Author details

Full Name

David J Lefer

Affiliation

ORCID

Career Start Year

1980

Papers

263

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36602878	Insulin-like growth factor 1 reduces coronary atherosclerosis in pigs with familial hypercholesterolemia.		2023
37719422	sGC Stimulation Saves the Diabetic Heart: Red Blood Cells to the Rescue.		2023
36575984	Hydrogen Sulfide Modulates Endothelial-Mesenchymal Transition in Heart Failure.		2023
36752224	Combination Sodium Nitrite and Hydralazine Therapy Attenuates Heart Failure With Preserved Ejection Fraction Severity in a "2-Hit" Murine Model.		2023
36690137	Dietary nitrate biochemistry and physiology. An update on clinical benefits and mechanisms of action.		2023
36519539	Soluble urokinase plasminogen activator receptor: from biomarker to active participant in atherosclerosis and cardiovascular disease.		2022
35701874	Mitochondrial HS Regulates BCAA Catabolism in Heart Failure.	Circulation Research	2022
35743153	Serum Metabolomics Reveals Distinct Profiles during Ischemia and Reperfusion in a Porcine Model of Myocardial Ischemia-Reperfusion.	International Journal of Molecular Sciences	2022
35678315	Alpha7 nicotinic acetylcholine receptor mediates chronic nicotine inhalation-induced cardiopulmonary dysfunction.	Clinical Science	2022
35861740	Leveraging Adipocyte-Cardiomyocyte Signaling to Treat Ischemic Heart Failure.	Circulation Research	2022
33074771	Renal Denervation to Treat Heart Failure.	Annual Review of Physiology	2021
33808673	Hydrogen Sulfide as a Potential Therapy for Heart Failure-Past, Present, and Future.	Antioxidants	2021
33997525	Reply: Tolerating Large Preclinical Models of HFpEF But Without the Intolerance?	JACC: Basic to Translational Science	2021
33665515	Novel GÃ¶ttingen Miniswine Model of HeartÂ Failure With Preserved EjectionÂ Fraction Integrating MultipleÂ Comorbidities.	JACC Basic Transl Sci	2021
33600232	Demystifying Cardiac Aging: Still Much to Learn.	Circulation Research	2021
32760857	Efficacy of a Novel Mitochondrial-Derived Peptide in a Porcine Model of Myocardial Ischemia/Reperfusion Injury.	JACC: Basic to Translational Science	2020
32027885	Cardiovascular phenotype of mice lacking 3-mercaptopyruvate sulfurtransferase.	Biochemical Pharmacology	2020
32004507	Global knockout of ROMK potassium channel worsens cardiac ischemia-reperfusion injury but cardiomyocyte-specific knockout does not: Implications for the identity of mitoKATP.	Journal of Molecular and Cellular Cardiology	2020
31944919	Obstructive Sleep Apnea: The Not-So-Silent Killer.	Circulation Research	2020
32390485	Nonlethal Inhibition of Gut Microbial Trimethylamine N-oxide Production Improves Cardiac Function and Remodeling in a Murine Model of Heart Failure.	Journal of the American Heart Association	2020
32990120	Endothelial Cell Cystathionine Î³-Lyase Expression Level Modulates Exercise Capacity, Vascular Function, and Myocardial Ischemia Reperfusion Injury.	Journal of the American Heart Association	2020
31196459	Renal Denervation Update From theÂ International Sympathetic NervousÂ System Summit: JACC State-of-the-Art Review.	J Am Coll Cardiol	2019
31835893	Exercise Training Promotes Cardiac Hydrogen Sulfide Biosynthesis and Mitigates Pyroptosis to Prevent High-Fat Diet-Induced Diabetic Cardiomyopathy.	Antioxidants	2019
30234368	Redox Pioneer: Professor Hideo Kimura.	Antioxidants and Redox Signaling	2019
30656501	Repeated cell transplantation and adjunct renal denervation in ischemic heart failure: exploring modalities for improving cell therapy efficacy.	Basic Research in Cardiology	2019
31178749	Hydrogen Sulfide Ameliorates Homocysteine-Induced Cardiac Remodeling and Dysfunction.	Frontiers in Physiology	2019
