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Author Details

Angela Tam
2007
46
30
PMIDPaper TitleJournal TitlePublished Year
37380628A landscape of response to drug combinations in non-small cell lung cancer.Nat Commun2023
33879555PCA062, a P-cadherin Targeting Antibody-Drug Conjugate, Displays Potent Antitumor Activity Against P-cadherin-expressing Malignancies.Mol Cancer Ther2021
32677466Epigenomic programming in early fetal brain development.Epigenomics2020
30674502Capmatinib (INC280) Is Active Against Models of Non-Small Cell Lung Cancer and Other Cancer Types with Defined Mechanisms of MET Activation.Clinical Cancer Research2019
30208970Differential responses of MET activations to MET kinase inhibitor and neutralizing antibody.Journal of Translational Medicine2018
29232880The Genome of the Northern Sea Otter (Enhydra lutris kenyoni).Genes (Basel)2017
28808080Characterization of the human thyroid epigenome.J Endocrinol2017
28539475The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation.Sci Transl Med2017
28394352Spatial heterogeneity in medulloblastoma.Nat Genet2017
29232881The Genome of the Beluga Whale (Delphinapterus leucas).Genes (Basel)2017
27659046High-Order Drug Combinations Are Required to Effectively Kill Colorectal Cancer Cells.Cancer Res2016
26760213Divergent clonal selection dominates medulloblastoma at recurrence.Nature2016
27011106Separable Roles for a Caenorhabditis elegans RMI1 Homolog in Promoting and Antagonizing Meiotic Crossovers Ensure Faithful Chromosome Inheritance.PLoS Biology2016
26536169Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma.N Engl J Med2016
26061751Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.N Engl J Med2015
25873175AXL mediates resistance to PI3Kα inhibition by activating the EGFR/PKC/mTOR axis in head and neck and esophageal squamous cell carcinomas.Cancer Cell2015
25693563Integrative analysis of 111 reference human epigenomes.Nature2015
25690954Epigenetic and transcriptional determinants of the human breast.Nat Commun2015
25673643FGFR-Mediated Reactivation of MAPK Signaling Attenuates Antitumor Effects of Imatinib in Gastrointestinal Stromal Tumors.Cancer Discovery2015
25053665DNA helicase HIM-6/BLM both promotes MutSγ-dependent crossovers and antagonizes MutSγ-independent interhomolog associations during caenorhabditis elegans meiosis.Genetics2014
24633789A Notch-dependent transcriptional hierarchy promotes mesenchymal transdifferentiation in the cardiac cushion.Dev Dyn2014
23708189DNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscape.Nat Genet2013
23941359Barnacle: detecting and characterizing tandem duplications and fusions in transcriptome assemblies.BMC Genomics2013
23812591Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells.Nature2013
23804400Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm.Genome Res2013
23634996Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia.N Engl J Med2013
23616356Complete genomic landscape of a recurring sporadic parathyroid carcinoma.J Pathol2013
23334666The genetic landscape of high-risk neuroblastoma.Nat Genet2013
22495314The clonal and mutational evolution spectrum of primary triple-negative breast cancers.Nature2012
21796119Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma.Nature2011
21429165SNP discovery in black cottonwood (Populus trichocarpa) by population transcriptome resequencing.Mol Ecol Resour2011
20551221Locus co-occupancy, nucleosome positioning, and H3K4me1 regulate the functionality of FOXA2-, HNF4A-, and PDX1-bound loci in islets and liver.Genome Res2010
20696054Evolution of an adenocarcinoma in response to selection by targeted kinase inhibitors.Genome Biol2010
20942669ARID1A mutations in endometriosis-associated ovarian carcinomas.N Engl J Med2010
20935650De novo assembly and analysis of RNA-seq data.Nat Methods2010
20686952Preparation and analysis of microRNA libraries using the Illumina massively parallel sequencing technology.Methods Mol Biol2010
20215515A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.Cancer Res2010
20081860Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin.Nat Genet2010
20373513Digital gene expression by tag sequencing on the illumina genome analyzer.Curr Protoc Hum Genet2010
19196724Histone H3.3 incorporation provides a unique and functionally essential telomeric chromatin in embryonic stem cells.Genome Research2009
19366796Ligand-dependent platelet-derived growth factor receptor (PDGFR)-alpha activation sensitizes rare lung cancer and sarcoma cells to PDGFR kinase inhibitors.Cancer Res2009
18787082Genome-wide relationship between histone H3 lysine 4 mono- and tri-methylation and transcription factor binding.Genome Res2008
18186943Cerebrospinal fluid matrix metalloproteinase-9 increases during treatment of recurrent malignant gliomas.2008
18077425Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling.Proc Natl Acad Sci U S A2007
17135571Large-scale production of SAGE libraries from microdissected tissues, flow-sorted cells, and cell lines.Genome Res2007
17324339Matrix metalloprotease-9 in cerebrospinal fluid correlates with disease activity in lymphomatous meningitis.2007
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