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Author Details

Juan Botas
Baylor College of Medicine
1982
82
43
PMIDPaper TitleJournal TitlePublished Year
36173927Integration of transcriptome-wide association study with neuronal dysfunction assays provides functional genomics evidence for Parkinson's disease genes.Hum Mol Genet2023
37219079Tau polarizes an aging transcriptional signature to excitatory neurons and glia.Elife2023
37179358Functional variants identify sex-specific genes and pathways in Alzheimer's Disease.Nat Commun2023
37200393Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity.PLoS Genet2023
37064812Upregulation of the ESCRT pathway and multivesicular bodies accelerates degradation of proteins associated with neurodegeneration.Autophagy Rep2023
36547263An altered extracellular matrix-integrin interface contributes to Huntington's disease-associated CNS dysfunction in glial and vascular cells.Hum Mol Genet2023
36610398Evolutionarily conserved regulators of tau identify targets for new therapies.Neuron2023
36865102SPA-STOCSY: An Automated Tool for Identification of Annotated and Non-Annotated Metabolites in High-Throughput NMR Spectra.bioRxiv2023
34741261Inhibition of HIPK3 by AST487 Ameliorates Mutant HTT-Induced Neurotoxicity and Apoptosis via Enhanced Autophagy.Neurosci Bull2022
35499073Cross-species genetic screens identify transglutaminase 5 as a regulator of polyglutamine-expanded ataxin-1.J Clin Invest2022
35864371Correction: Inhibition of HIPK3 by AST487 Ameliorates Mutant HTT-Induced Neurotoxicity and Apoptosis via Enhanced Autophagy.Neurosci Bull2022
36268052Identification of risk genes for Alzheimer's disease by gene embedding.Cell Genom2022
35148841Dynamics of huntingtin protein interactions in the striatum identifies candidate modifiers of Huntington disease.Cell Syst2022
35238684Suppression of toxicity of the mutant huntingtin protein by its interacting compound, desonide.Proc Natl Acad Sci U S A2022
34990574The developmental roots of neurodegeneration.Neuron2022
33772540Spinocerebellar Ataxia Type 1 protein Ataxin-1 is signaled to DNA damage by ataxia-telangiectasia mutated kinase.Hum Mol Genet2021
33576571Harnessing the paradoxical phenotypes of APOE É¿2 and APOE É¿4 to identify genetic modifiers in Alzheimer's disease.Alzheimers Dement2021
33871358Downregulation of glial genes involved in synaptic function mitigates Huntington's disease pathogenesis.Elife2021
33709453Dual targeting of brain region-specific kinases potentiates neurological rescue in Spinocerebellar ataxia type 1.EMBO J2021
30753434Cross-species genetic screens to identify kinase targets for APP reduction in Alzheimer's disease.Hum Mol Genet2019
30249792A Druggable Genome Screen Identifies Modifiers of α-Synuclein Levels via a Tiered Cross-Species Validation Approach.J Neurosci2018
29860311PAK1 regulates ATXN1 levels providing an opportunity to modify its toxicity in spinocerebellar ataxia type 1.Hum Mol Genet2018
29936182High-Throughput Functional Analysis Distinguishes Pathogenic, Nonpathogenic, and Compensatory Transcriptional Changes in Neurodegeneration.Cell Syst2018
29256861Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein.Elife2017
26761346Drosophila Mitf regulates the V-ATPase and the lysosomal-autophagic pathway.Autophagy2016
27720485Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model.Neuron2016
27779468TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau.Elife2016
27433942Metal Homeostasis Regulators Suppress FRDA Phenotypes in a Drosophila Model of the Disease.PLoS One2016
27338814Uncoupling neuronal death and dysfunction in Drosophila models of neurodegenerative disease.Acta Neuropathol Commun2016
26900923Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice.Nat Neurosci2016
25738228A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity.Elife2015
26158631TORC1 Inhibition by Rapamycin Promotes Antioxidant Defences in a Drosophila Model of Friedreich's Ataxia.PLoS One2015
26165689Huntingtin proteolysis releases non-polyQ fragments that cause toxicity through dynamin 1 dysregulation.EMBO J2015
