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Author Details

Rama Khokha
Princess Margaret Cancer Centre, University Health Network
1984
172
75
PMIDPaper TitleJournal TitlePublished Year
36927977Systemic inflammatory prognostic scores in advanced pancreatic adenocarcinoma.Br J Cancer2023
37847590Differential DNA damage repair and PARP inhibitor vulnerability of the mammary epithelial lineages.Cell Rep2023
37883228Differential DNA damage repair and PARP inhibitor vulnerability of the mammary epithelial lineages.Cell Rep2023
37768107Hourglass, a rapid analysis framework for heterogeneous bioimaging data, identifies sex disparity in IL-6/STAT3-associated immune phenotypes in pancreatic cancer.J Pathol2023
35139353Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity.Immunity2022
35694787Correction: GATA6 Expression Distinguishes Classical and Basal-like Subtypes in Advanced Pancreatic Cancer.Clin Cancer Res2022
35393420Modification of BRCA1-associated breast cancer risk by HMMR overexpression.Nat Commun2022
35981243Glycoproteomics Identifies Plexin-B3 as a Targetable Cell Surface Protein Required for the Growth and Invasion of Triple-Negative Breast Cancer Cells.J Proteome Res2022
36006427Correlation of transcriptional subtypes with a validated CT radiomics score in resectable pancreatic ductal adenocarcinoma.Eur Radiol2022
34196309Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis.J Clin Invest2021
34500457Abnormal B-cell development in TIMP-deficient bone marrow.Blood Adv2021
34644529Spatially confined sub-tumor microenvironments in pancreatic cancer.Cell2021
34533565TIMP1 expression underlies sex disparity in liver metastasis and survival in pancreatic cancer.J Exp Med2021
34031589Mammary epithelial cells have lineage-rooted metabolic identities.Nat Metab2021
32156747GATA6 Expression Distinguishes Classical and Basal-like Subtypes in Advanced Pancreatic Cancer.Clin Cancer Res2020
31964786A Four-Chemokine Signature Is Associated with a T-cell-Inflamed Phenotype in Primary and Metastatic Pancreatic Cancer.Clin Cancer Res2020
32094913Author Correction: Human somatic cell mutagenesis creates genetically tractable sarcomas.Nat Genet2020
31123716Identifying the murine mammary cell target of metformin exposure.Commun Biol2019
31645297Metalloproteases: On the Watch in the Hematopoietic Niche.Trends Immunol2019
30216540TIMP Loss Activates Metalloproteinase-TNFα-DKK1 Axis To Compromise Wnt Signaling and Bone Mass.J Bone Miner Res2019
30093633Cross-species genomics identifies DLG2 as a tumor suppressor in osteosarcoma.Oncogene2019
31267556Mammary stem cells and progenitors: targeting the roots of breast cancer for prevention.EMBO J2019
31371388Metalloprotease inhibitor TIMP proteins control FGF-2 bioavailability and regulate skeletal growth.J Cell Biol2019
30988300PDGFRα<sup>+</sup> stromal adipocyte progenitors transition into epithelial cells during lobulo-alveologenesis in the murine mammary gland.Nat Commun2019
29610525CDH4 is a novel determinant of osteosarcoma tumorigenesis and metastasis.Oncogene2018
30222135Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis.J Clin Invest2018
29921600Mammary molecular portraits reveal lineage-specific features and progenitor cell vulnerabilities.J Cell Biol2018
30271991Proliferative heterogeneity of murine epithelial cells in the adult mammary gland.Commun Biol2018
27270422MiR-26a inhibits stem cell-like phenotype and tumor growth of osteosarcoma by targeting Jagged1.Oncogene2017
28482323Planarians as models of cadmium-induced neoplasia provide measurable benchmarks for mechanistic studies.Ecotoxicol Environ Saf2017
28578911Metalloproteinases in extracellular vesicles.Biochim Biophys Acta Mol Cell Res2017
27932800TIMPs: versatile extracellular regulators in cancer.Nat Rev Cancer2017
27314104Tumor suppression by stromal TIMPs.Mol Cell Oncol2016
27241552RANKL/RANK control Brca1 mutation- .Cell Res2016
24662820PKA signaling drives mammary tumorigenesis through Src.Oncogene2015
28447939A Progesterone-CXCR4 Axis Controls Mammary Progenitor Cell Fate in the Adult Gland.Stem Cell Reports2015
26659571RANKL blockade prevents and treats aggressive osteosarcomas.Sci Transl Med2015
26332574Timp3 loss accelerates tumour invasion and increases prostate inflammation in a mouse model of prostate cancer.Prostate2015
26448288Progesterone and Synthetic Progestin Controversies--Reply.JAMA Oncol2015
26181171Progesterone Exposure and Breast Cancer Risk: Understanding the Biological Roots.JAMA Oncol2015
26095608RANK Signaling Amplifies WNT-Responsive Mammary Progenitors through R-SPONDIN1.Stem Cell Reports2015
25961939A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis.Nat Genet2015
25706237Expansion of stem cells counteracts age-related mammary regression in compound Timp1/Timp3 null mice.Nat Cell Biol2015
25620030Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression.Cancer Cell2015
25807548Timp3 deficient mice show resistance to developing breast cancer.PLoS One2015
25347747TIMP3 controls cell fate to confer hepatocellular carcinoma resistance.Oncogene2015
24480641Fully interlocking: a story of teamwork among breast epithelial cells.Dev Cell2014
25150980Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state.Nat Cell Biol2014
24802970High CD49f expression is associated with osteosarcoma tumor progression: a study using patient-derived primary cell cultures.Cancer Med2014
23299479Intravitreal injection of TIMP3 or the EGFR inhibitor erlotinib offers protection from oxygen-induced retinopathy in mice.Invest Ophthalmol Vis Sci2013
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Collaborators

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Princess Margaret Cancer Centre/University Health Network
Co-authored papers 25
Otto Sanchez
Ontario Tech University
Co-authored papers 24
Purna A Joshi
Princess Margaret Cancer Centre
Co-authored papers 14
Hui Fang
Beihua University
Co-authored papers 12
Hal K Berman
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 11
Hartland W Jackson
Lunenfeld-Tanenbaum Research Institute
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Tak W Mak
Princess Margaret Cancer Centre, University Health Network
Co-authored papers 10
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Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto
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Thomas Kislinger
Princess Margaret Cancer Centre, University Health Network, University of Toronto
Co-authored papers 8
Pirashaanthy Tharmapalan
Princess Margaret Cancer Centre, University Health Network, University of Toronto
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Trevor D McKee
University Health Network
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Gun Ho Jang
Ontario Institute for Cancer Research
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Razqallah Hakem
Princess Margaret Cancer Centre, University Health Network, University of Toronto
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Yang Shao
Nanjing Geneseeq Technology Inc.
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Ming-Sound Tsao
University Health Network, University of Toronto
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Julie M Wilson
Ontario Institute for Cancer Research
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Alexander G Beristain
BC Children's Hospital Research Institute
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Andrew Wakeham
Princess Margaret Cancer Centre, Ontario Cancer Institute, University Health Network
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Alison E Casey
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Jennifer Cruickshank
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Faiyaz Notta
2Ontario Institute for Cancer Research
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Robert E Denroche
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Anne Hakem
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David W Cescon
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Release 1.2