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Author Details

Peter Walter
University of California san francisco
1977
316
115
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37945896A helical fulcrum in eIF2B coordinates allosteric regulation of stress signaling.Nat Chem Biol2024
37857833A Legionella toxin exhibits tRNA mimicry and glycosyl transferase activity to target the translation machinery and trigger a ribotoxic stress response.Nat Cell Biol2023
35191199Intercepting IRE1 kinase-FMRP signaling prevents atherosclerosis progression.EMBO Mol Med2022
35550246Conserved structural elements specialize ATAD1 as a membrane protein extraction machine.Elife2022
35730415Endoplasmic reticulum stress activates human IRE1α through reversible assembly of inactive dimers into small oligomers.Elife2022
35416150A point mutation in the nucleotide exchange factor eIF2B constitutively activates the integrated stress response by allosteric modulation.Elife2022
35513725Systematic characterization of gene function in the photosynthetic alga Chlamydomonas reinhardtii.Nat Genet2022
36227915Aberrant cortical spine dynamics after concussive injury are reversed by integrated stress response inhibition.Proc Natl Acad Sci U S A2022
34516914Cristae-dependent quality control of the mitochondrial genome.Sci Adv2021
33600553Correction: Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response.J Cell Biol2021
33904404Protomer alignment modulates specificity of RNA substrate recognition by Ire1.Elife2021
33688831eIF2B conformation and assembly state regulate the integrated stress response.Elife2021
34911951Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α.Nat Commun2021
34876554Viral evasion of the integrated stress response through antagonism of eIF2-P binding to eIF2B.Nat Commun2021
34591618The stress-sensing domain of activated IRE1α forms helical filaments in narrow ER membrane tubes.Science2021
34726286BAX inhibitor-1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response.EMBO J2021
31550413Structural insights into ISRIB, a memory-enhancing inhibitor of the integrated stress response.FEBS J2020
31999255Structure of the AAA protein Msp1 reveals mechanism of mislocalized membrane protein extraction.Elife2020
31904339Misfolded proteins bind and activate death receptor 5 to trigger apoptosis during unresolved endoplasmic reticulum stress.Elife2020
31871156Quantitative microscopy reveals dynamics and fate of clustered IRE1α.Proc Natl Acad Sci U S A2020
31884883Integrated Stress Response Inhibitor Reverses Sex-Dependent Behavioral and Cell-Specific Deficits after Mild Repetitive Head Trauma.J Neurotrauma2020
33258451Small molecule cognitive enhancer reverses age-related memory decline in mice.Elife2020
33273113Coexpressed subunits of dual genetic origin define a conserved supercomplex mediating essential protein import into chloroplasts.Proc Natl Acad Sci U S A2020
33154106An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike.Science2020
32690955Inhibition of the integrated stress response by viral proteins that block p-eIF2-eIF2B association.Nat Microbiol2020
32886535Msp1/ATAD1 in Protein Quality Control and Regulation of Synaptic Activities.Annu Rev Cell Dev Biol2020
32817938An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation.bioRxiv2020
32409639Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response.Nat Commun2020
32327570The integrated stress response: From mechanism to disease.Science2020
32270040Ribosome-associated vesicles: A dynamic subcompartment of the endoplasmic reticulum in secretory cells.Sci Adv2020
32265225IRE1α Disruption in Triple-Negative Breast Cancer Cooperates with Antiangiogenic Therapy by Reversing ER Stress Adaptation and Remodeling the Tumor Microenvironment.Cancer Res2020
31532710Mrx6 regulates mitochondrial DNA copy number in <i>Saccharomyces cerevisiae</i> by engaging the evolutionarily conserved Lon protease Pim1.Mol Biol Cell2020
30670466The Unfolded Protein Response: Detecting and Responding to Fluctuations in the Protein-Folding Capacity of the Endoplasmic Reticulum.Cold Spring Harb Perspect Biol2019
33654817<i>In vitro</i> RNA Cleavage Assays to Characterize IRE1-dependent RNA Decay.Bio Protoc2019
31727829Activation of the ISR mediates the behavioral and neurophysiological abnormalities in Down syndrome.Science2019
31612858The Mars1 kinase confers photoprotection through signaling in the chloroplast unfolded protein response.Elife2019
31237564tRNA ligase structure reveals kinetic competition between non-conventional mRNA splicing and mRNA decay.Elife2019
31371506Disruption of IRE1α through its kinase domain attenuates multiple myeloma.Proc Natl Acad Sci U S A2019
31399538Withdrawal: Lipase maturation factor LMF1, membrane topology and interaction with lipase proteins in the endoplasmic reticulum.J Biol Chem2019
31539315From symbiont to parasite: the evolution of for-profit science publishing.Mol Biol Cell2019
31149896Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether.Elife2019
31048491eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response.Science2019
30674674Small molecule ISRIB suppresses the integrated stress response within a defined window of activation.Proc Natl Acad Sci U S A2019
29599213Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule.Science2018
29991746Confirming a critical role for death receptor 5 and caspase-8 in apoptosis induction by endoplasmic reticulum stress.Cell Death Differ2018
29985129Engineering ER-stress dependent non-conventional mRNA splicing.Elife2018
29649448Retraction Notice to: The Unfolded Protein Response Element IRE1α Senses Bacterial Proteins Invading the ER to Activate RIG-I and Innate Immune Signaling.Cell Host Microbe2018
29700255Günter Blobel (1936-2018).Science2018
29720449Development of a stress response therapy targeting aggressive prostate cancer.Sci Transl Med2018
28794014Iron affects Ire1 clustering propensity and the amplitude of endoplasmic reticulum stress signaling.J Cell Sci2017
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Collaborators

G??nter Blobel
Howard Hughes Medical Institute, The Rockefeller University
Co-authored papers 24
Robert M Stroud
University of California San Francisco
Co-authored papers 18
Carmela Sidrauski
Calico Life Sciences LLC
Co-authored papers 15
Jonathan S Weissman
Whitehead Institute for Biomedical Research
Co-authored papers 12
Pablo S Aguilar
Instituto de Fisiologia
Co-authored papers 8
Lan Wang
University of California san francisco
Co-authored papers 8
Aditya A Anand
University of California san francisco
Co-authored papers 8
David Pincus
Co-authored papers 8
Tobias C Walther
Harvard T. H. Chan School of Public Health
Co-authored papers 8
Morgane Boone
Center for Medical Biotechnology
Co-authored papers 8
Mark A Poritz
BioFire Diagnostics Inc.
Co-authored papers 7
Kevan M Shokat
University of California San Francisco
Co-authored papers 6
Vladislav Belyy
University of California at San Francisco
Co-authored papers 6
Silke Nock
Howard Hughes Medical Institute, University of California at San Francisco
Co-authored papers 5
Adam R Renslo
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 5
Jeffery S Cox
University of California berkeley
Co-authored papers 5
David W Andrews
Sunnybrook Research Institute, University of Toronto
Co-authored papers 5
Jordan C Tsai
University of California san francisco
Co-authored papers 5
Michael Schoof
Howard Hughes Medical Institute, University of California at San Francisco
Co-authored papers 5
Adam Frost
University of California San Francisco
Co-authored papers 5
David Ron
Cambridge Institute for Medical Research, University of Cambridge
Co-authored papers 5
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 5
Maya Schuldiner
The Weizmann Institute of Science
Co-authored papers 4
Florian Fr??hlich
Osnabruck University Department of Biology/Chemistry Bioanalytical Chemistry section
Co-authored papers 4
Priyadarshini Jaishankar
Department of Pharmaceutical Chemistry, University of California san francisco
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Henry C Nguyen
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