25540325Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease.Sci Transl Med2014
23345237Tau loss attenuates neuronal network hyperexcitability in mouse and Drosophila genetic models of epilepsy.J Neurosci2013
23637619Smaug/SAMD4A restores translational activity of CUGBP1 and suppresses CUG-induced myopathy.PLoS Genet2013
23719381RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1.Nature2013
23525043Identification of NUB1 as a suppressor of mutant Huntington toxicity via enhanced protein clearance.Nat Neurosci2013
22511757Inhibition of lipid signaling enzyme diacylglycerol kinase epsilon attenuates mutant huntingtin toxicity.J Biol Chem2012
23209424A genome-scale RNA-interference screen identifies RRAS signaling as a pathologic feature of Huntington's disease.PLoS Genet2012
22794259Network organization of the huntingtin proteomic interactome in mammalian brain.Neuron2012
20670829Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease.Neuron2010
18184562Suppression of neurodegeneration and increased neurotransmission caused by expanded full-length huntingtin accumulating in the cytoplasm.Neuron2008
18842880The Drosophila FMRP and LARK RNA-binding proteins function together to regulate eye development and circadian behavior.J Neurosci2008
18773074Genetic modifiers of MeCP2 function in Drosophila.PLoS Genet2008
17984172Comparative analysis of genetic modifiers in Drosophila points to common and distinct mechanisms of pathogenesis among polyglutamine diseases.Hum Mol Genet2008
17460691Drosophila researchers focus on human disease.Nat Genet2007
18166084dAtaxin-2 mediates expanded Ataxin-1-induced neurodegeneration in a Drosophila model of SCA1.PLoS Genet2007
17635840Argonaute-2-dependent rescue of a Drosophila model of FXTAS by FRAXE premutation repeat.Hum Mol Genet2007
17698010RNA-binding proteins hnRNP A2/B1 and CUGBP1 suppress fragile X CGG premutation repeat-induced neurodegeneration in a Drosophila model of FXTAS.Neuron2007
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Collaborators

Zhandong Liu
Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital
Co-authored papers 8
Diego E Rincon-Limas
University of Florida
Co-authored papers 8
Joshua M Shulman
Baylor College of Medicine
Co-authored papers 6
Lisa M Ellerby
Buck Institute for Research on Aging
Co-authored papers 4
Hugo J Bellen
Baylor College of Medicine
Co-authored papers 4
Genevera I Allen
Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital
Co-authored papers 3
David L Nelson
Baylor College of Medicine
Co-authored papers 3
Olivier Lichtarge
Baylor College of Medicine
Co-authored papers 3
Thomas Bourquard
Co-authored papers 2
Peng Jin
Co-authored papers 2
Juan Carlos Izpisua Belmonte
Inc., Salk Institute for Biological Studies
Co-authored papers 2
Young-Won Kim
Baylor College of Medicine
Co-authored papers 2
Steve Horvath
David Geffen School of Medicine, University of California los angeles
Co-authored papers 2
Juan C Troncoso
Co-authored papers 2
Giovanni Coppola
David Geffen School of Medicine, University of California los angeles
Co-authored papers 2
Ying-Wooi Wan
Baylor College of Medicine
Co-authored papers 2
Ileana M Cristea
Princeton University
Co-authored papers 1
Adrienne M Wang
Co-authored papers 1
Reed A George
Howard Hughes Medical Institute
Co-authored papers 1
Sudhir Sahasrabudhe
University of Medicine and Dentistry of New Jersey, New Jersey Medical School
Co-authored papers 1
Pieter J de Jong
Center for Genetics, Children's Hospital Oakland Research Institute
Co-authored papers 1
Bradford W Gibson
The Buck Institute for Research on Aging
Co-authored papers 1
Leslie M Thompson
Co-authored papers 1
Susan E Celniker
Lawrence Berkeley National Laboratory
Co-authored papers 1
Ryan G Lim
Co-authored papers 1
Russell Bell
Huntsman Cancer Institute at the University of Utah
Co-authored papers 1
Kaylyn Devlin
Co-authored papers 1
Rami Al-Ouran
Baylor College of Medicine
Co-authored papers 1
David Kilburn
Co-authored papers 1
Tiemo J Klisch
Co-authored papers 1
Release 1.2