Author details

Full Name

Michel L Tremblay

Affiliation

ORCID

Career Start Year

1983

Papers

219

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37400834	TAOK3 limits age-associated inflammation by negatively modulating macrophage differentiation and their production of TNFÎ±.		2023
36441193	Pharmacological potentiation of monocyte-derived dendritic cell cancer immunotherapy.	Cancer Immunology, Immunotherapy	2023
37673461	Advancing therapeutics using antibody-induced dimerization of receptor tyrosine phosphatases.		2023
36972446	PRL-1/2 phosphatases control TRPM7 magnesium-dependent function to regulate cellular bioenergetics.		2023
35193953	Stress-induced tyrosine phosphorylation of RtcB modulates IRE1 activity and signaling outputs.	Life Science Alliance	2022
35439023	Protein tyrosine phosphatase 1B regulates miR-208b-argonaute 2 association and thyroid hormone responsiveness in cardiac hypertrophy.	Sci Signal	2022
35999262	Brief exposure of neuronal cells to levels of SCFAs observed in human systemic circulation impair lipid metabolism resulting in apoptosis.	Scientific Reports	2022
36433951	Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage.	Nature Communications	2022
33563644	Autoimmune susceptibility gene is required for clearance of adherent-invasive by integrating bacterial uptake and lysosomal defence.	Gut	2022
34623320	T cell protein tyrosine phosphatase protects intestinal barrier function by restricting epithelial tight junction remodeling.	J Clin Invest	2021
34169549	Protein tyrosine phosphatome metabolic screen identifies TC-PTP as a positive regulator of cancer cell bioenergetics and mitochondrial dynamics.	FASEB Journal	2021
34214487	Lesch-Nyhan disease causes impaired energy metabolism and reduced developmental potential in midbrain dopaminergic cells.	Stem Cell Reports	2021
34089346	ARL15 modulates magnesium homeostasis through N-glycosylation of CNNMs.	Cellular and Molecular Life Sciences	2021
33055428	PTPN2 links colonic and joint inflammation in experimental autoimmune arthritis.	JCI Insight	2020
32213561	4E-BP-Dependent Translational Control of Mediates Adipose Tissue Macrophage Inflammatory Response.	Journal of Immunology	2020
33097786	PRL-2 phosphatase is required for vascular morphogenesis and angiogenic signaling.	Communications Biology	2020
32587106	Elevated V-ATPase Activity Following PTEN Loss Is Required for Enhanced Oncogenic Signaling in Breast Cancer.	Molecular Cancer Research	2020
32586195	The autoimmune susceptibility gene, , restricts expansion of a novel mouse adherent-invasive .	Gut Microbes	2020
32637608	Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal.	Sci Adv	2020
32852310	Mechanisms of invasion in glioblastoma.	Current Opinion in Oncology	2020
33330862	Identification of a Novel Susceptibility Marker for SARS-CoV-2 Infection in Human Subjects and Risk Mitigation with a Clinically Approved JAK Inhibitor in Human/Mouse Cells.	bioRxiv	2020
31532798	PTP1B negatively regulates nitric oxide-mediated Pseudomonas aeruginosa killing by neutrophils.	PLoS ONE	2019
31842432	Structural Insights into the Intracellular Region of the Human Magnesium Transport Mediator CNNM4.	International Journal of Molecular Sciences	2019
30620725	Reduced expression of phosphatase PTPN2 promotes pathogenic conversion of Tregs in autoimmunity.	J Clin Invest	2019
30718434	Magnesium-sensitive upstream ORF controls PRL phosphatase expression to mediate energy metabolism.	Proceedings of the National Academy of Sciences of the United States of America	2019
28287113	Loss of T-cell protein tyrosine phosphatase in the intestinal epithelium promotes local inflammation by increasing colonic stem cell proliferation.	Cellular and Molecular Immunology	2018
30429852	Protein Tyrosine Phosphatases: Regulators of CD4 T Cells in Inflammatory Bowel Disease.	Frontiers in Immunology	2018
29770564	Physiological and oncogenic roles of the PRL phosphatases.		2018
27897403	New genetic signatures associated with cancer cachexia as defined by low skeletal muscle index and weight loss.	J Cachexia Sarcopenia Muscle	2017
28559011	Protein tyrosine phosphatase Ï¿ regulates autoimmune encephalomyelitis development.	Brain, Behavior, and Immunity	2017
28558026	Identification of function-regulating antibodies targeting the receptor protein tyrosine phosphatase sigma ectodomain.	PLoS ONE	2017
28680757	Downregulation of PTP1B and TC-PTP phosphatases potentiate dendritic cell-based immunotherapy through IL-12/IFNÎ³ signaling.	Oncoimmunology	2017
28679948	PRL2 links magnesium flux and sex-dependent circadian metabolic rhythms.	JCI insight	2017
28929190	Mining the Complex Family of Protein Tyrosine Phosphatases for Checkpoint Regulators in Immunity.	Current Topics in Microbiology and Immunology	2017
29038451	TC-PTP regulates the IL-7 transcriptional response during murine early T cell development.	Scientific Reports	2017
27899452	Structural Basis of the Oncogenic Interaction of Phosphatase PRL-1 with the Magnesium Transporter CNNM2.	Journal of Biological Chemistry	2017
26644181	PTP-PEST controls EphA3 activation and ephrin-induced cytoskeletal remodelling.	Journal of Cell Science	2016
27020859	PTP1B Deficiency Enables the Ability of a High-Fat Diet to Drive the Invasive Character of PTEN-Deficient Prostate Cancers.	Cancer Research	2016
27105736	Protein Tyrosine Phosphatase-1B Negatively Impacts Host Defense against Pseudomonas aeruginosa Infection.	American Journal of Pathology	2016
27015884	Localizing PRL-2 expression and determining the effects of dietary Mg(2+) on expression levels.	Histochemistry and Cell Biology	2016
26969161	Inhibition of PRL-2Â·CNNM3 Protein Complex Formation Decreases Breast Cancer Proliferation and Tumor Growth.	Journal of Biological Chemistry	2016
26954714	Identification of neutrophil-derived proteases and angiotensin II as biomarkers of cancer cachexia.	British Journal of Cancer	2016
27402251	ERRÎ± mediates metabolic adaptations driving lapatinib resistance in breast cancer.	Nat Commun	2016
27311921	Protein tyrosine phosphatase 1B (PTP1B) is dispensable for IgE-mediated cutaneous reaction in vivo.	Cellular Immunology	2016
26817397	TC-PTP and PTP1B: Regulating JAK-STAT signaling, controlling lymphoid malignancies.	Cytokine	2016
24632616	The protein tyrosine phosphatase PRL-2 interacts with the magnesium transporter CNNM3 to promote oncogenesis.	Oncogene	2015
25586181	UBC9-dependent association between calnexin and protein tyrosine phosphatase 1B (PTP1B) at the endoplasmic reticulum.	Journal of Biological Chemistry	2015
25771859	A Drosophila-centric view of protein tyrosine phosphatases.	FEBS Letters	2015
25381555	Deletion of the gene encoding G0/G 1 switch protein 2 (G0s2) alleviates high-fat-diet-induced weight gain and insulin resistance, and promotes browning of white adipose tissue in mice.	Diabetologia	2015
26231120	Protein Tyrosine Phosphatase PTPRS Is an Inhibitory Receptor on Human and Murine Plasmacytoid Dendritic Cells.	Immunity	2015