Author details

Full Name

Dennis P M Hughes

Affiliation

ORCID

Career Start Year

1995

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
26411434	Cardiovascular involvement by osteosarcoma: an analysis of 20 patients.	Pediatr Radiol	2016
24203492	The narrow-spectrum HDAC inhibitor entinostat enhances NKG2D expression without NK cell toxicity, leading to enhanced recognition of cancer cells.	Pharm Res	2015
25336699	New, tolerable Î³-secretase inhibitor takes desmoid down a notch.	Clin Cancer Res	2015
25629952	Improving paclitaxel delivery: in vitro and in vivo characterization of PEGylated polyphosphoester-based nanocarriers.	Journal of the American Chemical Society	2015
25598116	Health disparities are important determinants of outcome for children with solid tumor malignancies.	Journal of Pediatric Surgery	2015
25598115	Effect of concurrent metastatic disease on survival in children and adolescents undergoing lung resection for metastatic osteosarcoma.	Journal of Pediatric Surgery	2015
26008821	Correction to "Improving Paclitaxel Delivery: In Vitro and In Vivo Characterization of PEGylated Polyphosphoester-Based Nanocarriers".	Journal of the American Chemical Society	2015
26002157	Bone Sarcomas in Pediatrics: Progress in Our Understanding of Tumor Biology and Implications for Therapy.	Paediatric Drugs	2015
24924169	Understanding the role of Notch in osteosarcoma.	Advances in Experimental Medicine and Biology	2014
23997016	Mifamurtide in metastatic and recurrent osteosarcoma: a patient access study with pharmacokinetic, pharmacodynamic, and safety assessments.	Pediatric Blood and Cancer	2014
24136885	Natural killer cell therapy and aerosol interleukin-2 for the treatment of osteosarcoma lung metastasis.	Pediatric Blood and Cancer	2014
24924170	Developmental pathways hijacked by osteosarcoma.	Advances in Experimental Medicine and Biology	2014
24062983	Understanding the Biology of Bone Sarcoma from Early Initiating Events through Late Events in Metastasis and Disease Progression.	Frontiers in Oncology	2013
22990745	UBE4B levels are correlated with clinical outcomes in neuroblastoma patients and with altered neuroblastoma cell proliferation and sensitivity to epidermal growth factor receptor inhibitors.	Cancer	2013
24046071	Retraction: Critical role of notch signaling in osteosarcoma invasion and metastasis.	Clinical Cancer Research	2013
23936456	Small molecule ErbB inhibitors decrease proliferative signaling and promote apoptosis in philadelphia chromosome-positive acute lymphoblastic leukemia.	PLoS One	2013
23845614	Complications in the surgical treatment of pediatric melanoma.	Journal of Pediatric Surgery	2013
22186140	miR-20a encoded by the miR-17-92 cluster increases the metastatic potential of osteosarcoma cells by regulating Fas expression.	Cancer Research	2012
22682314	Triplex DNA-binding proteins are associated with clinical outcomes revealed by proteomic measurements in patients with colorectal cancer.	Molecular Cancer	2012
22415601	Slow down to stay alive: HER4 protects against cellular stress and confers chemoresistance in neuroblastoma.	Cancer	2012
22764137	Anti-tumor effects of the Notch pathway in gastrointestinal stromal tumors.	Carcinogenesis	2012
21853100	Herceptin conjugates linked by EDC boost direct tumor cell death via programmed tumor cell necrosis.	PLoS ONE	2011
20406948	Driven to death: Inhibition of farnesylation increases Ras activity and promotes growth arrest and cell death [corrected].	Molecular Cancer Therapeutics	2010
20564646	Signaling of ERBB receptor tyrosine kinases promotes neuroblastoma growth in vitro and in vivo.	Cancer	2010
20208568	Regulation of NOTCH signaling by reciprocal inhibition of HES1 and Deltex 1 and its role in osteosarcoma invasiveness.	Oncogene	2010
20023231	Inhibiting platelet-derived growth factor beta reduces Ewing's sarcoma growth and metastasis in a novel orthotopic human xenograft model.	In Vivo	2009
19444103	Novel agents in development for pediatric sarcomas.	Current Opinion in Oncology	2009
19276367	Cetuximab attenuates metastasis and u-PAR expression in non-small cell lung cancer: u-PAR and E-cadherin are novel biomarkers of cetuximab sensitivity.	Cancer Res	2009
19761419	Strategies for the targeted delivery of therapeutics for osteosarcoma.		2009
19840522	Critical signaling pathways in bone sarcoma: candidates for therapeutic interventions.	Current Oncology Reports	2009
20213410	How the NOTCH pathway contributes to the ability of osteosarcoma cells to metastasize.	Cancer Treatment and Research	2009
18483362	Critical role of notch signaling in osteosarcoma invasion and metastasis.	Clinical Cancer Research	2008
18292797	Genetically engineered T cells expressing a HER2-specific chimeric receptor mediate antigen-specific tumor regression.	Cancer Gene Therapy	2008
18922107	Novel bone cancer drugs: investigational agents and control paradigms for primary bone sarcomas (Ewing's sarcoma and osteosarcoma).	Expert Opinion on Investigational Drugs	2008
18213710	Multimodality treatment of osteosarcoma: radiation in a high-risk cohort.	Pediatric Blood and Cancer	2008
17356403	Primary tuberculosis of bone mimicking a lytic bone tumor.	J Pediatr Hematol Oncol	2007
17279585	Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines.	Cancer	2007
16651448	Ex vivo culture with interleukin (IL)-12 improves CD8(+) T-cell adoptive immunotherapy for murine leukemia independent of IL-18 or IFN-gamma but requires perforin.	Cancer Research	2006
16007579	Essential erbB family phosphorylation in osteosarcoma as a target for CI-1033 inhibition.	Pediatr Blood Cancer	2006
16236629	Fate and function of anti-CD3/CD28-activated T cells following adoptive transfer: IL-2 promotes development of anti-tumor memory T cells in vivo.	Cytotherapy	2005
15026342	Cell surface expression of epidermal growth factor receptor and Her-2 with nuclear expression of Her-4 in primary osteosarcoma.	Cancer Res	2004
15566639	[Chimeric T cell receptor N29gamma redirect T lymphocytes response specific to p185HER2 in A murine model of metastatic breast cancer].		2004
11141327	Correction of DiGeorge anomaly with EBV-induced lymphoma by transplantation of organ-cultured thymus and Epstein-Barr-specific cytotoxic T lymphocytes.	Clinical Immunology	2001
8621947	Murine lupus in the absence of alpha beta T cells.	Journal of Immunology	1996
7595210	A naturally occurring soluble isoform of murine Fas generated by alternative splicing.	Journal of Experimental Medicine	1995
7540652	T cells with gamma/delta T cell receptors (TCR) of intestinal type are preferentially expanded in TCR-alpha-deficient lpr mice.	Journal of Experimental Medicine	1995