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Author Details

Horst Kessler
Institute for Advanced Study, Technical University Munich
1966
398
81
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37527778ShlA toxin of Serratia induces P2Y2- and α5β1-dependent autophagy and bacterial clearance from host cells.J Biol Chem2023
35053532Temozolomide-Acquired Resistance Is Associated with Modulation of the Integrin Repertoire in Glioblastoma, Impact of α5β1 Integrin.Cancers (Basel)2022
35398994Molecular Signature of Astrocytes for Gene Delivery by the Synthetic Adeno-Associated Viral Vector rAAV9P1.Adv Sci (Weinh)2022
32970218Multiparametric PET and MRI of myocardial damage after myocardial infarction: correlation of integrin αvβ3 expression and myocardial blood flow.Eur J Nucl Med Mol Imaging2021
33756215The organometallic ferrocene exhibits amplified anti-tumor activity by targeted delivery via highly selective ligands to αvβ3, αvβ6, or α5β1 integrins.Biomaterials2021
33916607RGD-Binding Integrins Revisited: How Recently Discovered Functions and Novel Synthetic Ligands (Re-)Shape an Ever-Evolving Field.Cancers (Basel)2021
34554089Integrin α5β1 nano-presentation regulates collective keratinocyte migration independent of substrate rigidity.Elife2021
34099677Synthetic extracellular matrices with tailored adhesiveness and degradability support lumen formation during angiogenic sprouting.Nat Commun2021
33961417Halting the Spread of Herpes Simplex Virus-1: The Discovery of an Effective Dual αvβ6/αvβ8 Integrin Ligand.J Med Chem2021
33142116Surface Co-presentation of BMP-2 and integrin selective ligands at the nanoscale favors α<sub>5</sub>β<sub>1</sub> integrin-mediated adhesion.Biomaterials2021
32368195Are we curing one evil with another? A translational approach targeting the role of neoatherosclerosis in late stent failure.Eur Heart J Suppl2020
31908168Integrin Subtypes and Nanoscale Ligand Presentation Influence Drug Sensitivity in Cancer Cells.Nano Lett2020
31780581Recruitment of α<sub>ν</sub>β<sub>3</sub> integrin to α<sub>5</sub>β<sub>1</sub> integrin-induced clusters enables focal adhesion maturation and cell spreading.J Cell Sci2020
33159082Identification of phenothiazine derivatives as UHM-binding inhibitors of early spliceosome assembly.Nat Commun2020
33015026Organoids to Study Intestinal Nutrient Transport, Drug Uptake and Metabolism - Update to the Human Model and Expansion of Applications.Front Bioeng Biotechnol2020
32242141Evidence for functional selectivity in TUDC- and norUDCA-induced signal transduction via α<sub>5</sub>β<sub>1</sub> integrin towards choleresis.Sci Rep2020
32427835Assessment of a pro-healing stent in an animal model of early neoatherosclerosis.Sci Rep2020
30649888Differential Modulation of Platelet Adhesion and Spreading by Adhesive Ligand Density.Nano Lett2019
31828445Correction to: In vivo imaging of early stages of rheumatoid arthritis by α5β1-integrin-targeted positron emission tomography.EJNMMI Res2019
31501931In vivo imaging of early stages of rheumatoid arthritis by α5β1-integrin-targeted positron emission tomography.EJNMMI Res2019
31410585Validation of [<sup>125</sup>I]CPCR4.3 as an investigative tool for the sensitive and specific detection of hCXCR4 and mCXCR4 expression in vitro and in vivo.EJNMMI Res2019
30735211Control of stem cell response and bone growth on biomaterials by fully non-peptidic integrin selective ligands.Biomater Sci2019
30657681Selective Targeting of Integrin αvβ8 by a Highly Active Cyclic Peptide.J Med Chem2019
28886995Improving oral bioavailability of cyclic peptides by N-methylation.Bioorg Med Chem2018
29976060Enhancing Oral Bioavailability of Cyclic RGD Hexa-peptides by the Lipophilic Prodrug Charge Masking Approach: Redirection of Peptide Intestinal Permeability from a Paracellular to Transcellular Pathway.Mol Pharm2018
30023833Therapeutic Radiopharmaceuticals Targeting Integrin αvβ6.ACS Omega2018
30144240Orally Active Peptides: Is There a Magic Bullet?Angew Chem Int Ed Engl2018
30088769Combining Adhesive Nanostructured Surfaces and Costimulatory Signals to Increase T Cell Activation.Nano Lett2018
30502043Fluorescence imaging of invasive head and neck carcinoma cells with integrin αvβ6-targeting RGD-peptides: an approach to a fluorescence-assisted intraoperative cytological assessment of bony resection margins.Br J Oral Maxillofac Surg2018
30380298Bioconjugation of Supramolecular Metallacages to Integrin Ligands for Targeted Delivery of Cisplatin.Bioconjug Chem2018
29775303Simultaneous Targeting of RGD-Integrins and Dual Murine Double Minute Proteins in Glioblastoma Multiforme.J Med Chem2018
29605997Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1.J Med Chem2018
