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Author Details

Linda Chelico
University of Saskatchewan, College of Medicine
2003
56
25
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36851677Stability of APOBEC3F in the Presence of the APOBEC3 Antagonist HIV-1 Vif Increases at the Expense of Co-Expressed APOBEC3H Haplotype I.Viruses2023
37324648Similar deamination activities but different phenotypic outcomes induced by APOBEC3 enzymes in breast epithelial cells.Front Genome Ed2023
36480186The Cytidine Deaminase APOBEC3G Contributes to Cancer Mutagenesis and Clonal Evolution in Bladder Cancer.Cancer Res2023
36146779Small-Angle X-ray Scattering (SAXS) Measurements of APOBEC3G Provide Structural Basis for Binding of Single-Stranded DNA and Processivity.Viruses2022
36444883Competition for DNA binding between the genome protector replication protein A and the genome modifying APOBEC3 single-stranded DNA deaminases.Nucleic Acids Res2022
33330905APOBEC1 cytosine deaminase activity on single-stranded DNA is suppressed by replication protein A.Nucleic Acids Res2021
34666043Divergence in Dimerization and Activity of Primate APOBEC3C.J Mol Biol2021
34452478Special Issue "APOBECs and Virus Restriction".Viruses2021
34389466Characterization of an A3G-Vif<sub>HIV-1</sub>-CRL5-CBFβ Structure Using a Cross-linking Mass Spectrometry Pipeline for Integrative Modeling of Host-Pathogen Complexes.Mol Cell Proteomics2021
34132575APOBEC3F Constitutes a Barrier to Successful Cross-Species Transmission of Simian Immunodeficiency Virus SIVsmm to Humans.J Virol2021
34200141Examination of the APOBEC3 Barrier to Cross Species Transmission of Primate Lentiviruses.Viruses2021
34170969Highly-potent, synthetic APOBEC3s restrict HIV-1 through deamination-independent mechanisms.PLoS Pathog2021
32132362Perspectives of Saskatchewan researchers and community members on HIV-1 strains circulating in Saskatchewan.AIDS2020
32005813Understanding the structural basis of HIV-1 restriction by the full length double-domain APOBEC3G.Nat Commun2020
31943071Deamination hotspots among APOBEC3 family members are defined by both target site sequence context and ssDNA secondary structure.Nucleic Acids Res2020
33196045APOBEC3 enzymes mediate efficacy of cisplatin and are epistatic with base excision repair and mismatch repair in platinum response.NAR Cancer2020
33292100The interesting relationship between APOBEC3 deoxycytidine deaminases and cancer: a long road ahead.Open Biol2020
32984821Single-nucleotide polymorphism of the DNA cytosine deaminase APOBEC3H haplotype I leads to enzyme destabilization and correlates with lung cancer.NAR Cancer2020
30448640Polymorphisms of the cytidine deaminase APOBEC3F have different HIV-1 restriction efficiencies.Virology2019
31850845HIV restriction factor APOBEC3G binds in multiple steps and conformations to search and deaminate single-stranded DNA.Elife2019
31152065Structure of Ddi2, a highly inducible detoxifying metalloenzyme from <i>Saccharomyces cerevisiae</i>.J Biol Chem2019
30797859APOBEC3 Host Restriction Factors of HIV-1 Can Change the Template Switching Frequency of Reverse Transcriptase.J Mol Biol2019
31025011Role of co-expressed APOBEC3F and APOBEC3G in inducing HIV-1 drug resistance.Heliyon2019
29347817Biochemical Basis of APOBEC3 Deoxycytidine Deaminase Activity on Diverse DNA Substrates.ACS Infect Dis2018
30395282Corrigendum: Enzyme cycling contributes to efficient induction of genome mutagenesis by the cytidine deaminase APOBEC3B.Nucleic Acids Res2018
30414963RNA-Mediated Dimerization of the Human Deoxycytidine Deaminase APOBEC3H Influences Enzyme Activity and Interaction with Nucleic Acids.J Mol Biol2018
27881650Mechanism of Enhanced HIV Restriction by Virion Coencapsidated Cytidine Deaminases APOBEC3F and APOBEC3G.J Virol2017
28158858Cytidine deaminase efficiency of the lentiviral viral restriction factor APOBEC3C correlates with dimerization.Nucleic Acids Res2017
28289235Correction for Baig et al., Determinants of Efficient Degradation of APOBEC3 Restriction Factors by HIV-1 Vif.J Virol2017
28981865Enzyme cycling contributes to efficient induction of genome mutagenesis by the cytidine deaminase APOBEC3B.Nucleic Acids Res2017
28883657Deamination-independent restriction of LINE-1 retrotransposition by APOBEC3H.Sci Rep2017
28928403Dimerization regulates both deaminase-dependent and deaminase-independent HIV-1 restriction by APOBEC3G.Nat Commun2017
27650891The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis.Nat Commun2016
