Author details

Full Name

Thaddeus S Stappenbeck

Affiliation

ORCID

Career Start Year

1987

Papers

175

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37292732	Microbiota produced indole metabolites disrupt host cell mitochondrial energy production and inhibit growth.		2023
35816130	The Current State of Care for Black and Hispanic Inflammatory Bowel Disease Patients.	Inflamm Bowel Dis	2023
36191961	NOX1 is essential for TNFÎ±-induced intestinal epithelial ROS secretion and inhibits M cell signatures.	Gut	2023
37874328	Periprosthetic joint infection and immunity: Current understanding of host-microbe interplay.		2023
37776865	Select symbionts drive high IgA levels in the mouse intestine.		2023
37693422	<i>Cryptosporidium</i> infection of human small intestinal epithelial cells induces type III interferon and impairs infectivity of Rotavirus.	bioRxiv	2023
37384526	Microbiota-produced indole metabolites disrupt mitochondrial function and inhibit Cryptosporidium parvum growth.		2023
37037942	Uropathogenic Escherichia coli infection-induced epithelial trained immunity impacts urinary tract disease outcome.	Nat Microbiol	2023
35016013	Adaptive differentiation promotes intestinal villus recovery.	Developmental Cell	2022
35584642	Paying attention to minutiae: Strain level differences drive disease etiology.	Med	2022
35636923	Organoids in gastrointestinal diseases: from experimental models to clinical translation.	Gut	2022
35868637	Mesothelium-Derived Factors Shape GATA6-Positive Large Cavity Macrophages.	Journal of Immunology	2022
35617395	Local barriers configure systemic communications between the host and microbiota.	Science	2022
35534698	HOIL1 regulates group 2 innate lymphoid cell numbers and type 2 inflammation in the small intestine.	Mucosal Immunology	2022
34261752	Reverse translation approach generates a signature of penetrating fibrosis in Crohn's disease that is associated with anti-TNF response.	Gut	2022
34424745	Biofilm Formation and Virulence of Shigella flexneri Are Modulated by pH of Gastrointestinal Tract.	Infection and Immunity	2021
33707263	<i>Debaryomyces</i> is enriched in Crohn's disease intestinal tissue and impairs healing in mice.	Science	2021
33636133	Enteric helminth coinfection enhances host susceptibility to neurotropic flaviviruses via a tuft cell-IL-4 receptor signaling axis.	Cell	2021
34010595	Western diet induces Paneth cell defects through microbiome alterations and farnesoid X receptor and type I interferon activation.	Cell Host Microbe	2021
33930605	HER2 and APC Mutations Promote Altered Crypt-Villus Morphology and Marked Hyperplasia in the Intestinal Epithelium.	Cell Mol Gastroenterol Hepatol	2021
32964238	Epithelial Cell Biomarkers Are Predictive of Response to Biologic Agents in Crohn's Disease.	Inflammatory Bowel Diseases	2021
33160965	Altered Intestinal ACE2 Levels Are Associated With Inflammation, Severe Disease, and Response to Anti-Cytokine Therapy in Inflammatory Bowel Disease.	Gastroenterology	2021
34462359	Chronic infection enhances susceptibility to colitis.	Proceedings of the National Academy of Sciences of the United States of America	2021
31452172	In Vitro Culture of Cryptosporidium parvum Using Stem Cell-Derived Intestinal Epithelial Monolayers.	Methods in Molecular Biology	2020
31900343	Polysaccharide Capsules Equip the Human Symbiont to Modulate Immune Responses to a Dominant Antigen in the Intestine.	Journal of Immunology	2020
31900338	BHLHE40 Promotes T2 Cell-Mediated Antihelminth Immunity and Reveals Cooperative CSF2RB Family Cytokines.	Journal of Immunology	2020
33603730	Apurinic/Apyrimidinic Endonuclease 1 Restricts the Internalization of Bacteria Into Human Intestinal Epithelial Cells Through the Inhibition of Rac1.	Frontiers in Immunology	2020
33156843	A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19.	PLoS Biol	2020
32511625	Reduced expression of COVID-19 host receptor, <i>ACE2</i> is associated with small bowel inflammation, more severe disease, and response to anti-TNF therapy in Crohn's disease.	medRxiv	2020
32676577	A Network Medicine Approach to Investigation and Population-based Validation of Disease Manifestations and Drug Repurposing for COVID-19.	ChemRxiv	2020
32668198	The Intestinal Microbiome Restricts Alphavirus Infection and Dissemination through a Bile Acid-Type I IFN Signaling Axis.	Cell	2020
33323514	Neonatal Mouse Gut Metabolites Influence Cryptosporidium parvum Infection in Intestinal Epithelial Cells.	mBio	2020
30877309	Ileal Gene Expression Data from Crohn's Disease Small Bowel Resections Indicate Distinct Clinical Subgroups.	J Crohns Colitis	2019
31708126	Long-Term Culture Captures Injury-Repair Cycles of Colonic Stem Cells.	Cell	2019
29695840	A screen of Crohn's disease-associated microbial metabolites identifies ascorbate as a novel metabolic inhibitor of activated human T cells.	Mucosal Immunol	2019
30737355	Diet modulates colonic T cell responses by regulating the expression of a antigen.	Science immunology	2019
30677624	Microbiome control of innate reactivity.		2019
31116580	Autophagy proteins are required for club cell structure and function in airways.	American Journal of Physiology - Lung Cellular and Molecular Physiology	2019
31061528	Bhlhe40 mediates tissue-specific control of macrophage proliferation in homeostasis and type 2 immunity.	Nature Immunology	2019
30894050	protects the intestinal epithelium from TNF-triggered villus atrophy.		2019
30842312	PAI-1 augments mucosal damage in colitis.	Sci Transl Med	2019
31095706	Challenges in IBD Research: Preclinical Human IBD Mechanisms.	Inflamm Bowel Dis	2019
30933720	L-WRN conditioned medium for gastrointestinal epithelial stem cell culture shows replicable batch-to-batch activity levels across multiple research teams.	Stem Cell Research	2019
29727673	Intestinal Stem Cells Live Off the Fat of the Land.		2018
30122655	Temporal Regulation of the Bacterial Metabolite Deoxycholate during Colonic Repair Is Critical for Crypt Regeneration.		2018
30106382	Survival signal REG3Î± prevents crypt apoptosis to control acute gastrointestinal graft-versus-host disease.	Journal of Clinical Investigation	2018
30250879	Cellular differentiation: Potential insight into butyrate paradox?	Molecular and Cellular Oncology	2018
30293866	Intestinal Dysmotility Syndromes following Systemic Infection by Flaviviruses.	Cell	2018
30137026	Interaction between smoking and ATG16L1T300A triggers Paneth cell defects in Crohn's disease.	J Clin Invest	2018
29994669	Deep Learning Global Glomerulosclerosis in Transplant Kidney Frozen Sections.	IEEE Trans Med Imaging	2018