29489355N-Methylation of isoDGR Peptides: Discovery of a Selective α5β1-Integrin Ligand as a Potent Tumor Imaging Agent.J Med Chem2018
29660806From a Helix to a Small Cycle: Metadynamics-Inspired αvβ6 Integrin Selective Ligands.Angew Chem Int Ed Engl2018
27940248Integrin-Targeted Hybrid Fluorescence Molecular Tomography/X-ray Computed Tomography for Imaging Tumor Progression and Early Response in Non-Small Cell Lung Cancer.Neoplasia2017
29180787Towards the cell-instructive bactericidal substrate: exploring the combination of nanotopographical features and integrin selective synthetic ligands.Sci Rep2017
29072809Overcoming the Lack of Oral Availability of Cyclic Hexapeptides: Design of a Selective and Orally Available Ligand for the Integrin⿿αvβ3.Angew Chem Int Ed Engl2017
28623309Fibronectin promotes directional persistence in fibroblast migration through interactions with both its cell-binding and heparin-binding domains.Sci Rep2017
28849651Highly Ordered Gold Nanopatterned Indium Tin Oxide Electrodes for Simultaneous Optical and Electrochemical Probing Cell Interactions.Anal Chem2017
28869579Exploring the Role of RGD-Recognizing Integrins in Cancer.Cancers (Basel)2017
28715181Structural Insights into Selective Ligand-Receptor Interactions Leading to Receptor Inactivation Utilizing Selective Melanocortin 3 Receptor Antagonists.Biochemistry2017
28518069Modification and Functionalization of the Guanidine Group by Tailor-made Precursors.J Vis Exp2017
27980050In Vivo PET Imaging of the Cancer Integrin αvβ6 Using <sup>68</sup>Ga-Labeled Cyclic RGD Nonapeptides.J Nucl Med2017
28074920A Comprehensive Evaluation of the Activity and Selectivity Profile of Ligands for RGD-binding Integrins.Sci Rep2017
27112767The influence of different metal-chelate conjugates of pentixafor on the CXCR4 affinity.EJNMMI Res2016
26497698In vivo biokinetic and metabolic characterization of the ⁶⁸Ga-labelled α5β1-selective peptidomimetic FR366.Eur J Nucl Med Mol Imaging2016
26470725Integrin α5β1 and p53 convergent pathways in the control of anti-apoptotic proteins PEA-15 and survivin in high-grade glioma.Cell Death Differ2016
26635338Complementary, Selective PET Imaging of Integrin Subtypes α5β1 and αvβ3 Using 68Ga-Aquibeprin and 68Ga-Avebetrin.J Nucl Med2016
26663700Small Cause, Great Impact: Modification of the Guanidine Group in the RGD Motif Controls Integrin Subtype Selectivity.Angew Chem Int Ed Engl2016
26663660Stable Peptides Instead of Stapled Peptides: Highly Potent αvβ6-Selective Integrin Ligands.Angew Chem Int Ed Engl2016
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Collaborators

Benjamin Geiger
Co-authored papers 7
Wolfgang Baumeister
Max Planck Institute of Biochemistry
Co-authored papers 5
Michael Sattler
Technical University of Munich, Institute of Structural Biology
Co-authored papers 4
Robert Kaptein
Utrecht University
Co-authored papers 3
Bernd Reif
Technische Universitat Munchen (TUM)
Co-authored papers 2
Anthony Watts
Oxford University
Co-authored papers 2
Qi Cheng
CVPath Institute
Co-authored papers 2
Hartmut Oschkinat
Leibniz-Forschungsinstitut fur Molekulare Pharmakologie
Co-authored papers 2
Tobias Madl
Gottfried Schatz Research Center, Medical University of Graz
Co-authored papers 2
Rolf Boelens
Utrecht University
Co-authored papers 2
Michel Dard
Co-authored papers 2
Ute Resch-Genger
Co-authored papers 1
David A Case
Rutgers University
Co-authored papers 1
Oliver F Lange
Center for Integrated Protein Science, Technische Universitat Munchen
Co-authored papers 1
Gordon C K Roberts
Leicester Institute of Structural and Chemical Biology, University of Leicester
Co-authored papers 1
Josep Rizo
University of Texas Southwestern Medical Center
Co-authored papers 1
Mike P Williamson
The University of Sheffield
Co-authored papers 1
David Cowburn
Albert Einstein College of Medicine
Co-authored papers 1
Lu-Yun Lian
Institute of Systems, The University of Liverpool
Co-authored papers 1
Liang Guo
CVPath Institute
Co-authored papers 1
Igor L Barsukov
Institute of Integrative Biology, University of Liverpool
Co-authored papers 1
David E Shaw
Columbia University
Co-authored papers 1
Ad Bax
National Institutes of Health
Co-authored papers 1
Patrick C A van der Wel
Zernike Institute for Advanced Materials, University of Groningen
Co-authored papers 1
David Middleton
Co-authored papers 1
Ioannis Vakonakis
University of Oxford
Co-authored papers 1
Thomas A Frenkiel
The Medical Research Council Biomedical NMR Centre, The Francis Crick Institute
Co-authored papers 1
Ernest D Laue
University of Cambridge
Co-authored papers 1
Leanne E Felkin
Co-authored papers 1
Gordon S Rule
Carnegie Mellon University
Co-authored papers 1
Release 1.2