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Author Details

Rubin Lubomirov
Clinical Development
2003
35
15
Kirsten Obernier (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36996147Quantitative determination of lurbinectedin, its unbound fraction and its metabolites in human plasma utilizing ultra-performance LC-MS/MS.PLoS One2023
37397388A model-based head-to-head comparison of single-agent lurbinectedin in the pivotal ATLANTIS Study.Front Oncol2023
34739582Integrated exposure-response analysis of efficacy and safety of lurbinectedin to support the dose regimen in small-cell lung cancer.Cancer Chemother Pharmacol2022
36029310Anti-cancer drug combinations approved by US FDA from 2011 to 2021: main design features of clinical trials and role of pharmacokinetics.Cancer Chemother Pharmacol2022
35012962Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19.Life Sci Alliance2022
35042701Metabolic Disposition of Lurbinectedin, a Potent Selective Inhibitor of Active Transcription of Protein-Coding Genes, in Nonclinical Species and Patients.Drug Metab Dispos2022
33108504Effect of lurbinectedin on the QTc interval in patients with advanced solid tumors: an exposure-response analysis.Cancer Chemother Pharmacol2021
33914350Population Pharmacokinetic-Pharmacodynamic Modeling and Covariate Analyses of Neutropenia and Thrombocytopenia in Patients With Solid Tumors Treated With Lurbinectedin.J Clin Pharmacol2021
34075384Plitidepsin has a positive therapeutic index in adult patients with COVID-19 requiring hospitalization.medRxiv2021
30090974Population-Pharmacokinetic and Covariate Analysis of Lurbinectedin (PM01183), a New RNA Polymerase II Inhibitor, in Pooled Phase I/II Trials in Patients with Cancer.Clin Pharmacokinet2019
28094348Weight of ABCB1 and POR genes on oral tacrolimus exposure in CYP3A5 nonexpressor pediatric patients with stable kidney transplant.Pharmacogenomics J2018
29974200Metabolite profiling of the novel anti-cancer agent, plitidepsin, in urine and faeces in cancer patients after administration of <sup>14</sup>C-plitidepsin.Cancer Chemother Pharmacol2018
29883879Development and validation of a liquid chromatography-tandem mass spectrometry assay for the quantification of lurbinectedin in human plasma and urine.J Pharm Biomed Anal2018
30251598Effects of aripiprazole on pupillometric parameters related to pharmacokinetics and pharmacogenetics after single oral administration to healthy subjects.J Psychopharmacol2018
28592191Influence of two variants of CYP450 oxidoreductase on the stable dose of acenocoumarol in a Spanish population.Pharmacogenomics2017
29048184Association of nicotine metabolism and sex with relapse following varenicline and nicotine replacement therapy.Exp Clin Psychopharmacol2017
26977927A New Pharmacogenetic Algorithm to Predict the Most Appropriate Dosage of Acenocoumarol for Stable Anticoagulation in a Mixed Spanish Population.PLoS One2016
24861353Limited sampling strategies for tacrolimus exposure (AUC0-24) prediction after Prograf(®) and Advagraf(®) administration in children and adolescents with liver or kidney transplants.Transpl Int2014
24821595Population pharmacokinetic modelling and evaluation of different dosage regimens for darunavir and ritonavir in HIV-infected individuals.J Antimicrob Chemother2014
23138399Phase 1 study of two inodilators in neonates undergoing cardiovascular surgery.Pediatr Res2013
23427051A preliminary model to avoid the overestimation of sample size in bioequivalence studies.Drug Res (Stuttg)2013
23532479Contribution of genetic background, traditional risk factors, and HIV-related factors to coronary artery disease events in HIV-positive persons.Clin Infect Dis2013
23249875Contribution of CYP2B6 alleles in explaining extreme (S)-methadone plasma levels: a CYP2B6 gene resequencing study.Pharmacogenet Genomics2013
