Skip to Main Content

Author Details

Lisa M Ellerby
Buck Institute for Research on Aging
1990
100
53
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37586438Therapeutic targeting of HYPDH/PRODH2 with N-propargylglycine offers a Hyperoxaluria treatment opportunity.Biochim Biophys Acta Mol Basis Dis2024
36950837Molecular and Cellular Crosstalk between Bone and Brain: Accessing Bidirectional Neural and Musculoskeletal Signaling during Aging and Disease.J Bone Metab2023
36289639Postnatal Conditional Deletion of <i>Bcl11b</i> in Striatal Projection Neurons Mimics the Transcriptional Signature of Huntington's Disease.Biomedicines2022
35424746PNA microprobe for label-free detection of expanded trinucleotide repeats.RSC Adv2022
34024231Modulating FKBP5/FKBP51 and autophagy lowers HTT (huntingtin) levels.Autophagy2021
33663567Pluripotent stem cell-derived models of neurological diseases reveal early transcriptional heterogeneity.Genome Biol2021
34609283Unbiased identification of novel transcription factors in striatal compartmentation and striosome maturation.Elife2021
34403156Striatal Cholinergic Dysregulation after Neonatal Decrease in X-Linked Dystonia Parkinsonism-Related TAF1 Isoforms.Mov Disord2021
34089390N-Propargylglycine: a unique suicide inhibitor of proline dehydrogenase with anticancer activity and brain-enhancing mitohormesis properties.Amino Acids2021
34286353Correction to: N-Propargylglycine: a unique suicide inhibitor of proline dehydrogenase with anticancer activity and brain-enhancing mitohormesis properties.Amino Acids2021
34081916Neuronal intranuclear inclusion disease: Polyglycine protein is the culprit.Neuron2021
33156570FOXO3 targets are reprogrammed as Huntington's disease neural cells and striatal neurons face senescence with p16<sup>INK4a</sup> increase.Aging Cell2020
31894829Characterization and application of fluidic properties of trinucleotide repeat sequences by wax-on-plastic microfluidics.J Mater Chem B2020
30594931Rac1 Activity Is Modulated by Huntingtin and Dysregulated in Models of Huntington's Disease.J Huntingtons Dis2019
31907874Repeat Expansion Disorders: Mechanisms and Therapeutics.Neurotherapeutics2019
31792895Modeling Polyglutamine Expansion Diseases with Induced Pluripotent Stem Cells.Neurotherapeutics2019
31435686Novel probes for label-free detection of neurodegenerative GGGGCC repeats associated with amyotrophic lateral sclerosis.Anal Bioanal Chem2019
31541002Nuclear Receptor Nr4a1 Regulates Striatal Striosome Development and Dopamine D<sub>1</sub> Receptor Signaling.eNeuro2019
30994454Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription.Elife2019
29459817Altered Expression of Matrix Metalloproteinases and Their Endogenous Inhibitors in a Human Isogenic Stem Cell Model of Huntington's Disease.Front Neurosci2018
28533375KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients.Proc Natl Acad Sci U S A2017
27041503Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss.Neuron2016
26428226iPSC-based drug screening for Huntington's disease.Brain Res2016
26025364Integration-independent Transgenic Huntington Disease Fragment Mouse Models Reveal Distinct Phenotypes and Life Span in Vivo.J Biol Chem2015
26651603Genomic Analysis Reveals Disruption of Striatal Neuronal Development and Therapeutic Targets in Human Huntington's Disease Neural Stem Cells.Stem Cell Reports2015
26390242Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits.Nat Med2015
25859008Proteolytic cleavage of ataxin-7 promotes SCA7 retinal degeneration and neurological dysfunction.Hum Mol Genet2015
24761311Polyglutamine Disease Modeling: Epitope Based Screen for Homologous Recombination using CRISPR/Cas9 System.PLoS Curr2014
24160175Histone deacetylase-3 interacts with ataxin-7 and is altered in a spinocerebellar ataxia type 7 mouse model.Mol Neurodegener2013
22649225Caspase-6 activity in a BACHD mouse modulates steady-state levels of mutant huntingtin protein but is not necessary for production of a 586 amino acid proteolytic fragment.J Neurosci2012
23393546Pizotifen Activates ERK and Provides Neuroprotection in vitro and in vivo in Models of Huntington's Disease.J Huntingtons Dis2012
23209424A genome-scale RNA-interference screen identifies RRAS signaling as a pathologic feature of Huntington's disease.PLoS Genet2012
22966490Guidelines for the use and interpretation of assays for monitoring autophagy.Autophagy2012
22748967Genetic correction of Huntington's disease phenotypes in induced pluripotent stem cells.Cell Stem Cell2012
22917535Responses of human embryonic stem cells and their differentiated progeny to ionizing radiation.Biochem Biophys Res Commun2012
22511757Inhibition of lipid signaling enzyme diacylglycerol kinase epsilon attenuates mutant huntingtin toxicity.J Biol Chem2012
21685499Mass spectrometric identification of novel lysine acetylation sites in huntingtin.Mol Cell Proteomics2011
20104018Autophagy: polyQ toxic fragment turnover.Autophagy2010
21037797Characterization of Human Huntington's Disease Cell Model from Induced Pluripotent Stem Cells.PLoS Curr2010
21095569Identification and evaluation of small molecule pan-caspase inhibitors in Huntington's disease models.Chem Biol2010
20670829Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease.Neuron2010
20086007Proteolysis of mutant huntingtin produces an exon 1 fragment that accumulates as an aggregated protein in neuronal nuclei in Huntington disease.J Biol Chem2010
19228953Polyglutamine-expanded androgen receptor truncation fragments activate a Bax-dependent apoptotic cascade mediated by DP5/Hrk.J Neurosci2009
19955365Posttranslational modification of ataxin-7 at lysine 257 prevents autophagy-mediated turnover of an N-terminal caspase-7 cleavage fragment.J Neurosci2009
19617626Calpain-1 cleaves and activates caspase-7.J Biol Chem2009
19679066IGF-1: elixir for motor neuron diseases.Neuron2009
17394466Mitochondrial dysfunction in Huntington's disease: the bioenergetics of isolated and in situ mitochondria from transgenic mice.J Neurochem2007
17537594A neuroglobin-overexpressing transgenic mouse.Gene2007
17646170Proteolytic cleavage of ataxin-7 by caspase-7 modulates cellular toxicity and transcriptional dysregulation.J Biol Chem2007
17500595Huntingtin interacting proteins are genetic modifiers of neurodegeneration.PLoS Genet2007
  • 1 - 50 of 100

