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Author Details

Gilles P van Wezel
Institute of Biology, Leiden University
1991
201
48
PMIDPaper TitleJournal TitlePublished Year
36383329FtsZ phosphorylation pleiotropically affects Z-ladder formation, antibiotic production, and morphogenesis in Streptomyces coelicolor.Antonie Van Leeuwenhoek2023
37801665CUBIC: A Versatile Cumate-Based Inducible CRISPRi System in <i>Streptomyces</i>.ACS Synth Biol2023
37902333The plant stress hormone jasmonic acid evokes defensive responses in streptomycetes.Appl Environ Microbiol2023
37697042Artificial intelligence for natural product drug discovery.Nat Rev Drug Discov2023
37982622Systems-wide analysis of the ROK-family regulatory gene <i>rokL6</i> and its role in the control of glucosamine toxicity in <i>Streptomyces coelicolor</i>.Appl Environ Microbiol2023
37541197A widely distributed gene cluster compensates for uricase loss in hominids.Cell2023
37417553Dynamic effects of probiotic formula ecologic®825 on human small intestinal ileostoma microbiota: a network theory approach.Gut Microbes2023
37000899Total Synthesis and Structure Assignment of the Relacidine Lipopeptide Antibiotics and Preparation of Analogues with Enhanced Stability.ACS Infect Dis2023
36999338Volatile sensation: The chemical ecology of the earthy odorant geosmin.Environ Microbiol2023
36584241Chemical Proteomics Reveals Antibiotic Targets of Oxadiazolones in MRSA.J Am Chem Soc2023
36680940The SepF-like proteins SflA and SflB prevent ectopic localization of FtsZ and DivIVA during sporulation of Streptomyces coelicolor.Biochem Biophys Res Commun2023
36563750Reproducible switching between a walled and cell wall-deficient lifestyle of actinomycetes using gradient agar plates.J Microbiol Methods2023
34612321Biosynthesis, evolution and ecology of microbial terpenoids.Nat Prod Rep2022
35775972ActinoBase: tools and protocols for researchers working on <i>Streptomyces</i> and other filamentous actinobacteria.Microb Genom2022
35575488System-Wide Analysis of the GATC-Binding Nucleoid-Associated Protein Gbn and Its Impact on <i>Streptomyces</i> Development.mSystems2022
35357207Role for a Lytic Polysaccharide Monooxygenase in Cell Wall Remodeling in Streptomyces coelicolor.mBio2022
36697563The ubiquitous catechol moiety elicits siderophore and angucycline production in Streptomyces.Commun Chem2022
36138004Endocytosis-like DNA uptake by cell wall-deficient bacteria.Nat Commun2022
36378506A BioBricks Metabolic Engineering Platform for the Biosynthesis of Anthracyclinones in <i>Streptomyces coelicolor</i>.ACS Synth Biol2022
34951423Anthracyclines: biosynthesis, engineering and clinical applications.Nat Prod Rep2022
35181725Discovery of actinomycin L, a new member of the actinomycin family of antibiotics.Sci Rep2022
32935693New developments in RiPP discovery, enzymology and engineering.Nat Prod Rep2021
33824209An Alternative and Conserved Cell Wall Enzyme That Can Substitute for the Lipid II Synthase MurG.mBio2021
33622102Ectopic positioning of the cell division plane is associated with single amino acid substitutions in the FtsZ-recruiting SsgB in <i>Streptomyces</i>.Open Biol2021
33589842A community resource for paired genomic and metabolomic data mining.Nat Chem Biol2021
33563841Competition Sensing Changes Antibiotic Production in <i>Streptomyces</i>.mBio2021
34977585Correction: Glycosylated cyclophellitol-derived activity-based probes and inhibitors for cellulases.RSC Chem Biol2021
34100635Dissecting Disease-Suppressive Rhizosphere Microbiomes by Functional Amplicon Sequencing and 10ÿ Metagenomics.mSystems2021
33978755antiSMASH 6.0: improving cluster detection and comparison capabilities.Nucleic Acids Res2021
33383297Omics-based strategies to discover novel classes of RiPP natural products.Curr Opin Biotechnol2021
31393002Spatial structure increases the benefits of antibiotic production in Streptomyces.Evolution2020
34458755Glycosylated cyclophellitol-derived activity-based probes and inhibitors for cellulases.RSC Chem Biol2020
32060816Genome rearrangements and megaplasmid loss in the filamentous bacterium Kitasatospora viridifaciens are associated with protoplast formation and regeneration.Antonie Van Leeuwenhoek2020
31998842Antibiotic production in <i>Streptomyces</i> is organized by a division of labor through terminal genomic differentiation.Sci Adv2020