31061006	Update on Gaseous Signaling Molecules Nitric Oxide and Hydrogen Sulfide: Strategies to Capture their Functional Activity for Human Therapeutics.	Molecular Pharmacology	2019
30777693	Effects of a novel hydrogen sulfide prodrug in a porcine model of acute limb ischemia.	Journal of Vascular Surgery	2019
31312764	Cardiometabolic HeartÂ Failure and HFpEF: Still Chasing Unicorns.	JACC Basic Transl Sci	2019
29101177	A novel mtDNA repair fusion protein attenuates maladaptive remodeling and preserves cardiac function in heart failure.	American Journal of Physiology - Heart and Circulatory Physiology	2018
30355137	Evolution of Hydrogen Sulfide Therapeutics to Treat Cardiovascular Disease.	Circulation Research	2018
30384892	Angiotensin Receptor-Neprilysin Inhibitors Emerge as Potential Treatment for Acute Myocardial Infarction.	Journal of the American College of Cardiology	2018
29949382	A novel fibroblast activation inhibitor attenuates left ventricular remodeling and preserves cardiac function in heart failure.	American Journal of Physiology - Heart and Circulatory Physiology	2018
30466519	Renal Denervation Prevents Heart Failure Progression Via Inhibition of the Renin-Angiotensin System.	J Am Coll Cardiol	2018
30623139	Hydrogen Sulfide Attenuates ReninÂ Angiotensin and Aldosterone Pathological Signaling to Preserve KidneyÂ Function and Improve ExerciseÂ Tolerance in Heart Failure.	JACC: Basic to Translational Science	2018
29351451	Guidelines for experimental models of myocardial ischemia and infarction.	Am J Physiol Heart Circ Physiol	2018
29502102	Combined Angiotensin Receptor-Neprilysin Inhibitors Improve Cardiac and Vascular Function Via Increased NO Bioavailability in Heart Failure.	Journal of the American Heart Association	2018
29408195	Hydrogen sulfide regulates cardiac mitochondrial biogenesis via the activation of AMPK.	J Mol Cell Cardiol	2018
27693032	An endovascular model of ischemic myopathy from peripheral arterial disease.	Journal of Vascular Surgery	2017
28674094	Is Cardioprotection Dead?	Circulation	2017
28333381	Protective Actions of H2S in Acute Myocardial Infarction and Heart Failure.	Comprehensive Physiology	2017
28874874	3-Mercaptopyruvate sulfurtransferase produces potential redox regulators cysteine- and glutathione-persulfide (Cys-SSH and GSSH) together with signaling molecules HS, HS and HS.	Scientific Reports	2017
28700817	An Esterase-Sensitive Prodrug Approach for Controllable Delivery of Persulfide Species.	Angewandte Chemie - International Edition	2017
29050562	Renal Sympathetic Denervation ProtectsÂ the Failing Heart Via Inhibition ofÂ NeprilysinÂ Activity in the Kidney.	Journal of the American College of Cardiology	2017
28003140	Slow generation of hydrogen sulfide from sulfane sulfurs and NADH models.	Bioorganic and Medicinal Chemistry Letters	2017
27660293	Restoration of Hydrogen Sulfide Production in Diabetic Mice Improves Reparative Function of Bone Marrow Cells.	Circulation	2016
27296507	Radiofrequency Renal Denervation Protects the Ischemic Heart via Inhibition of GRK2 and Increased Nitric Oxide Signaling.	Circulation Research	2016
27385425	Dietary Nitrate and the Epidemiology of Cardiovascular Disease: Report From a National Heart, Lung, and Blood Institute Workshop.	J Am Heart Assoc	2016
26746429	Nebivolol Acts as a S-Nitrosoglutathione Reductase Inhibitor: A New Mechanism of Action.	Journal of Cardiovascular Pharmacology and Therapeutics	2016
27381758	Zofenopril Protects Against Myocardial Ischemia-Reperfusion Injury by Increasing Nitric Oxide and Hydrogen Sulfide Bioavailability.	Journal of the American Heart Association	2016