23111422Pharmacogenetics-based population pharmacokinetic analysis of etravirine in HIV-1 infected individuals.Pharmacogenet Genomics2013
22371894Population pharmacokinetic analysis and pharmacogenetics of raltegravir in HIV-positive and healthy individuals.Antimicrob Agents Chemother2012
22911785An acenocoumarol dosing algorithm using clinical and pharmacogenetic data in Spanish patients with thromboembolic disease.PLoS One2012
21288825Association of pharmacogenetic markers with premature discontinuation of first-line anti-HIV therapy: an observational cohort study.J Infect Dis2011
20139798ADME pharmacogenetics: investigation of the pharmacokinetics of the antiretroviral agent lopinavir coformulated with ritonavir.Pharmacogenet Genomics2010
20218903Genetic polymorphisms of CYP1A2, CYP3A4, CYP3A5, pregnane/steroid X receptor and constitutive androstane receptor in 207 healthy Spanish volunteers.Clin Chem Lab Med2010
19225447Pharmacogenetics-based population pharmacokinetic analysis of efavirenz in HIV-1-infected individuals.Clin Pharmacol Ther2009
19238117In vivo analysis of efavirenz metabolism in individuals with impaired CYP2A6 function.Pharmacogenet Genomics2009
18680690[General concepts and study methods in pharmacogenetics].Enferm Infecc Microbiol Clin2008
17559351ADME pathway approach for pharmacogenetic studies of anti-HIV therapy.Pharmacogenomics2007
15761068Effect of opsonophagocytosis mediated by specific antibodies on the co-amoxiclav serum bactericidal activity against Streptococcus pneumoniae after administration of a single oral dose of pharmacokinetically enhanced 2000/125 mg co-amoxiclav to healthy volunteers.J Antimicrob Chemother2005
12698301Outcome trials of COX-2 selective inhibitors: global safety evaluation does not promise benefits.Eur J Clin Pharmacol2003
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Collaborators

Clinical Development
Co-authored papers 12
Vir Biotechnology Inc.
Co-authored papers 10
Lausanne University Hospital, University of Lausanne
Co-authored papers 7
Departamento de Toxicologia y Farmacologia Preclinica
Co-authored papers 6
Hospital Universitario Marques de Valdecilla
Co-authored papers 2
Hospital Universitario HM Monteprincipe, HM Hospitales
Co-authored papers 2
University College London
Co-authored papers 2
University of the Basque Country UPV/EHU
Co-authored papers 2
University of California San Francisco
Co-authored papers 2
IrsiCaixa AIDS Research Institute, Hospital Universitari Germans Trias i Pujol
Co-authored papers 2
Hospital Universitario HM Monteprincipe, HM Hospitales
Co-authored papers 2
The University of Texas MD Anderson Cancer Center
Co-authored papers 2
University of Geneva
Co-authored papers 2
Instituto de Salud Carlos III, Hospital Universitario La Princesa
Co-authored papers 2
Campus Universidad Autonoma de Madrid
Co-authored papers 2
Hospital Germans Trias i Pujol
Co-authored papers 2
Hospital Universitario Quironsalud Madrid
Co-authored papers 2
Hospital Universitario Ramon y Cajal
Co-authored papers 2
Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG)
Co-authored papers 2
Hospital Universitario de Getafe
Co-authored papers 2
Co-authored papers 2
Hospital Universitario de La Princesa
Co-authored papers 2
Universidad Europea
Co-authored papers 2
University of California San Francisco
Co-authored papers 2
University College London
Co-authored papers 2
Clinical R&D
Co-authored papers 2
IrsiCaixa AIDS Research Institute, Hospital Universitari Germans Trias i Pujol
Co-authored papers 2
Campus Universidad Autonoma de Madrid
Co-authored papers 2
Department of Pharmaceutical Sciences, Utrecht University
Co-authored papers 2
Hospital Universitario de Getafe
Co-authored papers 2