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Author Details

David B Weiner
Wistar Institute
1986
515
81
PMIDPaper TitleJournal TitlePublished Year
36728420Siglec-9 Restrains Antibody-Dependent Natural Killer Cell Cytotoxicity against SARS-CoV-2.mBio2023
37341186Irreversible Inactivation of SARS-CoV-2 by Lectin Engagement with Two Glycan Clusters on the Spike Protein.Biochemistry2023
37265268Delivery platforms for broadly neutralizing antibodies.Curr Opin HIV AIDS2023
36999023Adenosine deaminase augments SARS-CoV-2 specific cellular and humoral responses in aged mouse models of immunization and challenge.Front Immunol2023
36915911Multivalent <i>in vivo</i> delivery of DNA-encoded bispecific T cell engagers effectively controls heterogeneous GBM tumors and mitigates immune escape.Mol Ther Oncolytics2023
36807845Gene-encoded nanoparticle vaccine platforms for in vivo assembly of multimeric antigen to promote adaptive immunity.Wiley Interdiscip Rev Nanomed Nanobiotechnol2023
36911698Engineered antibody cytokine chimera synergizes with DNA-launched nanoparticle vaccines to potentiate melanoma suppression <i>in vivo</i>.Front Immunol2023
36534786Phase I Trial of a Therapeutic DNA Vaccine for Preventing Hepatocellular Carcinoma from Chronic Hepatitis C Virus (HCV) Infection.Cancer Prev Res (Phila)2023
34774754Debulking SARS-CoV-2 in saliva using angiotensin converting enzyme 2 in chewing gum to decrease oral virus transmission and infection.Mol Ther2022
35839767Mucosal chemokine adjuvant enhances synDNA vaccine-mediated responses to SARS-CoV-2 and provides heterologous protection in vivo.Cell Rep Med2022
35428500Prime-boost vaccination regimens with INO-4800 and INO-4802 augment and broaden immune responses against SARS-CoV-2 in nonhuman primates.Vaccine2022
35750334Improved Durability to SARS-CoV-2 Vaccine Immunity following Coimmunization with Molecular Adjuvant Adenosine Deaminase-1.J Immunol2022
35619703Transcriptome and TCR Repertoire Measurements of CXCR3<sup>+</sup> T Follicular Helper Cells Within HIV-Infected Human Lymph Nodes.Front Immunol2022
35588060Cross-reactive antibodies facilitate innate sensing of dengue and Zika viruses.JCI Insight2022
36509287A mAb against surface-expressed FSHR engineered to engage adaptive immunity for ovarian cancer immunotherapy.JCI Insight2022
35995959Engineered DNA-encoded monoclonal antibodies targeting Plasmodium falciparum circumsporozoite protein confer single dose protection in a murine malaria challenge model.Sci Rep2022
36202799DNA-delivered antibody cocktail exhibits improved pharmacokinetics and confers prophylactic protection against SARS-CoV-2.Nat Commun2022
36090479<i>In vivo</i> DNA-launched bispecific T cell engager targeting IL-13Rα2 controls tumor growth in an animal model of glioblastoma multiforme.Mol Ther Oncolytics2022
35121758Induction of tier-2 neutralizing antibodies in mice with a DNA-encoded HIV envelope native like trimer.Nat Commun2022
35090597Nucleic acid delivery of immune-focused SARS-CoV-2 nanoparticles drives rapid and potent immunogenicity capable of single-dose protection.Cell Rep2022
35061975Comparison of Wild Type DNA Sequence of Spike Protein from SARS-CoV-2 with Optimized Sequence on The Induction of Protective Responses Against SARS-Cov-2 Challenge in Mouse Model.Hum Vaccin Immunother2022
35079784SARS-CoV-2 DNA Vaccine INO-4800 Induces Durable Immune Responses Capable of Being Boosted in a Phase 1 Open-Label Trial.J Infect Dis2022
33175656Durability of response to VGX-3100 treatment of HPV16/18 positive cervical HSIL.Hum Vaccin Immunother2021
33673603Multivalent DNA Vaccines as A Strategy to Combat Multiple Concurrent Epidemics: Mosquito-Borne and Hemorrhagic Fever Viruses.Viruses2021
33727348Synthetic DNA Delivery of an Optimized and Engineered Monoclonal Antibody Provides Rapid and Prolonged Protection against Experimental Gonococcal Infection.mBio2021
33886507Intradermal delivery of a synthetic DNA vaccine protects macaques from Middle East respiratory syndrome coronavirus.JCI Insight2021
33884106Immunotherapy of prostate cancer using novel synthetic DNA vaccines targeting multiple tumor antigens.Genes Cancer2021
35071745DNA immunotherapy targeting BARF1 induces potent anti-tumor responses against Epstein-Barr-virus-associated carcinomas.Mol Ther Oncolytics2021
34762717Siglec-9 defines and restrains a natural killer subpopulation highly cytotoxic to HIV-infected cells.PLoS Pathog2021
34525286Safety and Immunogenicity of an Anti-Zika Virus DNA Vaccine.N Engl J Med2021
34604818Intradermal-delivered DNA vaccine induces durable immunity mediating a reduction in viral load in a rhesus macaque SARS-CoV-2 challenge model.Cell Rep Med2021
34650089INO-4800 DNA vaccine induces neutralizing antibodies and T cell activity against global SARS-CoV-2 variants.NPJ Vaccines2021
34152830Strategic Variants of CSP Delivered as SynDNA Vaccines Demonstrate Heterogeneity of Immunogenicity and Protection from <i>Plasmodium</i> Infection in a Murine Model.Infect Immun2021
