Author details

Full Name

Themistocles L Assimes

Affiliation

ORCID

Career Start Year

1998

Papers

231

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37503069	Systems Age: A single blood methylation test to quantify aging heterogeneity across 11 physiological systems.		2023
36409989	Genetic evidence for causal relationships between age at natural menopause and the risk of ageing-associated adverse health outcomes.	International Journal of Epidemiology	2023
38014560	Plasma Protein Profiling of Incident Cardiovascular Diseases: A Multisample Evaluation.	Circ Genom Precis Med	2023
37658231	Assessing efficiency of fine-mapping obesity-associated variants through leveraging ancestry architecture and functional annotation using PAGE and UKBB cohorts.	Hum Genet	2023
37961706	CXCL12 regulates coronary artery dominance in diverse populations and links development to disease.	medRxiv	2023
37961335	<i>CYP2C19</i> Polymorphisms and Clinical Outcomes Following Percutaneous Coronary Intervention (PCI) in the Million Veterans Program.	medRxiv	2023
37550624	Proteomic analysis of 92 circulating proteins and their effects in cardiometabolic diseases.	Clin Proteomics	2023
38049854	Mendelian randomization analyses suggest a causal role for circulating GIP and IL-1RA levels in homeostatic model assessment-derived measures of Î²-cell function and insulin sensitivity in Africans without type 2 diabetes.	Genome Med	2023
37770635	Multi-ancestry genome-wide study identifies effector genes and druggable pathways for coronary artery calcification.	Nat Genet	2023
37414900	A multi-ancestry polygenic risk score improves risk prediction for coronary artery disease.	Nat Med	2023
37409455	Contemporary Polygenic Scores of Low-Density Lipoprotein Cholesterol and Coronary Artery Disease Predict Coronary Atherosclerosis in Adolescents and Young Adults.	Circ Genom Precis Med	2023
36649705	Epigenome-wide meta-analysis of BMI in nine cohorts: Examining the utility of epigenetically predicted BMI.	Am J Hum Genet	2023
37205563	Mendelian randomization analyses clarify the effects of height on cardiovascular diseases.	medRxiv	2023
36646198	Evaluation of the association between circulating IL-1Î² and other inflammatory cytokines and incident atrial fibrillation in a cohort of postmenopausal women.		2023
37133828	Cardiovascular Disease Risk Assessment Using Traditional Risk Factors and Polygenic Risk Scores in the Million Veteran Program.	JAMA Cardiol	2023
36930136	Cardiovascular Disease and Mortality inÂ Black Women Carrying the Amyloidogenic V122I Transthyretin GeneÂ Variant.		2023
37425708	Diversity and Scale: Genetic Architecture of 2,068 Traits in the VA Million Veteran Program.	medRxiv	2023
35222515	Genetic Loci Associated With COVID-19 Positivity and Hospitalization in White, Black, and Hispanic Veterans of the VA Million Veteran Program.	Front Genet	2022
36374587	Fibromuscular Dysplasia and Abdominal Aortic Aneurysms Are Dimorphic Sex-Specific Diseases With Shared Complex Genetic Architecture.	Circ Genom Precis Med	2022
35654975	A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation.	Nat Genet	2022
35653334	A multi-population phenome-wide association study of genetically-predicted height in the Million Veteran Program.	PLoS Genet	2022
35588732	Integration of rare expression outlier-associated variants improves polygenic risk prediction.	Am J Hum Genet	2022
35652341	Insights From a Large-Scale Whole-Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension.	Hypertension	2022
36034645	Broad clinical manifestations of polygenic risk for coronary artery disease in the Women's Health Initiative.	Commun Med (Lond)	2022
35387486	Genetic Landscape of the ACE2 Coronavirus Receptor.	Circulation	2022
35385311	Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential.	Sci Adv	2022
35500859	Gaseous air pollutants and DNA methylation in a methylome-wide association study of an ethnically and environmentally diverse population of U.S. adults.	Environ Res	2022
35796859	Use of Polygenic Risk Scores for Coronary Heart Disease in Ancestrally Diverse Populations.	Curr Cardiol Rep	2022
36064543	A translational genomics approach identifies IL10RB as the top candidate gene target for COVID-19 susceptibility.	NPJ Genom Med	2022
35986173	Understanding the comorbidity between posttraumatic stress severity and coronary artery disease using genome-wide information and electronic health records.	Mol Psychiatry	2022
35861770	Race and Ethnicity Stratification for Polygenic Risk Score Analyses May Mask Disparities in Hispanics.	Circulation	2022
35915156	Large-scale genome-wide association study of coronary artery disease in genetically diverse populations.	Nat Med	2022
35716666	Genetic interactions drive heterogeneity in causal variant effect sizes for gene expression and complex traits.	Am J Hum Genet	2022
34990206	<i>ZEB2</i> Shapes the Epigenetic Landscape of Atherosclerosis.	Circulation	2022
35293152	Interactions of physical activity, muscular fitness, adiposity, and genetic risk for NAFLD.	Hepatol Commun	2022
34727735	Whole-Genome Sequencing Association Analyses of Stroke and Its Subtypes in Ancestrally Diverse Populations From Trans-Omics for Precision Medicine Project.	Stroke	2022
35186008	Multi-Trait Genome-Wide Association Study of Atherosclerosis Detects Novel Pleiotropic Loci.	Front Genet	2022
35143253	Coronary Artery Disease Risk of Familial Hypercholesterolemia Genetic Variants Independent of Clinically Observed Longitudinal Cholesterol Exposure.	Circ Genom Precis Med	2022
34479738	DXA Versus Clinical Measures of Adiposity as Predictors of Cardiometabolic Diseases and All-Cause Mortality in Postmenopausal Women.	Mayo Clin Proc	2021
34079032	Association of the transthyretin variant V122I with polyneuropathy among individuals of African ancestry.	Sci Rep	2021
34230475	Publisher Correction: A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids.	Nat Commun	2021
33853351	Association Between Genetic Variation in Blood Pressure and Increased Lifetime Risk of Peripheral Artery Disease.	Arterioscler Thromb Vasc Biol	2021
33851187	Mendelian randomisation identifies alternative splicing of the FAS death receptor as a mediator of severe COVID-19.	medRxiv	2021
34282949	Associations of Genetically Predicted Lp(a) (Lipoprotein [a]) Levels With Cardiovascular Traits in Individuals of European and African Ancestry.	Circ Genom Precis Med	2021
33895111	Epigenetically mediated electrocardiographic manifestations of sub-chronic exposures to ambient particulate matter air pollution in the Women's Health Initiative and Atherosclerosis Risk in Communities Study.	Environ Res	2021
34050697	Clonal hematopoiesis associated with epigenetic aging and clinical outcomes.	Aging Cell	2021
34100031	IL10RB as a key regulator of COVID-19 host susceptibility and severity.	medRxiv	2021
34183656	A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids.	Nat Commun	2021
33354722	Epigenome-wide association study of diet quality in the Women's Health Initiative and TwinsUK cohort.	Int J Epidemiol	2021
32847391	Mendelian Randomization Analysis of Hemostatic Factors and Their Contribution to Peripheral Artery Disease-Brief Report.	Arterioscler Thromb Vasc Biol	2021