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Author Details

Amy S Espeseth
Merck & Co., Inc.
1989
66
34
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37777449Evaluation of a stabilized RSV pre-fusion F mRNA vaccine: Preclinical studies and Phase 1 clinical testing in healthy adults.Vaccine2023
34879230Upper and lower respiratory tract correlates of protection against respiratory syncytial virus following vaccination of nonhuman primates.Cell Host Microbe2022
35680500Characterization of humoral and cell-mediated immunity induced by mRNA vaccines expressing influenza hemagglutinin stem and nucleoprotein in mice and nonhuman primates.Vaccine2022
35915046Preclinical immunogenicity and efficacy of a candidate COVID-19 vaccine based on a vesicular stomatitis virus-SARS-CoV-2 chimera.EBioMedicine2022
33121346A phase 1, randomized, placebo-controlled study to evaluate the safety and immunogenicity of an mRNA-based RSV prefusion F protein vaccine in healthy younger and older adults.Hum Vaccin Immunother2021
33766889Generation of SARS-CoV-2 reporter replicon for high-throughput antiviral screening and testing.Proc Natl Acad Sci U S A2021
34852943Novel adjuvants enhance immune responses elicited by a replication-defective human cytomegalovirus vaccine in nonhuman primates.Vaccine2021
34775220Forward and reverse translational approaches to predict efficacy of neutralizing respiratory syncytial virus (RSV) antibody prophylaxis.EBioMedicine2021
33361306Potent Bispecific Neutralizing Antibody Targeting Glycoprotein B and the gH/gL/pUL128/130/131 Complex of Human Cytomegalovirus.Antimicrob Agents Chemother2021
32128257Modified mRNA/lipid nanoparticle-based vaccines expressing respiratory syncytial virus F protein variants are immunogenic and protective in rodent models of RSV infection.NPJ Vaccines2020
30381239Development and application of a higher throughput RSV plaque assay by immunofluorescent imaging.J Virol Methods2019
31356650Identification of adipocyte plasma membrane-associated protein as a novel modulator of human cytomegalovirus infection.PLoS Pathog2019
31511385A Replication-Defective Human Cytomegalovirus Vaccine Elicits Humoral Immune Responses Analogous to Those with Natural Infection.J Virol2019
31153687Antibody responses to crucial functional epitopes as a novel approach to assess immunogenicity of vaccine adjuvants.Vaccine2019
29599087A novel method for strict intranasal delivery of non-replicating RSV vaccines in cotton rats and non-human primates.Vaccine2018
30144190Spectroscopic analysis of chlamydial major outer membrane protein in support of structure elucidation.Protein Sci2018
30340881Design and characterization of a fusion glycoprotein vaccine for Respiratory Syncytial Virus with improved stability.Vaccine2018
28747497Genetic Stability of Parainfluenza Virus 5-Vectored Human Respiratory Syncytial Virus Vaccine Candidates after <i>In Vitro</i> and <i>In Vivo</i> Passage.J Virol2017
28298602A Single-Dose Recombinant Parainfluenza Virus 5-Vectored Vaccine Expressing Respiratory Syncytial Virus (RSV) F or G Protein Protected Cotton Rats and African Green Monkeys from RSV Challenge.J Virol2017
29121080Respiratory syncytial virus elicits enriched CD8+ T lymphocyte responses in lung compared with blood in African green monkeys.PLoS One2017
29263890Complement enhances in vitro neutralizing potency of antibodies to human cytomegalovirus glycoprotein B (gB) and immune sera induced by gB/MF59 vaccination.NPJ Vaccines2017
29088734Active evolution of memory B-cells specific to viral gH/gL/pUL128/130/131 pentameric complex in healthy subjects with silent human cytomegalovirus infection.Oncotarget2017
27249069Functional analysis of human cytomegalovirus UL/b' region using SCID-hu mouse model.J Med Virol2016
27797961A replication-defective human cytomegalovirus vaccine for prevention of congenital infection.Sci Transl Med2016
27764150Stability Characterization of a Vaccine Antigen Based on the Respiratory Syncytial Virus Fusion Glycoprotein.PLoS One2016
27464881Recombinant expression of Chlamydia trachomatis major outer membrane protein in E. Coli outer membrane as a substrate for vaccine research.BMC Microbiol2016
25136952Selective HDAC inhibition for the disruption of latent HIV-1 infection.PLoS One2014
24297878Pentameric complex of viral glycoprotein H is the primary target for potent neutralization by a human cytomegalovirus vaccine.Proc Natl Acad Sci U S A2013
21448273siRNA screening of a targeted library of DNA repair factors in HIV infection reveals a role for base excision repair in HIV integration.PLoS One2011
