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Author Details

Stephen J Kanes
University of North Carolina School of Medicine
1993
63
34
PMIDPaper TitleJournal TitlePublished Year
36191643Effect of brexanolone on depressive symptoms, anxiety, and insomnia in women with postpartum depression: Pooled analyses from 3 double-blind, randomized, placebo-controlled clinical trials in the HUMMINGBIRD clinical program.J Affect Disord2023
37077711Targeting the Arginine Vasopressin V<sub>1b</sub> Receptor System and Stress Response in Depression and Other Neuropsychiatric Disorders.Neuropsychiatr Dis Treat2023
37132201Zuranolone for the Treatment of Adults With Major Depressive Disorder: A Randomized, Placebo-Controlled Phase 3 Trial.Am J Psychiatry2023
36724109Effect of Zuranolone on Concurrent Anxiety and Insomnia Symptoms in Women With Postpartum Depression.J Clin Psychiatry2023
36811520Zuranolone in Major Depressive Disorder: Results From MOUNTAIN-A Phase 3, Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial.J Clin Psychiatry2023
34352138A phase 1 double-blind, placebo-controlled study of zuranolone (SAGE-217) in a phase advance model of insomnia in healthy adults.Hum Psychopharmacol2022
35378149Patient-reported health-related quality of life from a randomized, placebo-controlled phase 2 trial of zuranolone in adults with major depressive disorder.J Affect Disord2022
33387701Zuranolone as an oral adjunct to treatment of Parkinsonian tremor: A phase 2, open-label study.J Neurol Sci2021
33719782Achieving clinical response in postpartum depression leads to improvement in health-related quality of life.Curr Med Res Opin2021
34154385Comment on "Understanding the Clinical Effects and Mechanisms of Action of Neurosteroids".Am J Psychiatry2021
34190962Effect of Zuranolone vs Placebo in Postpartum Depression: A Randomized Clinical Trial.JAMA Psychiatry2021
33181049Brexanolone in Postpartum Depression: <i>Post Hoc</i> Analyses to Help Inform Clinical Decision-Making.J Womens Health (Larchmt)2021
31338688SAGE-217, A Novel GABA<sub>A</sub> Receptor Positive Allosteric Modulator: Clinical Pharmacology and Tolerability in Randomized Phase I Dose-Finding Studies.Clin Pharmacokinet2020
32666402Associations between commonly used patient-reported outcome tools in postpartum depression clinical practice and the Hamilton Rating Scale for Depression.Arch Womens Ment Health2020
32435663Allopregnanolone in postpartum depression: Role in pathophysiology and treatment.Neurobiol Stress2020
31255299Brexanolone injection for post-partum depression treatment - Authors' reply.Lancet2019
31774969Trial of SAGE-217 in Patients with Major Depressive Disorder. Reply.N Engl J Med2019
30177236Brexanolone injection in post-partum depression: two multicentre, double-blind, randomised, placebo-controlled, phase 3 trials.Lancet2018
27556834Burden of illness for super-refractory status epilepticus patients.J Med Econ2017
28370307Open-label, proof-of-concept study of brexanolone in the treatment of severe postpartum depression.Hum Psychopharmacol2017
28779545Brexanolone as adjunctive therapy in super-refractory status epilepticus.Ann Neurol2017
28619476Brexanolone (SAGE-547 injection) in post-partum depression: a randomised controlled trial.Lancet2017
26111262First Human Study of the Investigational Sedative and Anesthetic Drug AZD3043: A Dose-Escalation Trial to Assess the Safety, Pharmacokinetics, and Efficacy of a 30-Minute Infusion in Healthy Male Volunteers.Anesth Analg2015
26097986A Bolus and Bolus Followed by Infusion Study of AZD3043, an Investigational Intravenous Drug for Sedation and Anesthesia: Safety and Pharmacodynamics in Healthy Male and Female Volunteers.Anesth Analg2015
24525659The selective neurokinin 3 antagonist AZD2624 does not improve symptoms or cognition in schizophrenia: a proof-of-principle study.J Clin Psychopharmacol2014
25363147Pediatric super-refractory status epilepticus treated with allopregnanolone.Ann Neurol2014
23430984A PET study with [11C]AZ10419369 to determine brain 5-HT1B receptor occupancy of zolmitriptan in healthy male volunteers.Cephalalgia2013
22391030Glutamate-based depression GBD.Med Hypotheses2012
22955840Association of schizophrenia with the phenylthiocarbamide taste receptor haplotype on chromosome 7q.Psychiatr Genet2012
19030002Developmental etiology for neuroanatomical and cognitive deficits in mice overexpressing Galphas, a G-protein subunit genetically linked to schizophrenia.Mol Psychiatry2009
18230676Constitutive activation of the G-protein subunit Galphas within forebrain neurons causes PKA-dependent alterations in fear conditioning and cortical Arc mRNA expression.Learn Mem2008
