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Author Details

David S Miller
National Institutes of Health/National Institute of Environmental Health Sciences
1971
171
56
PMIDPaper TitleJournal TitlePublished Year
30913027Aryl hydrocarbon receptor ligands increase ABC transporter activity and protein expression in killifish (Fundulus heteroclitus) renal proximal tubules.Biol Chem2019
28447863Lysophosphatidic acid and amitriptyline signal through LPA1R to reduce P-glycoprotein transport at the blood-brain barrier.J Cereb Blood Flow Metab2018
27193034PPAR-α, a lipid-sensing transcription factor, regulates blood-brain barrier efflux transporter expression.J Cereb Blood Flow Metab2017
28119480Ceramide 1-Phosphate Increases P-Glycoprotein Transport Activity at the Blood-Brain Barrier via Prostaglandin E2 Signaling.Mol Pharmacol2017
28882485Zinc chloride rapidly stimulates efflux transporters in renal proximal tubules of killifish (Fundulus heteroclitus).Toxicol Appl Pharmacol2017
28011392Selective induction of P-glycoprotein at the CNS barriers during symptomatic stage of an ALS animal model.Neurosci Lett2017
26865616Aβ40 Reduces P-Glycoprotein at the Blood-Brain Barrier through the Ubiquitin-Proteasome Pathway.J Neurosci2016
25175835ABC transporter-driven pharmacoresistance in Amyotrophic Lateral Sclerosis.Brain Res2015
26465636In vivo and ex vivo regulation of breast cancer resistant protein (Bcrp) by peroxisome proliferator-activated receptor alpha (Pparα) at the blood-brain barrier.J Neurochem2015
26187753Regulation of ABC efflux transporters at blood-brain barrier in health and neurological disorders.Brain Res2015
25670036Regulation of ABC transporters at the blood-brain barrier.Clin Pharmacol Ther2015
25640266Regulation of ABC transporters blood-brain barrier: the good, the bad, and the ugly.Adv Cancer Res2015
23789954Signaling pathways that regulate basal ABC transporter activity at the blood- brain barrier.Curr Pharm Des2014
25307212ABC transporter regulation by signaling at the blood-brain barrier: relevance to pharmacology.Adv Pharmacol2014
24948812Nrf2 upregulates ATP binding cassette transporter expression and activity at the blood-brain and blood-spinal cord barriers.J Neurosci2014
24931068Effects of deep hypothermic circulatory arrest on the blood brain barrier in a cardiopulmonary bypass model--a pilot study.Heart Lung Circ2014
24483607Reversible dimers of the atypical antipsychotic quetiapine inhibit p-glycoprotein-mediated efflux in vitro with increased binding affinity and in situ at the blood-brain barrier.ACS Chem Neurosci2014
24385389Sphingolipid signaling reduces basal P-glycoprotein activity in renal proximal tubule.J Pharmacol Exp Ther2014
23212123Functional regulation of P-glycoprotein at the blood-brain barrier in proton-coupled folate transporter (PCFT) mutant mice.FASEB J2013
23642074Microglial activation decreases retention of the protease inhibitor saquinavir: implications for HIV treatment.J Neuroinflammation2013
23168528Mrp1 is essential for sphingolipid signaling to p-glycoprotein in mouse blood-brain and blood-spinal cord barriers.J Cereb Blood Flow Metab2013
21866921Toward eradicating HIV reservoirs in the brain: inhibiting P-glycoprotein at the blood-brain barrier with prodrug abacavir dimers.J Am Chem Soc2012
22949658Targeting blood-brain barrier sphingolipid signaling reduces basal P-glycoprotein activity and improves drug delivery to the brain.Proc Natl Acad Sci U S A2012
22981845The outdoor air pollution and brain health workshop.Neurotoxicology2012
230356951α,25-Dihydroxyvitamin D3-liganded vitamin D receptor increases expression and transport activity of P-glycoprotein in isolated rat brain capillaries and human and rat brain microvessel endothelial cells.J Neurochem2012
22472606ABC transporter function and regulation at the blood-spinal cord barrier.J Cereb Blood Flow Metab2012
22521463Selective increase of two ABC drug efflux transporters at the blood-spinal cord barrier suggests induced pharmacoresistance in ALS.Neurobiol Dis2012
19957214Neuromelanin activates microglia and induces degeneration of dopaminergic neurons: implications for progression of Parkinson's disease.Neurotox Res2011
21515814Rapid, nongenomic stimulation of multidrug resistance protein 2 (Mrp2) activity by glucocorticoids in renal proximal tubule.J Pharmacol Exp Ther2011
21487415Activating PKC-β1 at the blood-brain barrier reverses induction of P-glycoprotein activity by dioxin and restores drug delivery to the CNS.J Cereb Blood Flow Metab2011