31700119Production of ammonia as a low-cost and long-distance antibiotic strategy by Streptomyces species.ISME J2020
32053363Rational Design of Mechanism-Based Inhibitors and Activity-Based Probes for the Identification of Retaining α-l-Arabinofuranosidases.J Am Chem Soc2020
32070256Microbial and volatile profiling of soils suppressive to <i>Fusarium culmorum</i> of wheat.Proc Biol Sci2020
33256178Prodiginines Postpone the Onset of Sporulation in <i>Streptomyces coelicolor</i>.Antibiotics (Basel)2020
33351797Expansion of RiPP biosynthetic space through integration of pan-genomics and machine learning uncovers a novel class of lanthipeptides.PLoS Biol2020
32691599Atypical Spirotetronate Polyketides Identified in the Underexplored Genus <i>Streptacidiphilus</i>.J Org Chem2020
32942174Enzyme-Constrained Models and Omics Analysis of <i>Streptomyces coelicolor</i> Reveal Metabolic Changes that Enhance Heterologous Production.iScience2020
32873609RRE-Finder: a Genome-Mining Tool for Class-Independent RiPP Discovery.mSystems2020
32840360Functional and Structural Insights into a Novel Promiscuous Ketoreductase of the Lugdunomycin Biosynthetic Pathway.ACS Chem Biol2020
32555532Teichoic acids anchor distinct cell wall lamellae in an apically growing bacterium.Commun Biol2020
32483324Ecology and genomics of Actinobacteria: new concepts for natural product discovery.Nat Rev Microbiol2020
32452104The ROK-family regulator Rok7B7 directly controls carbon catabolite repression, antibiotic biosynthesis, and morphological development in Streptomyces avermitilis.Environ Microbiol2020
30621999Streptomyces coelicolor.Trends Microbiol2019
31672892Pathogen-induced activation of disease-suppressive functions in the endophytic root microbiome.Science2019
31641814A microbial expression system for high-level production of scFv HIV-neutralizing antibody fragments in Escherichia coli.Appl Microbiol Biotechnol2019
31409675A Single Biosynthetic Gene Cluster Is Responsible for the Production of Bagremycin Antibiotics and Ferroverdin Iron Chelators.mBio2019
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Collaborators

Joost Willemse
Institute of Biology, Leiden University
Co-authored papers 31
Marnix H Medema
Wageningen University
Co-authored papers 14
Bj??rn A Traag
Harvard University
Co-authored papers 12
Pieter C Dorrestein
Co-authored papers 4
A M Mommaas
Leiden University Medical Center
Co-authored papers 4
Hans-Peter Klenk
Co-authored papers 3
Kai Blin
Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark
Co-authored papers 3
Mitchell D Miller
Rice University
Co-authored papers 2
Adam Godzik
University of California Riverside
Co-authored papers 2
Daniel Petras
Co-authored papers 2
Qingping Xu
Argonne National Laboratory
Co-authored papers 2
Michael A Fischbach
Stanford University
Co-authored papers 2
Hsiu-Ju Chiu
Joint Center for Structural Genomics
Co-authored papers 2
Scott A Lesley
Merck & Co., Inc.
Co-authored papers 2
Mark W Knuth
Joint Center for Structural Genomics
Co-authored papers 2
Florian Huber
Co-authored papers 2
William H Gerwick
Scripps Institution of Oceanography, University of California San Diego
Co-authored papers 2
Neha Garg
Co-authored papers 2
Ashley M Deacon
Accelero Biostructures Inc., USA XPose Therapeutics Inc.
Co-authored papers 2
Marc-Andr?? Elsliger
Joint Center for Structural Genomics
Co-authored papers 2
Heath E Klock
Merck & Co., Inc.
Co-authored papers 2
Ole N Jensen
VILLUM Center for Bioanalytical Sciences, University of Southern Denmark
Co-authored papers 2
Eriko Takano
Manchester Institute of Biotechnology, University of Manchester
Co-authored papers 2
Ian A Wilson
The Scripps Research Institute, USA The Skaggs Institute for Chemical Biology
Co-authored papers 2
Lukasz Jaroszewski
University of California Riverside School of Medicine
Co-authored papers 2
Daniel McMullan
Genomics Institute of the Novartis Research Foundation
Co-authored papers 1
Marc C Deller
Incyte Corporation
Co-authored papers 1
Sanjay Krishna
Institute of Science, Banaras Hindu University
Co-authored papers 1
Dana Weekes
Joint Center for Structural Genomics, Sanford-Burnham Medical Research Institute
Co-authored papers 1
Jon Clardy
Harvard Medical School, Blavatnik Institute
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Release 1.2