16738544Constitutive activation of Galphas within forebrain neurons causes deficits in sensorimotor gating because of PKA-dependent decreases in cAMP.Neuropsychopharmacology2007
17329469Visual attention circuitry in schizophrenia investigated with oddball event-related functional magnetic resonance imaging.Am J Psychiatry2007
17475741Neurocognitive endophenotypes in a multiplex multigenerational family study of schizophrenia.Am J Psychiatry2007
17081698Rolipram: a specific phosphodiesterase 4 inhibitor with potential antipsychotic activity.Neuroscience2007
17119931Pharmacokinetic and behavioral characterization of a long-term antipsychotic delivery system in rodents and rabbits.Psychopharmacology (Berl)2007
17208411Phenylthiocarbamide (PTC) perception in patients with schizophrenia and first-degree family members: relationship to clinical symptomatology and psychophysical olfactory performance.Schizophr Res2007
16123740Corticosterone modulates auditory gating in mouse.Neuropsychopharmacology2006
17050269Olfactory functioning in schizophrenia: relationship to clinical, neuropsychological, and volumetric MRI measures.J Clin Exp Neuropsychol2006
16750890Mice expressing constitutively active Gsalpha exhibit stimulus encoding deficits similar to those observed in schizophrenia patients.Neuroscience2006
16513864Prognostic variables at intake and long-term level of function in schizophrenia.Am J Psychiatry2006
16192313Ketamine produces lasting disruptions in encoding of sensory stimuli.J Pharmacol Exp Ther2006
15800154Phenylthiocarbamide perception in patients with schizophrenia and first-degree family members.Am J Psychiatry2005
16199830Levels-of-processing effect on frontotemporal function in schizophrenia during word encoding and recognition.Am J Psychiatry2005
15908134Monoamine reuptake inhibition and nicotine receptor antagonism reduce amplitude and gating of auditory evoked potentials.Neuroscience2005
15093687Altered RNA editing of serotonin 5-HT2C receptor induced by interferon: implications for depression associated with cytokine therapy.Brain Res Mol Brain Res2004
15176475The effects of ketamine vary among inbred mouse strains and mimic schizophrenia for the P80, but not P20 or N40 auditory ERP components.Neurochem Res2004
15489033Phosphodiesterase inhibitors: a novel mechanism for receptor-independent antipsychotic medications.Neuroscience2004
14970826Patient attitudes towards surgically implantable, long-term delivery of psychiatric medicine.Neuropsychopharmacology2004
14735128Effects of chronic olanzapine and haloperidol differ on the mouse N1 auditory evoked potential.Neuropsychopharmacology2004
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Collaborators

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AstraZeneca Pharmaceuticals
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State University of New York at Stony Brook.
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Seattle Children's Hospital, University of Washington
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Massachusetts General Hospital
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University of California davis
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Columbia University
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National Institute of Mental Health
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Cincinnati Children's Hospital Medical Center
Co-authored papers 1
Beth Israel Deaconess Medical Center, Division of Neurocritical Care and Emergency Neurology, Division of Clinical Neurophysiology, Massachusetts General Hospital, Boston, MA, Harvard Medical School, Massachusetts General Hospital, Massachusetts General Hospital Fellowship in Epilepsy and Clinical Neurophysiology, Massachusetts General Hospital, Brigham and Women's Hospital, Harvard Medical School Fellowship Training Program in Neurocritical Care, Massachusetts General Hospital, Brigham and Women's Hospital, Harvard Medical School Partners Neurology Residency Training Program, Yale College
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University of California
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Duke University School of Medicine, USA Veterans Affairs Medical Center
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Children's Memorial Hospital and Northwestern University Feinberg School of Medicine
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Saint Joseph's University
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Brigham and Women's Hospital
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