27732658A Single Nucleotide Polymorphism in Human APOBEC3C Enhances Restriction of Lentiviruses.PLoS Pathog2016
26396192Natural Polymorphisms and Oligomerization of Human APOBEC3H Contribute to Single-stranded DNA Scanning Ability.J Biol Chem2015
24651717Different mutagenic potential of HIV-1 restriction factors APOBEC3G and APOBEC3F is determined by distinct single-stranded DNA scanning mechanisms.PLoS Pathog2014
25206352Suppression of APOBEC3-mediated restriction of HIV-1 by Vif.Front Microbiol2014
25275135Determinants of efficient degradation of APOBEC3 restriction factors by HIV-1 Vif.J Virol2014
23316055HIV-1 viral infectivity factor (Vif) alters processive single-stranded DNA scanning of the retroviral restriction factor APOBEC3G.J Biol Chem2013
23717565Retroviral restriction factor APOBEC3G delays the initiation of DNA synthesis by HIV-1 reverse transcriptase.PLoS One2013
22362763Single-stranded DNA scanning and deamination by APOBEC3G cytidine deaminase at single molecule resolution.J Biol Chem2012
22822074Biochemical analysis of hypermutation by the deoxycytidine deaminase APOBEC3A.J Biol Chem2012
21300806Intensity of deoxycytidine deamination of HIV-1 proviral DNA by the retroviral restriction factor APOBEC3G is mediated by the noncatalytic domain.J Biol Chem2011
20212048Structural model for deoxycytidine deamination mechanisms of the HIV-1 inactivation enzyme APOBEC3G.J Biol Chem2010
19022738Stochastic properties of processive cytidine DNA deaminases AID and APOBEC3G.Philos Trans R Soc Lond B Biol Sci2009
19684020Biochemical basis of immunological and retroviral responses to DNA-targeted cytosine deamination by activation-induced cytidine deaminase and APOBEC3G.J Biol Chem2009
19421154Mechanisms of APOBEC3G-catalyzed processive deamination of deoxycytidine on single-stranded DNA.Nat Struct Mol Biol2009
19136562Dissecting APOBEC3G substrate specificity by nucleoside analog interference.J Biol Chem2009
18005981Isolation and characterization of nucleotide excision repair deficient mutants of the entomopathogenic fungus, Beauveria bassiana.J Invertebr Pathol2008
18849968Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications.Nature2008
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Collaborators

Yuqing Feng
University of Toronto
Co-authored papers 15
Michael Emerman
Fred Hutchinson Cancer Center
Co-authored papers 4
Andrej Sali (CM4AI)
University of California San Francisco
Co-authored papers 1
Michael A Carpenter
University of Minnesota
Co-authored papers 1
Michael McDonald
University of Central Florida
Co-authored papers 1
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Caryl and Israel Englander Institute for Precision Medicine
Co-authored papers 1
Ignacia Echeverria
University of California san francisco
Co-authored papers 1
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 1
Raymond C Stevens
iHuman Institute, ShanghaiTech University
Co-authored papers 1
Elena Harjes
Massey University
Co-authored papers 1
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J. David Gladstone Institutes
Co-authored papers 1
John Gross
Co-authored papers 1
Bishoy M Faltas
Sandra and Edward Meyer Cancer Center
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Baylor College of Medicine
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Lan Huang
University of California Irvine
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Clinton Yu
University of California Irvine
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Meyer Cancer Center
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Memorial Sloan Kettering Cancer Center, USA Memorial Sloan Kettering Cancer Center
Co-authored papers 1
Franco J Vizeacoumar
College of Medicine, University of Saskatchewan
Co-authored papers 1
Seung Joong Kim
Korea Advanced Institute of Science and Technology (KAIST)
Co-authored papers 1
John Von Dollen
University of California San Francisco
Co-authored papers 1
Frederick S Vizeacoumar
College of Medicine, University of Saskatchewan
Co-authored papers 1
James S Fraser
University of California san francisco
Co-authored papers 1
Nicholas M Chesarino
Fred Hutchinson Cancer Center
Co-authored papers 1
Timothy M Ryan
Pennsylvania State University, State College
Co-authored papers 1
Reuben S Harris
University of Texas Health San Antonio
Co-authored papers 1
Andrea Sboner
Institute for Computational Biomedicine
Co-authored papers 1
Beatrice H Hahn
Co-authored papers 1
Release 1.2