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Author Details

Philip A Cole
Brigham and Women's Hospital, Blavatnik Institute, Harvard Medical School
1990
244
77
Prashant Mali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36584580KATs off: Biomedical insights from lysine acetyltransferase inhibitors.Curr Opin Chem Biol2023
34610961Epigenetic Silencing of BMP6 by the SIN3A-HDAC1/2 Repressor Complex Drives Melanoma Metastasis via FAM83G/PAWS1.Mol Cancer Res2022
35968932PH domain-mediated autoinhibition and oncogenic activation of Akt.Elife2022
34941261Multifaceted Regulation of Akt by Diverse C-Terminal Post-translational Modifications.ACS Chem Biol2022
35331737Enzymatic analysis of WWP2 E3 ubiquitin ligase using protein microarrays identifies autophagy-related substrates.J Biol Chem2022
33470109Ubiquitin Ligase Activities of WWP1 Germline Variants K740N and N745S.Biochemistry2021
33627428The regulatory enzymes and protein substrates for the lysine β-hydroxybutyrylation pathway.Sci Adv2021
33907245HDAC2 targeting stabilizes the CoREST complex in renal tubular cells and protects against renal ischemia/reperfusion injury.Sci Rep2021
33631370Discovery of spirohydantoins as selective, orally bioavailable inhibitors of p300/CBP histone acetyltransferases.Bioorg Med Chem Lett2021
34634172Site-Specific 5-Formyl Cytosine Mediated DNA-Histone Cross-Links: Synthesis and Polymerase Bypass by Human DNA Polymerase η.Angew Chem Int Ed Engl2021
34625746The structural basis of PTEN regulation by multi-site phosphorylation.Nat Struct Mol Biol2021
34622806p300 suppresses the transition of myelodysplastic syndromes to acute myeloid leukemia.JCI Insight2021
34285087Chemical Screen Identifies Diverse and Novel Histone Deacetylase Inhibitors as Repressors of NUT Function: Implications for NUT Carcinoma Pathogenesis and Treatment.Mol Cancer Res2021
31206229Analysis of Site-Specific Phosphorylation of PTEN by Using Enzyme-Catalyzed Expressed Protein Ligation.Chembiochem2020
31704733Lysine-Specific Demethylase 1 Mediates AKT Activity and Promotes Epithelial-to-Mesenchymal Transition in <i>PIK3CA</i>-Mutant Colorectal Cancer.Mol Cancer Res2020
32101746Mechanism of Crosstalk between the LSD1 Demethylase and HDAC1 Deacetylase in the CoREST Complex.Cell Rep2020
31917688Inhibiting the coregulator CoREST impairs Foxp3+ Treg function and promotes antitumor immunity.J Clin Invest2020
32744507The structural determinants of PH domain-mediated regulation of Akt revealed by segmental labeling.Elife2020
32869031Elucidation of remdesivir cytotoxicity pathways through genome-wide CRISPR-Cas9 screening and transcriptomics.bioRxiv2020
32698016The Chemical Biology of Reversible Lysine Post-translational Modifications.Cell Chem Biol2020
32475408Selective protein N-terminal labeling with N-hydroxysuccinimide esters.Methods Enzymol2020
32501215Diverse nucleosome Site-Selectivity among histone deacetylase complexes.Elife2020
32144660Methods and Applications of Expressed Protein Ligation.Methods Mol Biol2020
32541877The protein kinase Akt acts as a coat adaptor in endocytic recycling.Nat Cell Biol2020
32371576Combined Targeting of the BRD4-NUT-p300 Axis in NUT Midline Carcinoma by Dual Selective Bromodomain Inhibitor, NEO2734.Mol Cancer Ther2020
30901610AKTivation mechanisms.Curr Opin Struct Biol2019
31653360Editorial overview: Biological catalysis at the cross-roads of signaling and metabolism.Curr Opin Struct Biol2019
31182641CREB Promotes Beta Cell Gene Expression by Targeting Its Coactivators to Tissue-Specific Enhancers.Mol Cell Biol2019
31578285Comparative analysis of the catalytic regulation of NEDD4-1 and WWP2 ubiquitin ligases.J Biol Chem2019
31631026Re-programing Chromatin with a Bifunctional LSD1/HDAC Inhibitor Induces Therapeutic Differentiation in DIPG.Cancer Cell2019
30924641Combination Targeting of the Bromodomain and Acetyltransferase Active Site of p300/CBP.Biochemistry2019
