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Author Details

Wenwei Lin
St. Jude Children's Research Hospital
2007
88
30
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
38084912A bromodomain-independent mechanism of gene regulation by the BET inhibitor JQ1: direct activation of nuclear receptor PXR.Nucleic Acids Res2024
36848571Structure-guided approach to modulate small molecule binding to a promiscuous ligand-activated protein.Proc Natl Acad Sci U S A2023
37729916Ligand flexibility and binding pocket malleability cooperate to allow selective PXR activation by analogs of a promiscuous nuclear receptor ligand.Structure2023
34989334Regulation of immune receptor kinase plasma membrane nanoscale organization by a plant peptide hormone and its receptors.Elife2022
35426480ANGUSTIFOLIA negatively regulates resistance to Sclerotinia sclerotiorum via modulation of PTI and JA signalling pathways in Arabidopsis thaliana.Mol Plant Pathol2022
36480704Design and Optimization of 1<i>H</i>-1,2,3-Triazole-4-carboxamides as Novel, Potent, and Selective Inverse Agonists and Antagonists of PXR.J Med Chem2022
36147946Small molecule SJ572946 activates BAK to initiate apoptosis.iScience2022
36361524Neuroprotective Action of Coumarin Derivatives through Activation of TRKB-CREB-BDNF Pathway and Reduction of Caspase Activity in Neuronal Cells Expressing Pro-Aggregated Tau Protein.Int J Mol Sci2022
36262390Development of an N-Terminal BRD4 Bromodomain-Targeted Degrader.ACS Med Chem Lett2022
35978691SJPYT-195: A Designed Nuclear Receptor Degrader That Functions as a Molecular Glue Degrader of GSPT1.ACS Med Chem Lett2022
34875231Mechano-transduction via the pectin-FERONIA complex activates ROP6 GTPase signaling in Arabidopsis pavement cell morphogenesis.Curr Biol2022
34875229Arabidopsis pavement cell morphogenesis requires FERONIA binding to pectin for activation of ROP GTPase signaling.Curr Biol2022
32232515Mutation of a single amino acid of pregnane X receptor switches an antagonist to agonist by altering AF-2 helix positioning.Cell Mol Life Sci2021
33742760Identification of small molecules that mitigate vincristine-induced neurotoxicity while sensitizing leukemia cells to vincristine.Clin Transl Sci2021
33756107Membrane receptor-mediated mechano-transduction maintains cell integrity during pollen tube growth within the pistil.Dev Cell2021
33860212General Stepwise Approach to Optimize a TR-FRET Assay for Characterizing the BRD/PROTAC/CRBN Ternary Complex.ACS Pharmacol Transl Sci2021
33497575Building a Chemical Toolbox for Human Pregnane X Receptor Research: Discovery of Agonists, Inverse Agonists, and Antagonists Among Analogs Based on the Unique Chemical Scaffold of SPA70.J Med Chem2021
34707287TMK-based cell-surface auxin signalling activates cell-wall acidification.Nature2021
34485934A protocol for high-throughput screening of histone lysine demethylase 4 inhibitors using TR-FRET assay.STAR Protoc2021
34482171Biological evaluation and synthesis of calcitroic acid.Bioorg Chem2021
34215733Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma.Nat Commun2021
33314087A nonproteinaceous Fusarium cell wall extract triggers receptor-like protein-dependent immune responses in Arabidopsis and cotton.New Phytol2021
32264819Gene expression responses to anti-tuberculous drugs in a whole blood model.BMC Microbiol2020
3349090417-DMAG dually inhibits Hsp90 and histone lysine demethylases in alveolar rhabdomyosarcoma.iScience2020
31882411CITCO Directly Binds to and Activates Human Pregnane X Receptor.Mol Pharmacol2020
33458521Development of BODIPY FL VH032 as a High-Affinity and Selective von Hippel-Lindau E3 Ligase Fluorescent Probe and Its Application in a Time-Resolved Fluorescence Resonance Energy-Transfer Assay.ACS Omega2020
33128897Unlocking the mechanisms behind the formation of interlocking pavement cells.Curr Opin Plant Biol2020
33070611Development of BODIPY FL Thalidomide As a High-Affinity Fluorescent Probe for Cereblon in a Time-Resolved Fluorescence Resonance Energy Transfer Assay.Bioconjug Chem2020
33004795Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases.Nat Commun2020
32764676Auxin-induced signaling protein nanoclustering contributes to cell polarity formation.Nat Commun2020
32929340TRPM8-regulated calcium mobilization plays a critical role in synergistic chemosensitization of Borneol on Doxorubicin.Theranostics2020
