Author details

Full Name

Dolores Hambardzumyan

Affiliation

ORCID

Career Start Year

2007

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36594465	Monocyte-neutrophil entanglement in glioblastoma.		2023
37733448	A paracrine circuit of IL-1Î²/IL-1R1 between myeloid and tumor cells drives genotype-dependent glioblastoma progression.		2023
37208357	YB1 modulates the DNA damage response in medulloblastoma.	Sci Rep	2023
37012245	Monocyte depletion enhances neutrophil influx and proneural to mesenchymal transition in glioblastoma.		2023
37451272	Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling.	Cancer Cell	2023
37451265	Hypoxic niches attract and sequester tumor-associated macrophages and cytotoxic T cells and reprogram them for immunosuppression.		2023
37322047	Author Correction: YB1 modulates the DNA damage response in medulloblastoma.	Sci Rep	2023
35747808	Medulloblastoma and the DNA Damage Response.	Frontiers in Oncology	2022
35524725	A novel mouse model of diffuse midline glioma initiated in neonatal oligodendrocyte progenitor cells highlights cell-of-origin dependent effects of H3K27M.	GLIA	2022
35879332	Integrin Î±3Î²1 promotes vessel formation of glioblastoma-associated endothelial cells through calcium-mediated macropinocytosis and lysosomal exocytosis.	Nature Communications	2022
34586841	G-CSF secreted by mutant IDH1 glioma stem cells abolishes myeloid cell immunosuppression and enhances the efficacy of immunotherapy.	Science advances	2021
33856022	Tumour immune landscape of paediatric high-grade gliomas.	Brain	2021
34281988	CD137 and PD-L1 targeting with immunovirotherapy induces a potent and durable antitumor immune response in glioblastoma models.	J Immunother Cancer	2021
34157482	Current knowledge on the immune microenvironment and emerging immunotherapies in diffuse midline glioma.	eBioMedicine	2021
33766119	Macrophages and microglia: the cerberus of glioblastoma.	Acta neuropathologica communications	2021
34087163	Macrophage-tumor cell intertwine drives the transition into a mesenchymal-like cellular state of glioblastoma.	Cancer Cell	2021
33300045	Platelet-derived growth factor beta is a potent inflammatory driver in paediatric high-grade glioma.	Brain	2021
34818553	Protein kinase C and SRC signaling define reciprocally related subgroups of glioblastoma with distinct therapeutic vulnerabilities.	Cell Reports	2021
32621641	Multimodal single-cell analysis reveals distinct radioresistant stem-like and progenitor cell populations in murine glioma.	Glia	2020
31915069	Correction to: Comprehensive gene expression meta-analysis identifies signature genes that distinguish microglia from peripheral monocytes/macrophages in health and glioma.	Acta Neuropathol Commun	2020
32060170	The VGF-derived Peptide TLQP21 Impairs Purinergic Control of Chemotaxis and Phagocytosis in Mouse Microglia.	Journal of Neuroscience	2020
32639068	Genetic driver mutations introduced in identical cell-of-origin in murine glioblastoma reveal distinct immune landscapes but similar response to checkpoint blockade.	Glia	2020
33020472	Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression.	Nat Commun	2020
30718358	Targeting APLN/APLNR Improves Antiangiogenic Efficiency and Blunts Proinvasive Side Effects of VEGFA/VEGFR2 Blockade in Glioblastoma.	Cancer Res	2019
31646100	Human Mesenchymal glioblastomas are characterized by an increased immune cell presence compared to Proneural and Classical tumors.	OncoImmunology	2019
31665239	Tumour-associated macrophage-derived interleukin-1 mediates glioblastoma-associated cerebral oedema.	Brain	2019
30629778	Chromodomain Helicase DNA-Binding Protein 7 Is Suppressed in the Perinecrotic/Ischemic Microenvironment and Is a Novel Regulator of Glioblastoma Angiogenesis.	Stem Cells	2019
30764877	Comprehensive gene expression meta-analysis identifies signature genes that distinguish microglia from peripheral monocytes/macrophages in health and glioma.	Acta Neuropathol Commun	2019
31235603	Intravital 2-photon imaging reveals distinct morphology and infiltrative properties of glioblastoma-associated macrophages.	Proceedings of the National Academy of Sciences of the United States of America	2019
30760578	IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response.	Sci Transl Med	2019
30852603	Inhibition of mutant PPM1D enhances DNA damage response and growth suppressive effects of ionizing radiation in diffuse intrinsic pontine glioma.	Neuro-Oncology	2019
31160587	Tumour-associated macrophages exhibit anti-tumoural properties in Sonic Hedgehog medulloblastoma.	Nat Commun	2019
29409010	Reactive species balance via GTP cyclohydrolase I regulates glioblastoma growth and tumor initiating cell maintenance.	Neuro Oncol	2018
29016864	Loss of host-derived osteopontin creates a glioblastoma-promoting microenvironment.	Neuro-Oncology	2018
30338292	Mitochondrial oxidation of the carbohydrate fuel is required for neural precursor/stem cell function and postnatal cerebellar development.	Science advances	2018
29867979	Immune Microenvironment in Glioblastoma Subtypes.	Frontiers in Immunology	2018
29531161	Activation of the Receptor Tyrosine Kinase AXL Regulates the Immune Microenvironment in Glioblastoma.	Cancer Research	2018
28235764	Cellular and Molecular Identity of Tumor-Associated Macrophages in Glioblastoma.	Cancer Research	2017
28912141	Macropinocytosis of Bevacizumab by Glioblastoma Cells in the Perivascular Niche Affects their Survival.	Clinical Cancer Research	2017
28380429	Ccl5 establishes an autocrine high-grade glioma growth regulatory circuit critical for mesenchymal glioblastoma survival.	Oncotarget	2017
28836293	Genetic driver mutations define the expression signature and microenvironmental composition of high-grade gliomas.	GLIA	2017
28561022	IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression.	Nature Communications	2017
28007996	Reply: Corticosteroids compromise survival in glioblastoma in part through their elevation of blood glucose levels.	Brain	2017
26713745	The role of microglia and macrophages in glioma maintenance and progression.	Nature Neuroscience	2016
27020328	Corticosteroids compromise survival in glioblastoma.	Brain	2016
27210745	Ly6C(hi) Monocytes Provide a Link between Antibiotic-Induced Changes in Gut Microbiota and Adult Hippocampal Neurogenesis.	Cell Reports	2016
24488013	EphA2 promotes infiltrative invasion of glioma stem cells in vivo through cross-talk with Akt and regulates stem cell properties.	Oncogene	2015
25579983	Myeloid derived suppressor cell infiltration of murine and human gliomas is associated with reduction of tumor infiltrating lymphocytes.	J Neurooncol	2015
25658639	Glioma-associated microglia/macrophages display an expression profile different from M1 and M2 polarization and highly express Gpnmb and Spp1.	PLoS ONE	2015
27088132	Glioblastoma: Defining Tumor Niches.	Trends Cancer	2015