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Author Details

Timothy R Hughes
University of Toronto
1992
258
89
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36662884A multimorphic mutation in IRF4 causes human autosomal dominant combined immunodeficiency.Sci Immunol2023
37557175Chromatin accessibility in the Drosophila embryo is determined by transcription factor pioneering and enhancer activation.Dev Cell2023
37552984An RFX transcription factor regulates ciliogenesis in the closest living relatives of animals.Curr Biol2023
37150886(+)-Catechin Attenuates Multiple Atherosclerosis-Associated Processes In Vitro, Modulates Disease-Associated Risk Factors in C57BL/6J Mice and Reduces Atherogenesis in LDL Receptor Deficient Mice by Inhibiting Inflammation and Increasing Markers of Plaque Stability.Mol Nutr Food Res2023
37086783Structural insights into DNA recognition by the BEN domain of the transcription factor BANP.J Biol Chem2023
36902113Assessment of Lab4P Probiotic Effects on Cognition in 3xTg-AD Alzheimer's Disease Model Mice and the SH-SY5Y Neuronal Cell Line.Int J Mol Sci2023
36702896A universal deep-learning model for zinc finger design enables transcription factor reprogramming.Nat Biotechnol2023
37002329RNA-binding proteins that lack canonical RNA-binding domains are rarely sequence-specific.Sci Rep2023
36662884A multimorphic mutation in IRF4 causes human autosomal dominant combined immunodeficiency.Sci Immunol2023
37035540Known sequence features explain half of all human gene ends.NAR Genom Bioinform2023
37557175Chromatin accessibility in the Drosophila embryo is determined by transcription factor pioneering and enhancer activation.Dev Cell2023
37552984An RFX transcription factor regulates ciliogenesis in the closest living relatives of animals.Curr Biol2023
37086783Structural insights into DNA recognition by the BEN domain of the transcription factor BANP.J Biol Chem2023
37150886(+)-Catechin Attenuates Multiple Atherosclerosis-Associated Processes In Vitro, Modulates Disease-Associated Risk Factors in C57BL/6J Mice and Reduces Atherogenesis in LDL Receptor Deficient Mice by Inhibiting Inflammation and Increasing Markers of Plaque Stability.Mol Nutr Food Res2023
37035540Known sequence features explain half of all human gene ends.NAR Genom Bioinform2023
37002329RNA-binding proteins that lack canonical RNA-binding domains are rarely sequence-specific.Sci Rep2023
36902113Assessment of Lab4P Probiotic Effects on Cognition in 3xTg-AD Alzheimer's Disease Model Mice and the SH-SY5Y Neuronal Cell Line.Int J Mol Sci2023
36702896A universal deep-learning model for zinc finger design enables transcription factor reprogramming.Nat Biotechnol2023
34543680Complement C3 and C3aR mediate different aspects of emotional behaviours; relevance to risk for psychiatric disorder.Brain Behav Immun2022
36018788PRIESSTESS: interpretable, high-performing models of the sequence and structure preferences of RNA-binding proteins.Nucleic Acids Res2022
36142647Therapeutic Intervention with Anti-Complement Component 5 Antibody Does Not Reduce NASH but Does Attenuate Atherosclerosis and MIF Concentrations in Ldlr-/-.Leiden Mice.Int J Mol Sci2022
35685773The Impact of Probiotic Supplementation on Cognitive, Pathological and Metabolic Markers in a Transgenic Mouse Model of Alzheimer's Disease.Front Neurosci2022
35552404Reconstruction of full-length LINE-1 progenitors from ancestral genomes.Genetics2022
35794654Terminal complement pathway activation drives synaptic loss in Alzheimer's disease models.Acta Neuropathol Commun2022
35476669The X-linked splicing regulator MBNL3 has been co-opted to restrict placental growth in eutherians.PLoS Biol2022
35914531Regulation of alternative polyadenylation by the C2H2-zinc-finger protein Sp1.Mol Cell2022
35144965Distinct structural bases for sequence-specific DNA binding by mammalian BEN domain proteins.Genes Dev2022
34543680Complement C3 and C3aR mediate different aspects of emotional behaviours; relevance to risk for psychiatric disorder.Brain Behav Immun2022
35476669The X-linked splicing regulator MBNL3 has been co-opted to restrict placental growth in eutherians.PLoS Biol2022
35794654Terminal complement pathway activation drives synaptic loss in Alzheimer's disease models.Acta Neuropathol Commun2022
35685773The Impact of Probiotic Supplementation on Cognitive, Pathological and Metabolic Markers in a Transgenic Mouse Model of Alzheimer's Disease.Front Neurosci2022
35552404Reconstruction of full-length LINE-1 progenitors from ancestral genomes.Genetics2022
36142647Therapeutic Intervention with Anti-Complement Component 5 Antibody Does Not Reduce NASH but Does Attenuate Atherosclerosis and MIF Concentrations in Ldlr-/-.Leiden Mice.Int J Mol Sci2022
36018788PRIESSTESS: interpretable, high-performing models of the sequence and structure preferences of RNA-binding proteins.Nucleic Acids Res2022
35914531Regulation of alternative polyadenylation by the C2H2-zinc-finger protein Sp1.Mol Cell2022
35144965Distinct structural bases for sequence-specific DNA binding by mammalian BEN domain proteins.Genes Dev2022
34216185The Lab4P Consortium of Probiotics Attenuates Atherosclerosis in LDL Receptor Deficient Mice Fed a High Fat Diet and Causes Plaque Stabilization by Inhibiting Inflammation and Several Pro-Atherogenic Processes.Mol Nutr Food Res2021
34216185The Lab4P Consortium of Probiotics Attenuates Atherosclerosis in LDL Receptor Deficient Mice Fed a High Fat Diet and Causes Plaque Stabilization by Inhibiting Inflammation and Several Pro-Atherogenic Processes.Mol Nutr Food Res2021
34104882Known sequence features can explain half of all human gene ends.NAR Genom Bioinform2021
33561217Diverse Eukaryotic CGG-Binding Proteins Produced by Independent Domestications of hAT Transposons.Mol Biol Evol2021
33764850Probiotics reduce self-reported symptoms of upper respiratory tract infection in overweight and obese adults: should we be considering probiotics during viral pandemics?Gut Microbes2021
33556623Crystal structure of the BRPF2 PWWP domain in complex with DNA reveals a different binding mode than the HDGF family of PWWP domains.Biochim Biophys Acta Gene Regul Mech2021
34569651Pro-atherogenic actions of signal transducer and activator of transcription 1 serine 727 phosphorylation in LDL receptor deficient mice via modulation of plaque inflammation.FASEB J2021
34620190Global properties of regulatory sequences are predicted by transcription factor recognition mechanisms.Genome Biol2021
34391865A genome guided evaluation of the Lab4 probiotic consortium.Genomics2021
34901123The Impact of Lab4 Probiotic Supplementation in a 90-Day Study in Wistar Rats.Front Nutr2021
33764850Probiotics reduce self-reported symptoms of upper respiratory tract infection in overweight and obese adults: should we be considering probiotics during viral pandemics?Gut Microbes2021
33561217Diverse Eukaryotic CGG-Binding Proteins Produced by Independent Domestications of hAT Transposons.Mol Biol Evol2021
33556623Crystal structure of the BRPF2 PWWP domain in complex with DNA reveals a different binding mode than the HDGF family of PWWP domains.Biochim Biophys Acta Gene Regul Mech2021
34901123The Impact of Lab4 Probiotic Supplementation in a 90-Day Study in Wistar Rats.Front Nutr2021
  • 1 - 50 of 516

