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Author Details

Gerald T Nepom
Wash Benaroya Research Institute at Virginia Mason
1975
321
73
PMIDPaper TitleJournal TitlePublished Year
36223848Effects of combination treatment with tezepelumab and allergen immunotherapy on nasal responses to allergen: A randomized controlled trial.J Allergy Clin Immunol2023
37751304Islet-autoreactive CD4+ T cells are linked with response to alefacept in type 1 diabetes.JCI Insight2023
37003475Distinct trajectories distinguish antigen-specific T cells in peanut-allergic individuals undergoing oral immunotherapy.J Allergy Clin Immunol2023
36521801Omics-oriented research illustrated with the LEAP study and the OASIS bioinformatics tool.J Allergy Clin Immunol2023
36403663Epidermal differentiation complex genetic variation in atopic dermatitis and peanut allergy.J Allergy Clin Immunol2023
36909599FOXP3[+] regulatory T cells use heparanase to access IL-2 bound to ECM in inflamed tissues.bioRxiv2023
36732171Incorporating genetics in identifying peanut allergy risk and tailoring allergen immunotherapy: A perspective on the genetic findings from the LEAP trial.J Allergy Clin Immunol2023
34981778HLA alleles and sustained peanut consumption promote IgG4 responses in subjects protected from peanut allergy.J Clin Invest2022
36466872HLA-associated outcomes in peanut oral immunotherapy trials identify mechanistic and clinical determinants of therapeutic success.Front Immunol2022
36119087Synergistic targeting of immunologic pathways to empower durable tolerance therapies.Front Immunol2022
36282595IL-6-targeted therapies to block the cytokine or its receptor drive distinct alterations in T cell function.JCI Insight2022
33351781Exhausted-like CD8+ T cell phenotypes linked to C-peptide preservation in alefacept-treated T1D subjects.JCI Insight2021
33741606Uncovering Pathways to Personalized Therapies in Type 1 Diabetes.Diabetes2021
33819508Differential induction of allergen-specific IgA responses following timothy grass subcutaneous and sublingual immunotherapy.J Allergy Clin Immunol2021
34616405Approaches to Establishing Tolerance in Immune Mediated Diseases.Front Immunol2021
34806648Autoreactive T cell receptors with shared germline-like α chains in type 1 diabetes.JCI Insight2021
32231298Beta cell-specific CD8<sup>+</sup> T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes.Nat Immunol2020
31815738Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression.J Clin Invest2020
30683697Abatacept Targets T Follicular Helper and Regulatory T Cells, Disrupting Molecular Pathways That Regulate Their Proliferation and Maintenance.J Immunol2019
31671072A composite immune signature parallels disease progression across T1D subjects.JCI Insight2019
31457096Discriminative T cell recognition of cross-reactive islet-antigens is associated with HLA-DQ8 transdimer-mediated autoimmune diabetes.Sci Adv2019
30825465The MALT1 locus and peanut avoidance in the risk for peanut allergy.J Allergy Clin Immunol2019
29128670Synchronous immune alterations mirror clinical response during allergen immunotherapy.J Allergy Clin Immunol2018
27785529Rebranding asymptomatic type 1 diabetes: the case for autoimmune beta cell disorder as a pathological and diagnostic entity.Diabetologia2017
28467868Academic, Foundation, and Industry Collaboration in Finding New Therapies.N Engl J Med2017
28754194Looking behind the data curtain.Cell Immunol2017
28566371Single-Cell RNA Sequencing Reveals Expanded Clones of Islet Antigen-Reactive CD4<sup>+</sup> T Cells in Peripheral Blood of Subjects with Type 1 Diabetes.J Immunol2017
28844471Remodeling T cell compartments during anti-CD3 immunotherapy of type 1 diabetes.Cell Immunol2017
28550202Antigen-Specific T Cell Analysis Reveals That Active Immune Responses to β Cell Antigens Are Focused on a Unique Set of Epitopes.J Immunol2017
26948997Obstacles and opportunities for targeting the effector T cell response in type 1 diabetes.J Autoimmun2016
28664195Partial exhaustion of CD8 T cells and clinical response to teplizumab in new-onset type 1 diabetes.Sci Immunol2016
27124592Genetically modified human CD4(+) T cells can be evaluated in vivo without lethal graft-versus-host disease.Immunology2016
27474121Clinical trial data access: Opening doors with TrialShare.J Allergy Clin Immunol2016
27141097A Contra Capture Protein Array Platform for Studying Post-translationally Modified (PTM) Auto-antigenomes.Mol Cell Proteomics2016