21048045Aryl hydrocarbon receptor-mediated up-regulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrier.FASEB J2011
21232086Microglial MAC1 receptor and PI3K are essential in mediating β-amyloid peptide-induced microglial activation and subsequent neurotoxicity.J Neuroinflammation2011
20101004Restoring blood-brain barrier P-glycoprotein reduces brain amyloid-beta in a mouse model of Alzheimer's disease.Mol Pharmacol2010
20547735Constitutive androstane receptor-mediated up-regulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrier.Mol Pharmacol2010
20460386Estrogen receptor beta signaling through phosphatase and tensin homolog/phosphoinositide 3-kinase/Akt/glycogen synthase kinase 3 down-regulates blood-brain barrier breast cancer resistance protein.J Pharmacol Exp Ther2010
20628400Rapid loss of blood-brain barrier P-glycoprotein activity through transporter internalization demonstrated using a novel in situ proteolysis protection assay.J Cereb Blood Flow Metab2010
2021654917-β-Estradiol: a powerful modulator of blood-brain barrier BCRP activity.J Cereb Blood Flow Metab2010
20197783Activation of PKC isoform beta(I) at the blood-brain barrier rapidly decreases P-glycoprotein activity and enhances drug delivery to the brain.J Cereb Blood Flow Metab2010
20417575Regulation of P-glycoprotein and other ABC drug transporters at the blood-brain barrier.Trends Pharmacol Sci2010
20107068Rapid, reversible modulation of blood-brain barrier P-glycoprotein transport activity by vascular endothelial growth factor.J Neurosci2010
19371577Prevention of seizure-induced up-regulation of endothelial P-glycoprotein by COX-2 inhibition.Neuropharmacology2009
18094072Seizure-induced up-regulation of P-glycoprotein at the blood-brain barrier through glutamate and cyclooxygenase-2 signaling.Mol Pharmacol2008
18474546Diesel exhaust particles induce oxidative stress, proinflammatory signaling, and P-glycoprotein up-regulation at the blood-brain barrier.FASEB J2008
18560012Modulation of P-glycoprotein at the blood-brain barrier: opportunities to improve central nervous system pharmacotherapy.Pharmacol Rev2008
18650317Texas Red transport across rat and dogfish shark (Squalus acanthias) choroid plexus.Am J Physiol Regul Integr Comp Physiol2008
18218698Peroxisome proliferator-activated receptor-gamma-mediated positive energy balance in the rat is associated with reduced sympathetic drive to adipose tissues and thyroid status.Endocrinology2008
18349876Coordinated nuclear receptor regulation of the efflux transporter, Mrp2, and the phase-II metabolizing enzyme, GSTpi, at the blood-brain barrier.J Cereb Blood Flow Metab2008
18420243Intracellular localization and subsequent redistribution of metal transporters in a rat choroid plexus model following exposure to manganese or iron.Toxicol Appl Pharmacol2008
17954525Localization of P-gp (Abcb1) and Mrp2 (Abcc2) in freshly isolated rat hepatocytes.Drug Metab Dispos2008
16912062Endothelin and calciotropic hormones share regulatory pathways in multidrug resistance protein 2-mediated transport.Am J Physiol Renal Physiol2007
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Collaborators

National Institute of Environmental Health Sciences
Co-authored papers 10
Roche Pharma Research and Early Development
Co-authored papers 10
university of california san diego
Co-authored papers 2
National Institute of Environmental Health Sciences, National Institutes of Health
Co-authored papers 2
University of Guelph
Co-authored papers 1
Duke Cancer Institute
Co-authored papers 1
New York State Psychiatric Institute, Research Foundation for Mental Hygiene
Co-authored papers 1
Co-authored papers 1
Dartmouth College
Co-authored papers 1
Duke University Nicholas School of the Environment.
Co-authored papers 1
Co-authored papers 1
UPMC-Hillman Cancer Center, University of Pittsburgh
Co-authored papers 1
National Institute of Environmental Health Sciences
Co-authored papers 1
Duke University School of Medicine
Co-authored papers 1
Duke University
Co-authored papers 1
12284University of Nebraska Medical Center
Co-authored papers 1
Co-authored papers 1
Center for Precision Environmental Health, Baylor College of Medicine
Co-authored papers 1
Centre de recherche sur le cancer de l'Universite Laval, Universite Laval
Co-authored papers 1
Duke University Medical Center
Co-authored papers 1
Universite de Paris, CNRS
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1
Duke University
Co-authored papers 1
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