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Collaborators

Quaid Morris
Sloan Kettering Institute
Co-authored papers 49
Ally Yang
University of Toronto
Co-authored papers 26
Jack F Greenblatt
College Street, University of Toronto
Co-authored papers 24
Debashish Ray
Co-authored papers 23
Benjamin J Blencowe
University of Toronto
Co-authored papers 22
Matthew T Weirauch
University of Cincinnati College of Medicine
Co-authored papers 21
Brendan J Frey
University of Toronto
Co-authored papers 17
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 16
Sanie Mnaimneh
University of Toronto
Co-authored papers 15
Charles Boone
University of Toronto
Co-authored papers 14
Gordon Chua
University of Calgary
Co-authored papers 14
Tomas Babak
Queen's University
Co-authored papers 14
Harm van Bakel
Icahn School of Medicine at Mount Sinai
Co-authored papers 12
Wen Zhang
Nanjing Agricultural University
Co-authored papers 12
Mark D Robinson
University of Zurich
Co-authored papers 12
Andrew Emili
Boston University School of Medicine, Boston University
Co-authored papers 11
Shawna L Hiley
University of Toronto College Street
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Naveed Mohammad
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
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Qun Pan
University of Toronto
Co-authored papers 7
Brenda J Andrews
University of Toronto
Co-authored papers 7
J??rg Grigull
York University
Co-authored papers 6
Dawn P Richards
Canadian Arthritis Patient Alliance and Five02 Labs Inc.
Co-authored papers 6
Christopher J Roberts
School of Pharmacy, University of Nottingham
Co-authored papers 6
Jussi Taipale
Co-authored papers 6
Veronica Canadien
Hospital for Sick Children
Co-authored papers 6
Armaity P Davierwala
Max Planck Institute for Evolutionary Anthropology
Co-authored papers 6
Wen-Tao Peng
West China Second University Hospital, Sichuan University
Co-authored papers 6
Michael F Berger
Co-authored papers 6
Renee L Brost
Cubist Pharmaceuticals, Inc.
Co-authored papers 6
Jeff Pootoolal
Antimicrobial Research Centre, McMaster University
Co-authored papers 6
Release 1.2