27209482Correlation Among Hypoglycemia, Glycemic Variability, and C-Peptide Preservation After Alefacept Therapy in Patients with Type 1 Diabetes Mellitus: Analysis of Data from the Immune Tolerance Network T1DAL Trial.Clin Ther2016
26718498A Preclinical Consortium Approach for Assessing the Efficacy of Combined Anti-CD3 Plus IL-1 Blockade in Reversing New-Onset Autoimmune Diabetes in NOD Mice.Diabetes2016
25972006Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis.Sci Transl Med2015
26341315Adult-onset type 1 diabetes patients display decreased IGRP-specific Tr1 cells in blood.Clin Immunol2015
26122171Biomarkers for antigen immunotherapy in allergy and type 1 diabetes.Clin Immunol2015
26193635Alefacept provides sustained clinical and immunological effects in new-onset type 1 diabetes patients.J Clin Invest2015
24430436Low HERV-K(C4) copy number is associated with type 1 diabetes.Diabetes2014
24795433Restoring the balance: immunotherapeutic combinations for autoimmune disease.Dis Model Mech2014
24844227Avidity-dependent programming of autoreactive T cells in T1D.PLoS One2014
23574315Immunological biomarkers: catalysts for translational advances in autoimmune diabetes.Clin Exp Immunol2013
24622414Targeting of memory T cells with alefacept in new-onset type 1 diabetes (T1DAL study): 12 month results of a randomised, double-blind, placebo-controlled phase 2 trial.Lancet Diabetes Endocrinol2013
24090977Antigen-specific immunomodulation for type 1 diabetes by novel recombinant antibodies directed against diabetes-associates auto-reactive T cell epitope.J Autoimmun2013
23971054IL-10 induction from implants delivering pancreatic islets and hyaluronan.J Diabetes Res2013
23601689Systems scale interactive exploration reveals quantitative and qualitative differences in response to influenza and pneumococcal vaccines.Immunity2013
23405091Transient B-cell depletion with anti-CD20 in combination with proinsulin DNA vaccine or oral insulin: immunologic effects and efficacy in NOD mice.PLoS One2013
23510726Anti-cytokine therapies in T1D: Concepts and strategies.Clin Immunol2013
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Collaborators

William W Kwok
Center for Translational Immunology, Benaroya Research Institute at Virginia Mason
Co-authored papers 61
Jane H Buckner
Center for Translational Immunology, Benaroya Research Institute at Virginia Mason
Co-authored papers 21
Helena Reijonen
City of Hope Medical Center, Beckman Research Institute
Co-authored papers 21
Carla J Greenbaum
Center for Interventional Immunology, Benaroya Research Institute at Virginia Mason
Co-authored papers 19
Vivian H Gersuk
Center for Systems Immunology, Benaroya Research Institute
Co-authored papers 18
Susan L Holbeck
National Cancer Institute
Co-authored papers 12
Cate Speake
Center for Interventional Immunology, Benaroya Research Institute at Virginia Mason
Co-authored papers 10
Sarah Alice Long
Center for Translational Immunology, Benaroya Research Institute at Virginia Mason
Co-authored papers 10
Mario R Ehlers
Clinical Trials Group
Co-authored papers 10
Peter S Linsley
8Benaroya Research Institute
Co-authored papers 8
Kristina M Harris
University of California san francisco
Co-authored papers 6
Karen Cerosaletti
Center for Translational Immunology
Co-authored papers 6
Elisavet Serti
The Henry Jackson Foundation.
Co-authored papers 5
Hannah A DeBerg
Benaroya Research Institute at Virginia Mason
Co-authored papers 5
Kevan C Herold
Yale University
Co-authored papers 5
Ronald N Germain
National Institute of Allergy and Infectious Diseases, National Institutes of Health
Co-authored papers 5
Henry A Erlich
Children's Hospital Oakland Research Institute
Co-authored papers 5
Mario G Rosasco
Center for Systems Immunology, Benaroya Research Institute
Co-authored papers 5
Erik Wambre
Precision Immunology Institute, Icahn School of Medicine at Mount Sinai
Co-authored papers 4
Junbao Yang
Benaroya Research Institute
Co-authored papers 4
Matthew J Dufort
Center for Systems Immunology, Benaroya Research Institute Seattle
Co-authored papers 4
Ingo Ruczinski
Co-authored papers 4
Noha Lim
Co-authored papers 3
Damien Chaussabel
Co-authored papers 3
Peter K Gregersen
Co-authored papers 3
Jerill Thorpe
Benaroya Research Institute at Virginia Mason
Co-authored papers 3
David A Hafler
Yale School of Medicine, Yale School of Public Health
Co-authored papers 3
Elisa Balmas
Center for Translational Immunology
Co-authored papers 3
Alkis Togias
National Institute of Allergy and Infectious Diseases, National Institutes of Health
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Release 1.2