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Author Details

Fran Supek
Catalan Institution for Research and Advanced Studies (ICREA)
1992
57
27
PMIDPaper TitleJournal TitlePublished Year
36346689NBN Pathogenic Germline Variants are Associated with Pan-Cancer Susceptibility and In Vitro DNA Damage Response Defects.Clin Cancer Res2023
37673928Author Correction: The impact of rare germline variants on human somatic mutation processes.Nat Commun2023
37095494Prevalence, causes and impact of TP53-loss phenocopying events in human tumors.BMC Biol2023
37328655Proton and alpha radiation-induced mutational profiles in human cells.Sci Rep2023
35274136Spectrum of DNA mismatch repair failures viewed through the lens of cancer genomics and implications for therapy.Clin Sci (Lond)2022
35614096Mutational signatures are markers of drug sensitivity of cancer cells.Nat Commun2022
35927263TP53-dependent toxicity of CRISPR/Cas9 cuts is differential across genomic loci and can confound genetic screening.Nat Commun2022
35015788A framework for mutational signature analysis based on DNA shape parameters.PLoS One2022
33277042To NMD or Not To NMD: Nonsense-Mediated mRNA Decay in Cancer and Other Genetic Diseases.Trends Genet2021
33788831Loss of the abasic site sensor HMCES is synthetic lethal with the activity of the APOBEC3A cytosine deaminase in cancer cells.PLoS Biol2021
34862370Higher order genetic interactions switch cancer genes from two-hit to one-hit drivers.Nat Commun2021
32503990A synthesis of bacterial and archaeal phenotypic trait data.Sci Data2020
32747826DNA mismatch repair promotes APOBEC3-mediated diffuse hypermutation in human cancers.Nat Genet2020
32937430Matching cell lines with cancer type and subtype of origin via mutational, epigenomic, and transcriptomic patterns.Sci Adv2020
30986244Passenger mutations accurately classify human tumors.PLoS Comput Biol2019
31863070Patterns of diverse gene functions in genomic neighborhoods predict gene function and phenotype.Sci Rep2019
31744546The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens.Genome Biol2019
31659324The impact of nonsense-mediated mRNA decay on genetic disease, gene editing and cancer immunotherapy.Nat Genet2019
31849330Whole genome DNA sequencing provides an atlas of somatic mutagenesis in healthy human cells and identifies a tumor-prone cell type.Genome Biol2019
31307927Scales and mechanisms of somatic mutation rate variation across the human genome.DNA Repair (Amst)2019
29407988Machine learning prioritizes synthesis of primaquine ureidoamides with high antimalarial activity and attenuated cytotoxicity.Eur J Med Chem2018
29973584Systematic discovery of germline cancer predisposition genes through the identification of somatic second hits.Nat Commun2018
29991352The evolutionary signal in metagenome phyletic profiles predicts many gene functions.Microbiome2018
30455462Loss of G9a preserves mutation patterns but increases chromatin accessibility, genomic instability and aggressiveness in skin tumours.Nat Cell Biol2018
27812945Visualizing GO Annotations.Methods Mol Biol2017
28188144Elevated Rate of Genome Rearrangements in Radiation-Resistant Bacteria.Genetics2017
28753428Clustered Mutation Signatures Reveal that Error-Prone DNA Repair Targets Mutations to Active Genes.Cell2017
27522084Extensive complementarity between gene function prediction methods.Bioinformatics2016
26538122The Code of Silence: Widespread Associations Between Synonymous Codon Biases and Gene Function.J Mol Evol2016
27618451The rules and impact of nonsense-mediated mRNA decay in human cancers.Nat Genet2016
27604469An expanded evaluation of protein function prediction methods shows an improvement in accuracy.Genome Biol2016
27915291The landscape of microbial phenotypic traits and associated genes.Nucleic Acids Res2016
27333808MUFFINN: cancer gene discovery via network analysis of somatic mutation data.Genome Biol2016