Recommended Authors

Jeha Jeon
Department of Psychiatry and McLean Hospital, Harvard Medical School
Career Start Year 2014
Number of shared co-authors 0
Mathieu Bourdenx
University College London, UK Dementia Research Institute
Career Start Year 2013
Number of shared co-authors 11
Ulrike Kr??ger
Berlin Institute of Health (BIH)
Career Start Year 2007
Number of shared co-authors 2
Laura Ru??
Department of Pharmaceutical and Pharmacological Sciences
Career Start Year 2007
Number of shared co-authors 0
Nicolas Casadei
Institute of Medical Genetics and Applied Genomics, University of Tubingen
Career Start Year 2007
Number of shared co-authors 1
Kelly E Glajch
Neurodegenerative Diseases Research Unit
Career Start Year 2006
Number of shared co-authors 1
Karen N McFarland
Center for Translational Research in Neurodegenerative Disease, University of Florida
Career Start Year 2005
Number of shared co-authors 1
Merina Varghese
Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
Career Start Year 2005
Number of shared co-authors 1
Caroline L Benn
Pfizer Neuroscience and Pain Research Unit, Pfizer Ltd.
Career Start Year 2004
Number of shared co-authors 2
Julia A Kaye
J. David Gladstone Institutes
Career Start Year 2004
Number of shared co-authors 2
Ghazaleh Sadri-Vakili
Sean M. Healey & AMG Center for ALS at Mass General
Career Start Year 2003
Number of shared co-authors 4
Fang Cai
Department of Pharmacy, Fuzhou Second Hospital
Career Start Year 2003
Number of shared co-authors 0
Byoung-Il Bae
University of Connecticut School of Medicine
Career Start Year 2000
Number of shared co-authors 5
Eftekhar Eftekharpour
University of Manitoba
Career Start Year 2000
Number of shared co-authors 1
Aaron D Gitler
Stanford University School of Medicine
Career Start Year 1999
Number of shared co-authors 8
Joshua M Shulman
Baylor College of Medicine
Career Start Year 1998
Number of shared co-authors 5
Sami J Barmada
University of Michigan ann arbor
Career Start Year 1997
Number of shared co-authors 5
Stephan Frank
Universitatsspital Basel
Career Start Year 1996
Number of shared co-authors 0
Jose Antonio Rodriguez
University of the Basque Country (UPV/EHU)
Career Start Year 1995
Number of shared co-authors 11
Hyemyung Seo
Center for Bionano Intelligence Education and Research, Hanyang University
Career Start Year 1995
Number of shared co-authors 2
Suman Jayadev
University of Washington
Career Start Year 1995
Number of shared co-authors 2
Claudia Crosio
University of Sassari
Career Start Year 1994
Number of shared co-authors 5
Ruth Luthi-Carter
University of Leicester
Career Start Year 1992
Number of shared co-authors 5
Sandrine Humbert
Grenoble Institut Neurosciences, INSERM, Universite Grenoble Alpes
Career Start Year 1992
Number of shared co-authors 4
Diego E Rincon-Limas
University of Florida
Career Start Year 1990
Number of shared co-authors 1
Eric J Huang
University of California san francisco
Career Start Year 1990
Number of shared co-authors 14
William T Dauer
Peter O'Donnell Jr. Brain Institute
Career Start Year 1988
Number of shared co-authors 9
Jang-Ho J Cha
Novartis Institutes for Biomedical Research
Career Start Year 1986
Number of shared co-authors 3
Christian Haass
German Center for Neurodegenerative Diseases (DZNE) Munich
Career Start Year 1981
Number of shared co-authors 0
Virginia M-Y Lee
Perelman School of Medicine at the University of Pennsylvania
Career Start Year 1977
Number of shared co-authors 16

