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Author Details

Philip Brohawn
MedImmune LLC
2009
40
26
PMIDPaper TitleJournal TitlePublished Year
36040901Interferon gamma expression and mortality in unselected cohorts of urothelial bladder cancer patients.PLoS One2022
33355200A Blood-based Assay for Assessment of Tumor Mutational Burden in First-line Metastatic NSCLC Treatment: Results from the MYSTIC Study.Clin Cancer Res2021
34681945The Pathogenesis, Molecular Mechanisms, and Therapeutic Potential of the Interferon Pathway in Systemic Lupus Erythematosus and Other Autoimmune Diseases.Int J Mol Sci2021
33225631Long-Term Safety and Efficacy of Anifrolumab in Adults With Systemic Lupus Erythematosus: Results of a Phase II Open-Label Extension Study.Arthritis Rheumatol2021
31676670Safety and Efficacy of Durvalumab and Tremelimumab Alone or in Combination in Patients with Advanced Gastric and Gastroesophageal Junction Adenocarcinoma.Clin Cancer Res2020
31851795Trial of Anifrolumab in Active Systemic Lupus Erythematosus.N Engl J Med2020
30778251The transcription factor c-Myb regulates CD8<sup>+</sup> T cell stemness and antitumor immunity.Nat Immunol2019
29716923Interferon Gamma Messenger RNA Signature in Tumor Biopsies Predicts Outcomes in Patients with Non-Small Cell Lung Carcinoma or Urothelial Cancer Treated with Durvalumab.Clin Cancer Res2018
30093454Early Reduction in ctDNA Predicts Survival in Patients with Lung and Bladder Cancer Treated with Durvalumab.Clin Cancer Res2018
29956883Baseline Plasma Cell Gene Signature Predicts Improvement in Systemic Sclerosis Skin Scores Following Treatment With Inebilizumab (MEDI-551) and Correlates With Disease Activity in Systemic Lupus Erythematosus and Chronic Obstructive Pulmonary Disease.Arthritis Rheumatol2018
28000522Targeting the interferon pathway with sifalimumab for the treatment of systemic lupus erythematosus.Immunotherapy2017
28130918Anifrolumab, an Anti-Interferon-α Receptor Monoclonal Antibody, in Moderate-to-Severe Systemic Lupus Erythematosus.Arthritis Rheumatol2017
28982197Distinct and common expression of receptors for inflammatory mediators in vagal nodose versus jugular capsaicin-sensitive/TRPV1-positive neurons detected by low input RNA sequencing.PLoS One2017
28819706Generation of a functional humanized Delta-like ligand 4 transgenic mouse model.Transgenic Res2017
27923825Rational Selection of Syngeneic Preclinical Tumor Models for Immunotherapeutic Drug Discovery.Cancer Immunol Res2017
27093186Genomic Landscape Survey Identifies SRSF1 as a Key Oncodriver in Small Cell Lung Cancer.PLoS Genet2016
26556607In Vivo Therapeutic Success of MicroRNA-155 Antagomir in a Mouse Model of Lupus Alveolar Hemorrhage.Arthritis Rheumatol2016
27798262Autoimmune manifestations in aged mice arise from early-life immune dysregulation.Sci Transl Med2016
27226090Type I IFNs Regulate Inflammation, Vasculopathy, and Fibrosis in Chronic Cutaneous Graft-versus-Host Disease.J Immunol2016
26257170Neutrophils Regulate Humoral Autoimmunity by Restricting Interferon-γ Production via the Generation of Reactive Oxygen Species.Cell Rep2015
28848849CD4+ T-Cell Profiles and Peripheral Blood Ex-Vivo Responses to T-Cell Directed Stimulation Delineate COPD Phenotypes.Chronic Obstr Pulm Dis2015
26653219HERC5 is a prognostic biomarker for post-liver transplant recurrent human hepatocellular carcinoma.J Transl Med2015
26587322A high density of tertiary lymphoid structure B cells in lung tumors is associated with increased CD4<sup>+</sup> T cell receptor repertoire clonality.Oncoimmunology2015
26348576Synergistic actions of blocking angiopoietin-2 and tumor necrosis factor-α in suppressing remodeling of blood vessels and lymphatics in airway inflammation.Am J Pathol2015
23434567A phase 1b clinical trial evaluating sifalimumab, an anti-IFN-α monoclonal antibody, shows target neutralisation of a type I IFN signature in blood of dermatomyositis and polymyositis patients.Ann Rheum Dis2014
25384217Germinal center reentries of BCL2-overexpressing B cells drive follicular lymphoma progression.J Clin Invest2014
