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Author Details

Anna L Gloyn
2001
176
64
PMIDPaper TitleJournal TitlePublished Year
36543916A genome-wide CRISPR screen identifies CALCOCO2 as a regulator of beta cell function influencing type 2 diabetes risk.Nat Genet2023
36216889The contribution of functional HNF1A variants and polygenic susceptibility to risk of type 2 diabetes in ancestrally diverse populations.Diabetologia2023
37664823Management of Neonatal Diabetes due to a Mutation with Automated Insulin Delivery System and Remote Patient Monitoring.2023
37745551Multiplexed CRISPR gene editing in primary human islet cells with Cas9 ribonucleoprotein.2023
37736013Inferring causal genes at type 2 diabetes GWAS loci through chromosome interactions in islet cells.2023
37808701Rare variant association analysis in 51,256 type 2 diabetes cases and 370,487 controls informs the spectrum of pathogenicity of monogenic diabetes genes.medRxiv2023
37905040Electrophysiological characterisation of iPSC-derived human β-like cells and an disease model.2023
37987887Heterogeneity of increased biological age in type 2 diabetes correlates with differential tissue DNA methylation, biological variables, and pharmacological treatments.2023
37794253Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine.Nat Med2023
37794142The use of precision diagnostics for monogenic diabetes: a systematic review and expert opinion.Commun Med (Lond)2023
37777536PAX4 loss of function increases diabetes risk by altering human pancreatic endocrine cell development.2023
37689631Safe use of the ketogenic diet in an infant with microcephaly, epilepsy, and diabetes syndrome: a case report.2023
37090505Type 2 Diabetes risk alleles in Peptidyl-glycine Alpha-amidating Monooxygenase influence GLP-1 levels and response to GLP-1 Receptor Agonists.2023
37080883Small but mighty: microexons in glucose homeostasis.2023
37394429An Atlas of Variant Effects to understand the genome at nucleotide resolution.Genome Biol2023
37131594A Systematic Review of the use of Precision Diagnostics in Monogenic Diabetes.medRxiv2023
35551307Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation.Nat Genet2022
35953581Every islet matters: improving the impact of human islet research.Nature Metabolism2022
34644572TIGER: The gene expression regulatory variation landscape of human pancreatic islets.Cell Rep2021
33529164Monogenic diabetes: a gateway to precision medicine in diabetes.J Clin Invest2021
34196608100 YEARS OF INSULIN: A brief history of diabetes genetics: insights for pancreatic beta-cell development and function.Journal of Endocrinology2021
34325839Genetics of Type 2 Diabetes: Opportunities for Precision Medicine: JACC Focus Seminar.Journal of the American College of Cardiology2021
34183851There is more than one way to reach type 2 diabetes.Nature Metabolism2021
32999275Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D.Nat Commun2020
32304665Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma.Cell2020
32005524Editorial Overview: "Islet Biology in Type 2 Diabetes".Journal of Molecular Biology2020
32001615Homozygous Hypomorphic <i>HNF1A</i> Alleles Are a Novel Cause of Young-Onset Diabetes and Result in Sulfonylurea-Sensitive Diabetes.Diabetes Care2020
31945378From Genetic Association to Molecular Mechanisms for Islet-cell Dysfunction in Type 2 Diabetes.Journal of Molecular Biology2020
31883919Analysis of Differentiation Protocols Defines a Common Pancreatic Progenitor Molecular Signature and Guides Refinement of Endocrine Differentiation.Stem Cell Reports2020
32099086Insights into pancreatic islet cell dysfunction from type 2 diabetes mellitus genetics.Nature Reviews Endocrinology2020
31985400Deep learning models predict regulatory variants in pancreatic islets and refine type 2 diabetes association signals.eLife2020
33186544A Multi-omic Integrative Scheme Characterizes Tissues of Action at Loci Associated with Type 2 Diabetes.Am J Hum Genet2020
32910913Unsupervised Clustering of Missense Variants in HNF1A Using Multidimensional Functional Data Aids Clinical Interpretation.Am J Hum Genet2020
32958621Response to Comment on Misra et al. Homozygous Hypomorphic <i>HNF1A</i> Alleles Are a Novel Cause of Young-Onset Diabetes and Result in Sulfonylurea-Sensitive Diabetes. Diabetes Care 2020;43:909-912.Diabetes Care2020
31197398Fostering improved human islet research: a European perspective.Diabetologia2019
31676859Loss of ZnT8 function protects against diabetes by enhanced insulin secretion.Nature Genetics2019
31604268Translational genomics and precision medicine: Moving from the lab to the clinic.Science2019
32694741Exocrine or endocrine? A circulating pancreatic elastase that regulates glucose homeostasis.Nature Metabolism2019
30455330Plasma Fucosylated Glycans and C-Reactive Protein as Biomarkers of HNF1A-MODY in Young Adult-Onset Nonautoimmune Diabetes.Diabetes Care2019
30914061Developing a network view of type 2 diabetes risk pathways through integration of genetic, genomic and functional data.Genome Medicine2019
29632379Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition.Nat Genet2018
30451893Electrophysiological properties of human beta-cell lines EndoC-βH1 and -βH2 conform with human beta-cells.Scientific Reports2018
30297969Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps.Nat Genet2018
30054598Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic β-cells.Nature Genetics2018
30087441Author Correction: Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition.Nat Genet2018
30042179Understanding human fetal pancreas development using subpopulation sorting, RNA sequencing and single-cell profiling.Development (Cambridge)2018
29675560Patterns of differential gene expression in a cellular model of human islet development, and relationship to type 2 diabetes predisposition.Diabetologia2018
29141982A Partial Loss-of-Function Variant in <i>AKT2</i> Is Associated With Reduced Insulin-Mediated Glucose Uptake in Multiple Insulin-Sensitive Tissues: A Genotype-Based Callback Positron Emission Tomography Study.Diabetes2018
29666556Maturity onset diabetes of the young due to variants in Croatia.Biochemia Medica2018
29699867Precision medicine in the management of type 2 diabetes.Lancet Diabetes and Endocrinology,The2018
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