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Author Details

Lauren M Hook
Perelman School of Medicine, University of Pennsylvania
2000
30
17
PMIDPaper TitleJournal TitlePublished Year
37243234Novel Adjuvant S-540956 Targets Lymph Nodes and Reduces Genital Recurrences and Vaginal Shedding of HSV-2 DNA When Administered with HSV-2 Glycoprotein D as a Therapeutic Vaccine in Guinea Pigs.Viruses2023
37515169A Trivalent HSV-2 gC2, gD2, gE2 Nucleoside-Modified mRNA-LNP Vaccine Provides Outstanding Protection in Mice against Genital and Non-Genital HSV-1 Infection, Comparable to the Same Antigens Derived from HSV-1.Viruses2023
35336946Antibodies to Crucial Epitopes on HSV-2 Glycoprotein D as a Guide to Dosing an mRNA Genital Herpes Vaccine.Viruses2022
34618692Trivalent nucleoside-modified mRNA vaccine yields durable memory B cell protection against genital herpes in preclinical models.J Clin Invest2021
33555594Techniques for Characterizing Cytomegalovirus-Encoded miRNAs.Methods Mol Biol2021
34936238Guinea Pig and Mouse Models for Genital Herpes Infection.Curr Protoc2021
32347775Herpes simplex virus type 2 trivalent protein vaccine containing glycoproteins C, D and E protects guinea pigs against HSV-1 genital infection.Hum Vaccin Immunother2020
32716975An HSV-2 nucleoside-modified mRNA genital herpes vaccine containing glycoproteins gC, gD, and gE protects mice against HSV-1 genital lesions and latent infection.PLoS Pathog2020
32272093Vaccines to prevent genital herpes.Transl Res2020
30551986A trivalent gC2/gD2/gE2 vaccine for herpes simplex virus generates antibody responses that block immune evasion domains on gC2 better than natural infection.Vaccine2019
31541030Nucleoside-modified mRNA encoding HSV-2 glycoproteins C, D, and E prevents clinical and subclinical genital herpes.Sci Immunol2019
31153687Antibody responses to crucial functional epitopes as a novel approach to assess immunogenicity of vaccine adjuvants.Vaccine2019
29791513Vaccine-induced antibodies to herpes simplex virus glycoprotein D epitopes involved in virus entry and cell-to-cell spread correlate with protection against genital disease in guinea pigs.PLoS Pathog2018
30068491The Revised 2017 MSPE: Better, But Not "Outstanding".J Surg Educ2018
30064582Improving Information Transfer during Transitions of Care <i>via</i> Standardized Handoffs.Am Surg2018
28270578Human Cytomegalovirus MicroRNAs miR-US5-1 and miR-UL112-3p Block Proinflammatory Cytokine Production in Response to NF-κB-Activating Factors through Direct Downregulation of IKKα and IKKβ.mBio2017
28481687A trivalent subunit antigen glycoprotein vaccine as immunotherapy for genital herpes in the guinea pig genital infection model.Hum Vaccin Immunother2017
28103319An HSV-2 Trivalent Vaccine Is Immunogenic in Rhesus Macaques and Highly Efficacious in Guinea Pigs.PLoS Pathog2017
24629342Cytomegalovirus miRNAs target secretory pathway genes to facilitate formation of the virion assembly compartment and reduce cytokine secretion.Cell Host Microbe2014
24769092Cytomegalovirus microRNAs.Curr Opin Virol2014
24639227Techniques for characterizing cytomegalovirus-encoded miRNAs.Methods Mol Biol2014
21900172Human cytomegalovirus US7 is regulated synergistically by two virally encoded microRNAs and by two distinct mechanisms.J Virol2011
20585629A viral microRNA down-regulates multiple cell cycle genes through mRNA 5'UTRs.PLoS Pathog2010
18087721The functions of herpesvirus-encoded microRNAs.Med Microbiol Immunol2008
18480440Blocking antibody access to neutralizing domains on glycoproteins involved in entry as a novel mechanism of immune evasion by herpes simplex virus type 1 glycoproteins C and E.J Virol2008
16571820Herpes simplex virus type 1 and 2 glycoprotein C prevents complement-mediated neutralization induced by natural immunoglobulin M antibody.J Virol2006
15367593Short interfering RNA-mediated inhibition of herpes simplex virus type 1 gene expression and function during infection of human keratinocytes.J Virol2004
12414952Characterization of a novel murine retrovirus mixture that facilitates hematopoiesis.J Virol2002
12186907Herpes simplex virus type 1 evades the effects of antibody and complement in vivo.J Virol2002
10982330Genetics of mouse mammary tumor virus-induced mammary tumors: linkage of tumor induction to the gag gene.J Virol2000
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Collaborators

Jay A Nelson
Oregon Health and Science University
Co-authored papers 7
Drew Weissman
Co-authored papers 6
Igor Landais
Vaccine and Gene Therapy Institute, Oregon Health and Sciences University
Co-authored papers 5
Meaghan H Hancock
Vaccine and Gene Therapy Institute, Oregon Health & Science University
Co-authored papers 5
Finn Grey
The Roslin Institute, The University of Edinburgh
Co-authored papers 4
Norbert Pardi
Co-authored papers 3
Rebecca S Tirabassi
Vaccine and Gene Therapy Institute, Oregon Health & Sciences University
Co-authored papers 3
William J Britt
Heersink School of Medicine, University of Alabama at Birmingham
Co-authored papers 2
Robert Grabski
University of Alabama
Co-authored papers 2
Shannon K McWeeney
Oregon Health & Science University, University of California Berkeley
Co-authored papers 2
Heather L Meyers
Co-authored papers 2
Lindsey B Crawford
Vaccine and Gene Therapy Institute, Oregon Health & Science University
Co-authored papers 1
Katalin Karikó
Co-authored papers 1
Tracy J Doyle
Brigham and Women's Hospital, Harvard Medical School
Co-authored papers 1
Guanming Wu
Oregon Health and Science University
Co-authored papers 1
John D Lambris
Co-authored papers 1
Nicole L Diggins
Vaccine and Gene Therapy Institute, Oregon Health & Science University
Co-authored papers 1
Amy S Espeseth
Merck & Co., Inc.
Co-authored papers 1
Sophia Jeng
Knight Cancer Institute, Oregon Health & Science University
Co-authored papers 1
Release 1.2