Author details

Full Name

Nathalie Y R Agar

Affiliation

ORCID

Career Start Year

2002

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37546759	Spatially resolved metabolomics and isotope tracing reveal dynamic metabolic responses of dentate granule neurons with acute stimulation.		2023
37929637	The dentate gyrus differentially metabolizes glucose and alternative fuels during rest and stimulation.		2023
37584601	Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways.	Cancer Discov	2023
37798473	Spatially resolved metabolomics and isotope tracing reveal dynamic metabolic responses of dentate granule neurons with acute stimulation.		2023
37961582	Rewiring of cortical glucose metabolism fuels human brain cancer growth.		2023
37469028	Chemical QuantArray: A Quantitative Tool for Mass Spectrometry Imaging.		2023
37324218	WSD-0922, a novel brain-penetrant inhibitor of epidermal growth factor receptor, promotes survival in glioblastoma mouse models.		2023
36625762	Deep Learning on Multimodal Chemical and Whole Slide Imaging Data for Predicting Prostate Cancer Directly from Tissue Images.		2023
34383057	Multimodal platform for assessing drug distribution and response in clinical trials.	Neuro Oncol	2022
35973991	Single cell spatial analysis reveals the topology of immunomodulatory purinergic signaling in glioblastoma.	Nat Commun	2022
35463966	Multiplatform Metabolomics Studies of Human Cancers With NMR and Mass Spectrometry Imaging.	Front Mol Biosci	2022
36243020	Chronic convection-enhanced delivery of topotecan for patients with recurrent glioblastoma: a first-in-patient, single-centre, single-arm, phase 1b trial.	Lancet Oncology, The	2022
36305736	BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma.	Cancer Discov	2022
36173860	Oncometabolite d-2HG alters T cell metabolism to impair CD8<sup>+</sup> T cell function.	Science	2022
36031342	Sustained Supratherapeutic Paclitaxel Delivery Enhances Irreversible Sarcoma Cell Death.	Molecular Cancer Therapeutics	2022
36223740	PARP-inhibition reprograms macrophages toward an anti-tumor phenotype.	Cell Rep	2022
36071925	Convection enhanced delivery of EGFR targeting antibody-drug conjugates Serclutamab talirine and Depatux-M in glioblastoma patient-derived xenografts.	Neuro-Oncology Advances	2022
35486732	Overcoming differential tumor penetration of BRAF inhibitors using computationally guided combination therapy.	Science advances	2022
36067168	Spatially resolved characterization of tissue metabolic compartments in fasted and high-fat diet livers.	PLoS ONE	2022
35985343	De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma.	Cancer Cell	2022
35314684	A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine.	Nat Commun	2022
35040929	massNet: integrated processing and classification of spatially resolved mass spectrometry data using deep learning for rapid tumor delineation.	Bioinformatics	2022
34545087	Peak learning of mass spectrometry imaging data using artificial neural networks.	Nat Commun	2021
34020766	Bringing Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging to the Clinics.	Clinics in Laboratory Medicine	2021
34236164	High-Throughput Analysis of Tissue-Embedded Single Cells by Mass Spectrometry with Bimodal Imaging and Object Recognition.	Analytical Chemistry	2021
33905245	Î²-Cyclodextrin-poly (Î²-Amino Ester) Nanoparticles Are a Generalizable Strategy for High Loading and Sustained Release of HDAC Inhibitors.	ACS applied materials & interfaces	2021
34050676	Heterogeneous delivery across the blood-brain barrier limits the efficacy of an EGFR-targeting antibody drug conjugate in glioblastoma.	Neuro Oncol	2021
33619381	A unique subset of glycolytic tumour-propagating cells drives squamous cell carcinoma.	Nat Metab	2021
33315366	Spatial Distribution of Transcytosis Relevant Phospholipids in Response to Omega-3 Dietary Deprivation.	ACS Chem Biol	2021
34504095	Interim clinical trial analysis of intraoperative mass spectrometry for breast cancer surgery.	npj Breast Cancer	2021
32663458	PHD3 Loss Promotes Exercise Capacity and Fat Oxidation in Skeletal Muscle.	Cell Metab	2020
31746669	Dysregulation of very-long-chain fatty acid metabolism causes membrane saturation and induction of the unfolded protein response.	Mol Biol Cell	2020
31767628	Localized Metabolomic Gradients in Patient-Derived Xenograft Models of Glioblastoma.	Cancer Res	2020
31558424	Pre- and Postoperative Neratinib for HER2-Positive Breast Cancer Brain Metastases: Translational Breast Cancer Research Consortium 022.	Clin Breast Cancer	2020
30932478	Automatic 3D Nonlinear Registration of Mass Spectrometry Imaging and Magnetic Resonance Imaging Data.	Anal Chem	2019
31286061	Rapid MALDI mass spectrometry imaging for surgical pathology.	npj Precision Oncology	2019
31025851	Metal Oxide Laser Ionization Mass Spectrometry Imaging (MOLI MSI) Using Cerium(IV) Oxide.	Analytical Chemistry	2019
30745465	Molecular Characterization of Prostate Cancer with Associated Gleason Score Using Mass Spectrometry Imaging.	Mol Cancer Res	2019
31111916	A large-scale drug screen identifies selective inhibitors of class I HDACs as a potential therapeutic option for SHH medulloblastoma.	Neuro Oncol	2019
30839199	Genetically Encoded Fluorescent Proteins Enable High-Throughput Assignment of Cell Cohorts Directly from MALDI-MS Images.	Anal Chem	2019
31245380	Quantitative Wide-Field Imaging Techniques for Fluorescence Guided Neurosurgery.	Front Surg	2019
29209003	Prostate cancer diagnosis and characterization with mass spectrometry imaging.	Prostate Cancer and Prostatic Diseases	2018
29016900	Is the blood-brain barrier really disrupted in all glioblastomas? A critical assessment of existing clinical data.	Neuro Oncol	2018
29970480	Efficacy of the MDM2 Inhibitor SAR405838 in Glioblastoma Is Limited by Poor Distribution Across the Blood-Brain Barrier.	Mol Cancer Ther	2018
30382243	Blood-brain-barrier organoids for investigating the permeability of CNS therapeutics.		2018
30128689	Rapid discrimination of pediatric brain tumors by mass spectrometry imaging.	J Neurooncol	2018
30464169	Integrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma.	Nat Commun	2018
29480977	Unique Intradural Inflammatory Mass Containing Precipitated Morphine: Confirmatory Analysis by LESA-MS and MALDI-MS.	Pain Practice	2018
29608279	In Vitro Liquid Extraction Surface Analysis Mass Spectrometry (ivLESA-MS) for Direct Metabolic Analysis of Adherent Cells in Culture.	Anal Chem	2018
28082416	A brain-penetrant RAF dimer antagonist for the noncanonical BRAF oncoprotein of pediatric low-grade astrocytomas.	Neuro Oncol	2017