34098736Erratum for Adeniji et al., "COVID-19 Severity Is Associated with Differential Antibody Fc-Mediated Innate Immune Functions".mBio2021
34124612A novel mouse AAV6 hACE2 transduction model of wild-type SARS-CoV-2 infection studied using synDNA immunogens.iScience2021
34141866A synDNA vaccine delivering neoAg collections controls heterogenous, multifocal murine lung and ovarian tumors via robust T cell generation.Mol Ther Oncolytics2021
34230114Phase 1 study of safety, tolerability and immunogenicity of the human telomerase (hTERT)-encoded DNA plasmids INO-1400 and INO-1401 with or without IL-12 DNA plasmid INO-9012 in adult patients with solid tumors.J Immunother Cancer2021
33436641Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy.Nat Commun2021
33392485Safety and immunogenicity of INO-4800 DNA vaccine against SARS-CoV-2: A preliminary report of an open-label, Phase 1 clinical trial.EClinicalMedicine2021
32157600In Vivo Delivery of Nucleic Acid-Encoded Monoclonal Antibodies.BioDrugs2020
35047878Harnessing Recent Advances in Synthetic DNA and Electroporation Technologies for Rapid Vaccine Development Against COVID-19 and Other Emerging Infectious Diseases.Front Med Technol2020
32088322IFNL3-adjuvanted HCV DNA vaccine reduces regulatory T cell frequency and increases virus-specific T cell responses.J Hepatol2020
31936739Synthetic DNA Vaccines Adjuvanted with pIL-33 Drive Liver-Localized T Cells and Provide Protection from <i>Plasmodium</i> Challenge in a Mouse Model.Vaccines (Basel)2020
32057572CCR10 expression is required for the adjuvant activity of the mucosal chemokine CCL28 when delivered in the context of an HIV-1 Env DNA vaccine.Vaccine2020
31697648In vivo delivery of synthetic DNA-encoded antibodies induces broad HIV-1-neutralizing activity.J Clin Invest2020
31659752Vaccine innovations for emerging infectious diseases-a symposium report.Ann N Y Acad Sci2020
32013270Immune Therapy Targeting E6/E7 Oncogenes of Human Paillomavirus Type 6 (HPV-6) Reduces or Eliminates the Need for Surgical Intervention in the Treatment of HPV-6 Associated Recurrent Respiratory Papillomatosis.Vaccines (Basel)2020
31799896Synthetic nucleic acid antibody prophylaxis confers rapid and durable protective immunity against Zika virus challenge.Hum Vaccin Immunother2020
33297341Intramuscular and Intradermal Electroporation of HIV-1 PENNVAX-GP<sup>®</sup> DNA Vaccine and IL-12 Is Safe, Tolerable, Acceptable in Healthy Adults.Vaccines (Basel)2020
33119599A novel synthetic DNA vaccine elicits protective immune responses against Powassan virus.PLoS Negl Trop Dis2020
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Collaborators

Michele A Kutzler
Drexel University College of Medicine
Co-authored papers 29
Gary P Kobinger
University of Texas Medical Branch
Co-authored papers 20
Pablo Tebas
Perelman School of Medicine, University of Pennsylvania
Co-authored papers 15
Ruxandra Draghia-Akli
The Janssen Pharmaceutical Companies of Johnson & Johnson
Co-authored papers 12
Luis J Montaner
Wistar Institute
Co-authored papers 11
Anthony Tsai
Co-authored papers 9
David C Montefiori
Co-authored papers 7
Anne S De Groot
University of Georgia
Co-authored papers 5
Jeffrey N Myers
The University of Texas MD Anderson Cancer Center
Co-authored papers 4
Opeyemi S Adeniji
The Wistar Institute
Co-authored papers 4
Andrew V Kossenkov
The Wistar Institute
Co-authored papers 4
Rafick-Pierre Sekaly
Pathology Advanced Translational Research Unit, Emory University School of Medicine
Co-authored papers 3
Patrice A Frost
Southwest National Primate Research Center
Co-authored papers 3
William D Martin
EpiVax Inc.
Co-authored papers 3
Jeffrey M Jacobson
Co-authored papers 3
Daniel Rivera
Center for Natural Products Research, University of Havana
Co-authored papers 3
Jinhee Lee
University of Massachusetts Medical School
Co-authored papers 2
Ronald G Collman
University of Pennsylvania School of Medicine
Co-authored papers 2
Michael C Keefer
MK University of Rochester
Co-authored papers 2
Viraj Kulkarni
Texas Biomedical Research Institute
Co-authored papers 2
Kimberly Meade-White
National Institutes of Allergy and Infectious Disease, National Institutes of Health
Co-authored papers 2
James E Crowe
Vanderbilt University Medical Center
Co-authored papers 2
Robert F Siliciano
Johns Hopkins University School of Medicine
Co-authored papers 2
Kenneth B Margulies
Perelman School of Medicine at the University of Pennsylvania
Co-authored papers 2
Ken Kazahaya
Co-authored papers 2
David H O'Connor
Co-authored papers 2
David Heckerman
Co-authored papers 2
Luisa Marcon
Dana-Farber Cancer Institute, Harvard Medical School
Co-authored papers 2
Julie A McMurry
University of Colorado - Anschutz Medical Campus
Co-authored papers 2
Bonaventura Clotet
IrsiCaixa AIDS Research Institute, Hospital Universitari Germans Trias i Pujol
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