of an Innovative Research Training Program.Int J Radiat Oncol Biol Phys2021
33651938Mass Spectrometry Imaging Reveals a Gradient of Cancer-like Metabolic States in the Vicinity of Cancer Not Seen in Morphometric Margins from Microscopy.Anal Chem2021
33542074Emergence of Enzalutamide Resistance in Prostate Cancer is Associated with BCL-2 and IKKB Dependencies.Clin Cancer Res2021
33962950NOX4 links metabolic regulation in pancreatic cancer to endoplasmic reticulum redox vulnerability and dependence on PRDX4.Sci Adv2021
32493919Author Correction: Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression.Nat Commun2020
34123126<i>In situ</i> tissue pathology from spatially encoded mass spectrometry classifiers visualized in real time through augmented reality.Chem Sci2020
32897827Multicenter International Society for Immunotherapy of Cancer Study of the Consensus Immunoscore for the Prediction of Survival and Response to Chemotherapy in Stage III Colon Cancer.J Clin Oncol2020
32445698Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma.Cell2020
30686769Integration of Genomic and Transcriptional Features in Pancreatic Cancer Reveals Increased Cell Cycle Progression in Metastases.Cancer Cell2019
31867322Quantitative Visualization of Hypoxia and Proliferation Gradients Within Histological Tissue Sections.Front Bioeng Biotechnol2019
31330989Somatic Alteration Burden Involving Non-Cancer Genes Predicts Prognosis in Early-Stage Non-Small Cell Lung Cancer.Cancers (Basel)2019
30926792Targeting bivalency de-represses Indian Hedgehog and inhibits self-renewal of colorectal cancer-initiating cells.Nat Commun2019
30952818Pantoprazole Affecting Docetaxel Resistance Pathways via Autophagy (PANDORA): Phase II Trial of High Dose Pantoprazole (Autophagy Inhibitor) with Docetaxel in Metastatic Castration-Resistant Prostate Cancer (mCRPC).Oncologist2019
30979813Functional CRISPR and shRNA Screens Identify Involvement of Mitochondrial Electron Transport in the Activation of Evofosfamide.Mol Pharmacol2019
30971489TePhe, a tellurium-containing phenylalanine mimic, allows monitoring of protein synthesis in vivo with mass cytometry.Proc Natl Acad Sci U S A2019
30655535ONECUT2 is a driver of neuroendocrine prostate cancer.Nat Commun2019
29126306The Future of Radiobiology.J Natl Cancer Inst2018
30135316Evofosfamide for the treatment of human papillomavirus-negative head and neck squamous cell carcinoma.JCI Insight2018
29476017Administration of Hypoxia-Activated Prodrug Evofosfamide after Conventional Adjuvant Therapy Enhances Therapeutic Outcome and Targets Cancer-Initiating Cells in Preclinical Models of Colorectal Cancer.Clin Cancer Res2018
29754777International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study.Lancet2018
29453322The mTOR Targets 4E-BP1/2 Restrain Tumor Growth and Promote Hypoxia Tolerance in PTEN-driven Prostate Cancer.Mol Cancer Res2018
27771366Molecular targeting of hypoxia in radiotherapy.Adv Drug Deliv Rev2017
28378028Up-regulation of autophagy is a mechanism of resistance to chemotherapy and can be inhibited by pantoprazole to increase drug sensitivity.Cancer Chemother Pharmacol2017
28726964A β-galactosidase probe for the detection of cellular senescence by mass cytometry.Org Biomol Chem2017
28619042Metabolic targeting of HIF-dependent glycolysis reduces lactate, increases oxygen consumption and enhances response to high-dose single-fraction radiotherapy in hypoxic solid tumors.BMC Cancer2017
28718406Targeting Hypoxia-Inducible Factors for Antiangiogenic Cancer Therapy.Trends Cancer2017
27768182Association of Distinct Mutational Signatures With Correlates of Increased Immune Activity in Pancreatic Ductal Adenocarcinoma.JAMA Oncol2017
27816364In Vivo Imaging Reveals Significant Tumor Vascular Dysfunction and Increased Tumor Hypoxia-Inducible Factor-1α Expression Induced by High Single-Dose Irradiation in a Pancreatic Tumor Model.Int J Radiat Oncol Biol Phys2017
26796735Erratum: A three-dimensional engineered tumour for spatial snapshot analysis of cell metabolism and phenotype in hypoxic gradients.Nat Mater2016
26595121A three-dimensional engineered tumour for spatial snapshot analysis of cell metabolism and phenotype in hypoxic gradients.Nat Mater2016
27822313Quantitative analysis of ChIP-seq data uncovers dynamic and sustained H3K4me3 and H3K27me3 modulation in cancer cells under hypoxia.Epigenetics Chromatin2016
27754980Development of TRACER: tissue roll for analysis of cellular environment and response.Biofabrication2016
27959931MATE2 Expression Is Associated with Cancer Cell Response to Metformin.PLoS One2016
27779123Quantifying hypoxia in human cancers using static PET imaging.Phys Med Biol2016
27800026Hypoxia increases genome-wide bivalent epigenetic marking by specific gain of H3K27me3.Epigenetics Chromatin2016
27709819Isotopologous Organotellurium Probes Reveal Dynamic Hypoxia In Vivo with Cellular Resolution.Angew Chem Int Ed Engl2016
27421140DICER governs characteristics of glioma stem cells and the resulting tumors in xenograft mouse models of glioblastoma.Oncotarget2016
27323329PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia.Nat Cell Biol2016
27278439Drug-induced reactive oxygen species (ROS) rely on cell membrane properties to exert anticancer effects.Sci Rep2016
27070712Hypoxia-activated prodrugs: paths forward in the era of personalised medicine.Br J Cancer2016
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Collaborators

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Princess Margaret Cancer Centre University Health Network
Co-authored papers 51
Philippe Lambin
Maastricht University
Co-authored papers 50
Jeroen J J P van den Beucken
Radboud University Medical Center
Co-authored papers 23
Ludwig Dubois
Maastricht University
Co-authored papers 20
Ravi N Vellanki
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 15
Micha??l G Magagnin
GROW Research Institute, Maastricht University
Co-authored papers 13
Robert G Bristow
University of Toronto
Co-authored papers 12
J. Martin Brown
Stanford University School of Medicine
Co-authored papers 11
Trevor D McKee
University Health Network
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Maud H W Starmans
Ontario Institute for Cancer Research
Co-authored papers 9
Paul C Boutros
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Co-authored papers 9
Renaud Seigneuric
INSERM
Co-authored papers 8
Jan Willem Voncken
Maastricht University
Co-authored papers 7
David W Hedley
Princess Margaret Cancer Centre, University Health Network
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Michael Milosevic
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Richard P Hill
Princess Margaret Cancer Centre
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Adrian L Harris
University of Oxford
Co-authored papers 7
Dirk De Ruysscher
Maastro Clinic
Co-authored papers 7
Natasja G Lieuwes
Maastricht University
Co-authored papers 6
Michelle Chan-Seng-Yue
Princess Margaret Cancer Centre
Co-authored papers 6
Johan Bussink
Radboud University, Nijmegen Medical Centre
Co-authored papers 6
Melania Pintilie
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 5
Paul N Span
Radboud University Medical Center
Co-authored papers 5
Anthony M Joshua
The Kinghorn Cancer Centre, St. Vincent's Hospital Sydney
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Elizabeth Koch
University of Toronto
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Kenneth C Chu
Ontario Institute for Cancer Research
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Syed Haider
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Albert J van der Kogel
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Release 1.2