25707793Differential DNA mismatch repair underlies mutation rate variation across the human genome.Nature2015
25971281Global Shifts in Genome and Proteome Composition Are Very Tightly Coupled.Genome Biol Evol2015
24630730Synonymous mutations frequently act as driver mutations in human cancers.Cell2014
25211471Hydroxymethylated cytosines are associated with elevated C to G transversion rates.PLoS Genet2014
24882003Signatures of conformational stability and oxidation resistance in proteomes of pathogenic bacteria.Cell Rep2014
24580753Inferring gene function from evolutionary change in signatures of translation efficiency.Genome Biol2014
23353650A large-scale evaluation of computational protein function prediction.Nat Methods2013
23772653Accurate models for P-gp drug recognition induced from a cancer cell line cytotoxicity screen.J Med Chem2013
23308060Phyletic profiling with cliques of orthologs is enhanced by signatures of paralogy relationships.PLoS Comput Biol2013
21046426Putative mechanisms of antitumor activity of cyano-substituted heteroaryles in HeLa cells.Invest New Drugs2012
23284284Nucleoid-associated proteins affect mutation dynamics in E. coli in a growth phase-specific manner.PLoS Comput Biol2012
21269423Proteome sequence features carry signatures of the environmental niche of prokaryotes.BMC Evol Biol2011
21789182REVIGO summarizes and visualizes long lists of gene ontology terms.PLoS One2011
21628081Could LogP be a principal determinant of biological activity in 18-crown-6 ethers? Synthesis of biologically active adamantane-substituted diaza-crowns.Eur J Med Chem2011
19639251Computational structure-activity study directs synthesis of novel antitumor enkephalin analogs.Amino Acids2010
20585573Translational selection is ubiquitous in prokaryotes.PLoS Genet2010
20421604On relevance of codon usage to expression of synthetic and natural genes in Escherichia coli.Genetics2010
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Collaborators

Tomislav ??muc
Ruder Boskovic Institute
Co-authored papers 18
Nives ??kunca
ETH Zurich, Universitatstrasse 19
Co-authored papers 6
Sa??o D??eroski
Jozef Stefan Institute
Co-authored papers 4
Vedrana Vidulin
University College London
Co-authored papers 4
Prajwal Bhat
Royal Holloway University of London
Co-authored papers 3
Mark N Wass
University of Kent
Co-authored papers 3
Alberto Paccanaro
University of London
Co-authored papers 3
Julian Gough
Medical Research Council Laboratory of Molecular Biology
Co-authored papers 3
Christine Orengo
University College London, Institute of Structural and Molecular Biology
Co-authored papers 3
Jianlin Cheng
University of Missouri
Co-authored papers 3
Marco Falda
University of Padova
Co-authored papers 3
Alfonso E Romero
University of Miami
Co-authored papers 3
Enrico Lavezzo
University of Padova
Co-authored papers 3
Paolo Fontana
San Pio Hospital
Co-authored papers 3
Predrag Radivojac
Indiana University
Co-authored papers 3
Haixuan Yang
University of Galway
Co-authored papers 3
Sean D Mooney
University of Washington
Co-authored papers 3
Hai Fang
University of Bristol
Co-authored papers 3
Stefano Toppo
University of Padova
Co-authored papers 3
Patricia C Babbitt
University of California san francisco
Co-authored papers 3
Asa Ben-Hur
Colorado State University
Co-authored papers 3
Michal Linial
Institute of Life Sciences, The Hebrew University of Jerusalem
Co-authored papers 3
Toni Gabald??n
Catalan Institution for Research and Advanced Studies
Co-authored papers 3
Daisuke Kihara
Purdue University
Co-authored papers 3
Iddo Friedberg
Iowa State University
Co-authored papers 3
David T Jones
University College London
Co-authored papers 3
Steven E Brenner
University of California berkeley
Co-authored papers 3
Rita Casadio
Department of Pharmacy and Biotechnology, University of Bologna
Co-authored papers 3
Burkhard Rost
Technical University of Munich (TUM)
Co-authored papers 3
Domenico Cozzetto
Imperial College London
Co-authored papers 3
Release 1.2