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Author Details

Andrew M Chan
1986
88
41
PMIDPaper TitleJournal TitlePublished Year
37185447Neuropathological signatures revealed by transcriptomic and proteomic analysis in Pten-deficient mouse models.2023
36495259Curaxin CBL0137 inhibits endothelial inflammation and atherogenesis via suppression of the Src-YAP signalling axis.2023
36585695Inhibition of PI3 kinase isoform p110α suppresses neuroblastoma growth and induces the reduction of Anaplastic Lymphoma Kinase.2022
35526071Endothelial nitric oxide synthase (eNOS)-NO signaling axis functions to promote the growth of prostate cancer stem-like cells.Stem Cell Res Ther2022
36116740The mitotic regulator RCC2 promotes glucose metabolism through BACH1-dependent transcriptional upregulation of hexokinase II in glioma.Cancer Lett2022
36408158Functional analysis of the short splicing variant encoded by CHI3L1/YKL-40 in glioblastoma.Frontiers in Oncology2022
33428810SLC6A20 transporter: a novel regulator of brain glycine homeostasis and NMDAR function.EMBO Molecular Medicine2021
33932101Tumour-derived substrate-adherent cells promote neuroblastoma survival through secreted trophic factors.Molecular Oncology2021
31240311PTEN Activity Defines an Axis for Plasticity at Cortico-Amygdala Synapses and Influences Social Behavior.Cereb Cortex2020
31560052Corrigendum to: -PTEN activity defines an axis for plasticity at cortico-amygdala synapses and influences social behavior.Cereb Cortex2020
32150788Autism-associated PTEN missense mutation leads to enhanced nuclear localization and neurite outgrowth in an induced pluripotent stem cell line.2020
30797170Fresh evidence for major brain gangliosides as a target for the treatment of Alzheimer's disease.Neurobiology of Aging2019
31454965Multifaceted Regulation of PTEN Subcellular Distributions and Biological Functions.Cancers2019
29772266PTEN PDZ-binding domain suppresses mammary carcinogenesis in the MMTV-PyMT breast cancer model.Cancer Letters2018
30593266Homology-independent multiallelic disruption via CRISPR/Cas9-based knock-in yields distinct functional outcomes in human cells.BMC Biology2018
29992318Loss of tumor suppressor IGFBP4 drives epigenetic reprogramming in hepatic carcinogenesis.Nucleic Acids Research2018
29608813Identification of a PTEN mutation with reduced protein stability, phosphatase activity, and nuclear localization in Hong Kong patients with autistic features, neurodevelopmental delays, and macrocephaly.Autism Research2018
29729901Differential regulation of the pro-inflammatory biomarker, YKL-40/CHI3L1, by PTEN/Phosphoinositide 3-kinase and JAK2/STAT3 pathways in glioblastoma.Cancer Lett2018
28610953A thirty-year quest for a role of R-Ras in cancer: from an oncogene to a multitasking GTPase.Cancer Letters2017
28669564Eriocalyxin B, a novel autophagy inducer, exerts anti-tumor activity through the suppression of Akt/mTOR/p70S6K signaling pathway in breast cancer.Biochem Pharmacol2017
27707879MAGI-1 Interacts with Nephrin to Maintain Slit Diaphragm Structure through Enhanced Rap1 Activation in Podocytes.J Biol Chem2016
26747049Erratum to: Separation and Characterization of Epithelial and Mesenchymal-like Murine Mammary Tumor Cells Reveals Epithelial Cell Differentiation Plasticity and Enhanced Tumorigenicity of Epithelial-enriched Tumor Cells.Cancer Microenvironment2016
26780512PTEN recruitment controls synaptic and cognitive function in Alzheimer's models.Nat Neurosci2016
26710069R-Ras Regulates Murine T Cell Migration and Intercellular Adhesion Molecule-1 Binding.PLoS ONE2015
25500144A CCRK-EZH2 epigenetic circuitry drives hepatocarcinogenesis and associates with tumor recurrence and poor survival of patients.Journal of Hepatology2015
26004418The genetic landscapes of inflammation-driven gastrointestinal tract cancers.Current Pharmaceutical Design2015
24771856An increase in tolerogenic dendritic cell and natural regulatory T cell numbers during experimental autoimmune encephalomyelitis in Rras-/- mice results in attenuated disease.Journal of Immunology2014
24469813Genetic dissection of plexin signaling in vivo.Proceedings of the National Academy of Sciences of the United States of America2014
22237886Separation and Characterization of Epithelial and Mesenchymal-like Murine Mammary Tumor Cells Reveals Epithelial Cell Differentiation Plasticity and Enhanced Tumorigenicity of Epithelial-enriched Tumor Cells.Cancer Microenvironment2013
23523615Differential sensitivities of glioblastoma cell lines towards metabolic and signaling pathway inhibitions.Cancer Letters2013
23701950AKT upregulates B-Raf Ser445 phosphorylation and ERK1/2 activation in prostate cancer cells in response to androgen depletion.Experimental Cell Research2013
22174156R-Ras is required for murine dendritic cell maturation and CD4+ T-cell priming.Blood2012
21901167Cooperative Cross-Talk between Neuroblastoma Subtypes Confers Resistance to Anaplastic Lymphoma Kinase Inhibition.Genes and Cancer2011
21486223Post-translational modifications of PTEN and their potential therapeutic implications.Current Cancer Drug Targets2011
22103913Characterization of a novel PTEN mutation in MDA-MB-453 breast carcinoma cell line.BMC Cancer2011
18309063Inquiry learning. Integrating content detail and critical reasoning by peer review.Science2008
18323015Teaching resources. Using web-based discussion forums as a model of the peer-review process and a tool for assessment.Sci Signal2008
17514651Functional inactivation of the KLF6 tumor suppressor gene by loss of heterozygosity and increased alternative splicing in glioblastoma.Int J Cancer2007
17565999Regulation of PTEN activity by its carboxyl-terminal autoinhibitory domain.Journal of Biological Chemistry2007
16980617Characterization of R-ras3/m-ras null mice reveals a potential role in trophic factor signaling.Molecular and Cellular Biology2006
15994951Targeted inhibition of the KLF6 splice variant, KLF6 SV1, suppresses prostate cancer cell growth and spread.Cancer Res2005
15713951Teaching resources. Ras-MAPK pathways.2005
15601624TIM, a Dbl-related protein, regulates cell shape and cytoskeletal organization in a Rho-dependent manner.Cellular Signalling2005
15637588The human tumour suppressor PTEN regulates longevity and dauer formation in Caenorhabditis elegans.Oncogene2005
15064720Suppression of glioblastoma tumorigenicity by the Kruppel-like transcription factor KLF6.Oncogene2004
12138204R-Ras3/M-Ras induces neuronal differentiation of PC12 cells through cell-type-specific activation of the mitogen-activated protein kinase cascade.Molecular and Cellular Biology2002
12498708A putative link between exocytosis and tumor development.Cancer Cell2002
12151397Induction of homologue of Slimb ubiquitin ligase receptor by mitogen signaling.Journal of Biological Chemistry2002
12086876Small GTPases and tyrosine kinases coregulate a molecular switch in the phosphoinositide 3-kinase regulatory subunit.Cancer Cell2002
11431330Regulation of PTEN binding to MAGI-2 by two putative phosphorylation sites at threonine 382 and 383.Cancer Research2001
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