32517725A blood RNA transcript signature for TB exposure in household contacts.BMC Infect Dis2020
30731240Drug discovery technologies to identify and characterize modulators of the pregnane X receptor and the constitutive androstane receptor.Drug Discov Today2019
31251562Ventromorphins: A New Class of Small Molecule Activators of the Canonical BMP Signaling Pathway.ACS Chem Biol2019
28985478Alteration of RNA Splicing by Small-Molecule Inhibitors of the Interaction between NHP2L1 and U4.SLAS Discov2018
30202030Adjunctive use of celecoxib with anti-tuberculosis drugs: evaluation in a whole-blood bactericidal activity model.Sci Rep2018
30108181Identification of Toll-like receptor signaling inhibitors based on selective activation of hierarchically acting signaling proteins.Sci Signal2018
29412999Using TR-FRET to Investigate Protein-Protein Interactions: A Case Study of PXR-Coregulator Interaction.Adv Protein Chem Struct Biol2018
29432171Regulation of <i>Arabidopsis</i> brassinosteroid receptor BRI1 endocytosis and degradation by plant U-box PUB12/PUB13-mediated ubiquitination.Proc Natl Acad Sci U S A2018
28061951Role and contribution of pulmonary CD103<sup>+</sup> dendritic cells in the adaptive immune response to Mycobacterium tuberculosis.Tuberculosis (Edinb)2017
28487681EthA/R-Independent Killing of <i>Mycobacterium tuberculosis</i> by Ethionamide.Front Microbiol2017
28436464Glucose-dependent regulation of pregnane X receptor is modulated by AMP-activated protein kinase.Sci Rep2017
28333342Activity of faropenem with and without rifampicin against Mycobacterium tuberculosis: evaluation in a whole-blood bactericidal activity trial.J Antimicrob Chemother2017
28963450SPA70 is a potent antagonist of human pregnane X receptor.Nat Commun2017
29146910An unexpected protein interaction promotes drug resistance in leukemia.Nat Commun2017
29296813Oncogenic role and therapeutic targeting of ABL-class and JAK-STAT activating kinase alterations in Ph-like ALL.Blood Adv2017
29112465High-Throughput Screening Identifies 1,4,5-Substituted 1,2,3-Triazole Analogs as Potent and Specific Antagonists of Pregnane X Receptor.Assay Drug Dev Technol2017
28739782Coadministration of Allopurinol To Increase Antimycobacterial Efficacy of Pyrazinamide as Evaluated in a Whole-Blood Bactericidal Activity Model.Antimicrob Agents Chemother2017
28684529Targeting Histone Demethylases in MYC-Driven Neuroblastomas with Ciclopirox.Cancer Res2017
28787124Ventromorphins: A New Class of Small Molecule Activators of the Canonical BMP Signaling Pathway.ACS Chem Biol2017
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Collaborators

St. Jude Children's Research Hospital
Co-authored papers 52
St. Jude Children's Research Hospital
Co-authored papers 9
St. Jude Children's Research Hospital
Co-authored papers 4
London School of Hygiene and Tropical Medicine
Co-authored papers 4
St. Jude Children's Research Hospital
Co-authored papers 4
Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 3
St. Jude Children's Research Hospital
Co-authored papers 3
Molecular Biology Institute, University of California los angeles
Co-authored papers 3
Departments of Pharmaceutical Sciences.
Co-authored papers 2
Departments of Oncology. St. Jude Children's Research Hospital
Co-authored papers 2
Sino-French Hoffmann Institute, Guangzhou Medical University
Co-authored papers 2
University of Washington
Co-authored papers 1
Department of Pharmaceutical Sciences, Utrecht University
Co-authored papers 1
St. Jude Children's Research Hospital
Co-authored papers 1
St. Jude Children's Research Hospital
Co-authored papers 1
St. Jude Children's Research Hospital
Co-authored papers 1
University of Chicago
Co-authored papers 1
Ohio State University
Co-authored papers 1
The Ohio State University
Co-authored papers 1
Changhai Hospital, Second Military Medical University
Co-authored papers 1
University of California berkeley
Co-authored papers 1
University Hospital Munster
Co-authored papers 1
Co-authored papers 1
St. Jude Children's Research Hospital
Co-authored papers 1
Mayo Clinic
Co-authored papers 1
Ohio State University
Co-authored papers 1
St Jude Children's Research Hospital
Co-authored papers 1
4Department of Pharmacy, Memphis Veterans Affairs Medical Center
Co-authored papers 1
School of Pharmacy and Pharmaceutical Sciences, University at Buffalo
Co-authored papers 1
University of California san francisco
Co-authored papers 1