24757153Inhibition of myogenic microRNAs 1, 133, and 206 by inflammatory cytokines links inflammation and muscle degeneration in adult inflammatory myopathies.Arthritis Rheumatol2014
24571613Increased IR-A/IR-B ratio in non-small cell lung cancers associates with lower epithelial-mesenchymal transition signature and longer survival in squamous cell lung carcinoma.BMC Cancer2014
24289491MicroRNA-206 induces G1 arrest in melanoma by inhibition of CDK4 and Cyclin D.Pigment Cell Melanoma Res2014
24431284The plasma cell signature in autoimmune disease.Arthritis Rheumatol2014
23990866Circulating tumor cells: application as a biomarker for molecular characterization and predictor of survival in an all-comer solid tumor phase I clinical study.PLoS One2013
24200637Low frequency KRAS mutations in colorectal cancer patients and the presence of multiple mutations in oncogenic drivers in non-small cell lung cancer patients.Cancer Genet2013
21881594Relationship between disease activity and type 1 interferon- and other cytokine-inducible gene expression in blood in dermatomyositis and polymyositis.Genes Immun2012
22574157The CEA/CD3-bispecific antibody MEDI-565 (MT111) binds a nonlinear epitope in the full-length but not a short splice variant of CEA.PLoS One2012
22262795Opposing roles of membrane and soluble forms of the receptor for advanced glycation end products in primary respiratory syncytial virus infection.J Infect Dis2012
21860416A novel oncogenic role for the miRNA-506-514 cluster in initiating melanocyte transformation and promoting melanoma growth.Oncogene2012
21803750Patients with systemic lupus erythematosus, myositis, rheumatoid arthritis and scleroderma share activation of a common type I interferon pathway.Ann Rheum Dis2011
22046260Altered expression of insulin receptor isoforms in breast cancer.PLoS One2011
19479852Neutralization of interferon-alpha/beta-inducible genes and downstream effect in a phase I trial of an anti-interferon-alpha monoclonal antibody in systemic lupus erythematosus.Arthritis Rheum2009
20948567Development of Potential Pharmacodynamic and Diagnostic Markers for Anti-IFN-α Monoclonal Antibody Trials in Systemic Lupus Erythematosus.Hum Genomics Proteomics2009
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Collaborators

Translational and Clinical Data Sciences
Co-authored papers 24
Oncology R&D Unit
Co-authored papers 22
Cellular Biomedicine Group Inc.
Co-authored papers 20
Georgia Cancer Center, Medical College of Georgia
Co-authored papers 13
MedImmune LLC
Co-authored papers 12
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Co-authored papers 5
Corbus Pharmaceuticals Holdings
Co-authored papers 4
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Co-authored papers 4
Brigham Women's Hospital, Harvard Medical School
Co-authored papers 3
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Co-authored papers 2
Samsung Medical Center, Sungkyunkwan University School of Medicine
Co-authored papers 1
National Cancer Institute, National Institutes of Health (NIH)
Co-authored papers 1
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Center for Cancer Research, National Cancer Institute, National Institutes of Health
Co-authored papers 1
Co-authored papers 1
Sheffield Institute of Translational Neuroscience, University of Sheffield
Co-authored papers 1
Brigham and Women's Hospital, Harvard Medical School
Co-authored papers 1
Center for Cancer Research, National Cancer Institute, National Institutes of Health
Co-authored papers 1
Bristol-Myers Squibb Co.
Co-authored papers 1
National Cancer Institute, National Institutes of Health
Co-authored papers 1
US Department of Veterans Affairs Medical Center
Co-authored papers 1
VA Boston Healthcare System
Co-authored papers 1
Hubei Engineering Research Center for Bio-enzyme Catalysis, Hubei University
Co-authored papers 1
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Center for Cancer Research, National Cancer Institute, National Institutes of Health
Co-authored papers 1
Boston Children's Hospital, Seoul National University, Seoul National University Hospital
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