30865688Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model.PLoS One2019
30704096Getting the Most Out of Your Crystals: Data Collection at the New High-Flux, Microfocus MX Beamlines at NSLS-II.Molecules2019
31003455Complementary Roles of GCN5 and PCAF in Foxp3+ T-Regulatory Cells.Cancers (Basel)2019
30910803MITF Expression Predicts Therapeutic Vulnerability to p300 Inhibition in Human Melanoma.Cancer Res2019
29341593Analysis of Cellular Tyrosine Phosphorylation via Chemical Rescue of Conditionally Active Abl Kinase.Biochemistry2018
29917162N-terminal domain of human uracil DNA glycosylase (hUNG2) promotes targeting to uracil sites adjacent to ssDNA-dsDNA junctions.Nucleic Acids Res2018
30078705Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis.Cell2018
29804834Time-Resolved Analysis Reveals Rapid Dynamics and Broad Scope of the CBP/p300 Acetylome.Cell2018
29991262Hydrazide Mimics for Protein Lysine Acylation To Assess Nucleosome Dynamics and Deubiquitinase Action.J Am Chem Soc2018
30016585Site-Specific Protein Labeling with N-Hydroxysuccinimide-Esters and the Analysis of Ubiquitin Ligase Mechanisms.J Am Chem Soc2018
30149868Protein Chemical Approaches to Understanding PTEN Lipid Phosphatase Regulation.Methods Enzymol2018
29869982Lysine-14 acetylation of histone H3 in chromatin confers resistance to the deacetylase and demethylase activities of an epigenetic silencing complex.Elife2018
29769713Author Correction: Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours.Nature2018
29302039Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors.Nat Commun2018
28787572Disordered N-Terminal Domain of Human Uracil DNA Glycosylase (hUNG2) Enhances DNA Translocation.ACS Chem Biol2017
28475870A Tunable Brake for HECT Ubiquitin Ligases.Mol Cell2017
28288122Genetically encoded biosensors for visualizing live-cell biochemical activity at super-resolution.Nat Methods2017
29036472Measurement of nanoscale DNA translocation by uracil DNA glycosylase in human cells.Nucleic Acids Res2017
29056321CBP Regulates Recruitment and Release of Promoter-Proximal RNA Polymerase II.Mol Cell2017
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Collaborators

David J Meyers
Johns Hopkins School of Medicine
Co-authored papers 19
Ronen Marmorstein
Perelman School of Medicine, University of Pennsylvania
Co-authored papers 14
Chandrani Mukherjee
Co-authored papers 8
Akhilesh Pandey
Co-authored papers 7
Jin Zhang
Co-authored papers 6
Ron Bose
Washington University School of Medicine
Co-authored papers 6
Mingxuan Wu
Co-authored papers 6
Keykavous Parang
Co-authored papers 6
Robert J Cotter
Co-authored papers 6
Kenneth D Bromberg
Co-authored papers 5
John Kuriyan
University of California berkeley
Co-authored papers 5
Robert G Roeder
the Rockefeller University
Co-authored papers 5
Jef D Boeke
Institute for Systems Genetics, NYU School of Medicine
Co-authored papers 5
Henrik Molina
Co-authored papers 4
Stefani N Thomas
Co-authored papers 3
Melanie Ott
Gladstone Institute of Virology
Co-authored papers 3
Yoshihiro Nakatani
Dana Farber Cancer Institute
Co-authored papers 3
Jiang Qian
Co-authored papers 3
Chunaram Choudhary
The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen
Co-authored papers 3
Jeffrey J Gray
Johns Hopkins University
Co-authored papers 3
Stephen K Burley
The State University of New Jersey
Co-authored papers 2
Mitzi I Kuroda
Co-authored papers 2
Vittorio Sartorelli
Co-authored papers 2
Alex Vassilev
National Institute of Child Health & Human Development, National Institutes of Health
Co-authored papers 2
John P Giddens
Co-authored papers 2
Jeliazko R Jeliazkov
Co-authored papers 2
Neil L Kelleher
Northwestern University
Co-authored papers 2
Tamar Uziel
AbbVie Inc.
Co-authored papers 2
Peter N Devreotes
Co-authored papers 2
Lihua Jiang
Stanford University
Co-authored papers 2
Release 1.2