21448280The base excision repair pathway is required for efficient lentivirus integration.PLoS One2011
20176482SAR of tertiary carbinamine derived BACE1 inhibitors: role of aspartate ligand amine pKa in enzyme inhibition.Bioorg Med Chem Lett2010
19036583Identification of a small molecule beta-secretase inhibitor that binds without catalytic aspartate engagement.Bioorg Med Chem Lett2009
19590405Expression of latent human immunodeficiency type 1 is induced by novel and selective histone deacetylase inhibitors.AIDS2009
19409780Discovery of aminoheterocycles as a novel beta-secretase inhibitor class: pH dependence on binding activity part 1.Bioorg Med Chem Lett2009
19478882Host cell factors in HIV replication: meta-analysis of genome-wide studies.PLoS Pathog2009
19239360Expression of latent HIV induced by the potent HDAC inhibitor suberoylanilide hydroxamic acid.AIDS Res Hum Retroviruses2009
19279091A limited group of class I histone deacetylases acts to repress human immunodeficiency virus type 1 expression.J Virol2009
18854490First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates.J Pharmacol Exp Ther2009
18628291Hit selection with false discovery rate control in genome-scale RNAi screens.Nucleic Acids Res2008
18811140Discovery and X-ray crystallographic analysis of a spiropiperidine iminohydantoin inhibitor of beta-secretase.J Med Chem2008
18976975Genome-scale RNAi screen for host factors required for HIV replication.Cell Host Microbe2008
18480473Integrating experimental and analytic approaches to improve data quality in genome-wide RNAi screens.J Biomol Screen2008
17458843Design and synthesis of 2,3,5-substituted imidazolidin-4-one inhibitors of BACE-1.ChemMedChem2007
17583334Discovery of isonicotinamide derived beta-secretase inhibitors: in vivo reduction of beta-amyloid.J Med Chem2007
17670825c-Myc and Sp1 contribute to proviral latency by recruiting histone deacetylase 1 to the human immunodeficiency virus type 1 promoter.J Virol2007
17257835Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind beta-secretase in a N-terminal 10s-loop down conformation.Bioorg Med Chem Lett2007
17438372High-throughput screening by RNA interference: control of two distinct types of variance.Cell Cycle2007
17435171The use of strictly standardized mean difference for hit selection in primary RNA interference high-throughput screening experiments.J Biomol Screen2007
16690314BACE-1 inhibition by a series of psi[CH2NH] reduced amide isosteres.Bioorg Med Chem Lett2006
17098871LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease.Proc Natl Acad Sci U S A2006
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Collaborators

Daria J Hazuda
Merck & Co. Inc.
Co-authored papers 25
Marc Ferrer
National Institutes of Health, National Center for Advancing Translational Sciences
Co-authored papers 8
Ningyan Zhang
Stem Cell Translational Research Center of Tongji Hospital, Tongji University
Co-authored papers 6
Kalpit A Vora
Co-authored papers 6
Zhiqiang An
Zhengzhou University
Co-authored papers 6
Honglin Zhou
Merck & Co., Inc.
Co-authored papers 3
Sheri A Dubey
Co-authored papers 2
Hang Su
Co-authored papers 2
Alan D Frankel
University of California san francisco
Co-authored papers 1
Douglas A Lauffenburger
Massachusetts Institute of Technology
Co-authored papers 1
Sourav Bandyopadhyay
University of California San Francisco
Co-authored papers 1
Jane Fontenot
Co-authored papers 1
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 1
James E Bruce
Co-authored papers 1
Nickita Mehta
Co-authored papers 1
Nirav Malani
University of Pennsylvania Perelman School of Medicine
Co-authored papers 1
Lauren M Hook
Perelman School of Medicine, University of Pennsylvania
Co-authored papers 1
Iv??n D'Orso
University of Texas Southwestern Medical Center
Co-authored papers 1
Robert W Sobol
University of South Alabama
Co-authored papers 1
Jishnu Das
Co-authored papers 1
Viswanath Devanarayan
Clinical Evidence Generation, Eisai Inc.
Co-authored papers 1
Frederic D Bushman
Perelman School of Medicine, University of Pennsylvania
Co-authored papers 1
Stephen P Goff
Columbia University
Co-authored papers 1
Galit Alter
Co-authored papers 1
Jason D Fernandes
University of California san francisco
Co-authored papers 1
John A T Young
Roche Pharma
Co-authored papers 1
Tracy L Diamond
Merck & Co. Inc.
Co-authored papers 1
Trey Ideker (CM4AI)
University of California San Diego
Co-authored papers 1
Nikolai Petrovsky
Co-authored papers 1
Gerard Cagney
Conway Institute of Biomedical and Biomolecular Sciences, University College Dublin
Co-authored papers 1
Release 1.2