Collaborators

Michael R Hayden
Co-authored papers 11
Birgit Schilling
Buck Institute for Research on Aging
Co-authored papers 7
Bradford W Gibson
The Buck Institute for Research on Aging
Co-authored papers 6
Xin Cong
Jiangsu Simcere Pharmaceutical Co. Ltd.
Co-authored papers 6
Michelle E Ehrlich
Icahn School of Medicine at Mount Sinai
Co-authored papers 6
Roshni R Singaraja
Co-authored papers 5
Sean D Mooney
University of Washington
Co-authored papers 5
Juan Botas
Baylor College of Medicine
Co-authored papers 4
Stan Krajewski
Cellstan-Immunoquant Inc.
Co-authored papers 4
Christopher C Benz
Buck Institute for Research on Aging
Co-authored papers 3
David A Greenberg
Abigail Wexner Research Institute, Nationwide Children's Hospital
Co-authored papers 3
Wadih Arap
Rutgers Cancer Institute of New Jersey
Co-authored papers 2
Tara E Tracy
Buck Institute for Research on Aging
Co-authored papers 2
Sang-Won Min
Gladstone Institutes
Co-authored papers 2
Steven Finkbeiner
J. David Gladstone Institutes
Co-authored papers 2
Renata Pasqualini
Rutgers Cancer Institute of New Jersey
Co-authored papers 2
Sakura Minami
Dokkyo Medical University
Co-authored papers 2
Madeleine K D Scott
Co-authored papers 2
Jason M Held
Co-authored papers 2
Leslie M Thompson
Co-authored papers 2
Peter Dongmin Sohn
Gladstone Institutes
Co-authored papers 2
Yaqiao Li
Harvard Medical School
Co-authored papers 2
Donald C Lo
National Center for Advancing Translational Sciences
Co-authored papers 2
Chao Wang
Gladstone Institutes
Co-authored papers 2
Simon Melov
Buck Institute for Research on Aging
Co-authored papers 2
Jason E Gestwicki
Institute for Neurodegenerative Diseases, University of California San Francisco
Co-authored papers 2
Li Gan
Helen and Robert Appel Alzheimer's Disease Research Institute
Co-authored papers 2
Steven M Hersch
Inc. University Avenue
Co-authored papers 2
Yungui Zhou
Gladstone Institutes
Co-authored papers 2
Akiko Iwasaki
Yale University
Co-authored papers 1
Release 1.2