Author details

Full Name

David L Brautigan

Affiliation

ORCID

Career Start Year

1973

Papers

244

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37665596	The Scaffold Protein KATNIP Enhances CILK1 Control of Primary Cilia.		2023
36239169	Phosphorylase phosphatase and flash activation of skeletal muscle glycogen phosphorylase-A tribute to Edmond H. Fischer.	IUBMB Life	2023
34794320	Renal AT Receptors Mediate Natriuresis via Protein Phosphatase PP2A.	Circulation Research	2022
35838531	Animal Models of Hepatocellular Carcinoma for Local-Regional Intraarterial Therapies.	Radiology: Imaging Cancer	2022
35897693	Modulation of Primary Cilia by Alvocidib Inhibition of CILK1.	International Journal of Molecular Sciences	2022
36416764	Transcriptome-wide association study and eQTL colocalization identify potentially causal genes responsible for human bone mineral density GWAS associations.	Elife	2022
34707113	A non-canonical, interferon-independent signaling activity of cGAMP triggers DNA damage response signaling.	Nat Commun	2021
34192314	Targeting protein phosphatase PP2A for cancer therapy: development of allosteric pharmaceutical agents.	Clin Sci (Lond)	2021
32935890	Phosphosite T674A mutation in kinesin family member 3A fails to reproduce tissue and ciliary defects characteristic of CILK1 loss of function.	Developmental Dynamics	2021
31541192	Inactivation of PP2A by a recurrent mutation drives resistance to MEK inhibitors.	Oncogene	2020
31904830	Protein kinase CK2 phosphorylation of SAPS3 subunit increases PP6 phosphatase activity with Aurora A kinase.	Biochemical Journal	2020
31848297	Aurora B Kinase Promotes CHIP-Dependent Degradation of HIF1Î± in Prostate Cancer Cells.	Molecular Cancer Therapeutics	2020
32315618	Selective PP2A Enhancement through Biased Heterotrimer Stabilization.	Cell	2020
32178256	Functional Alterations in Ciliogenesis-Associated Kinase 1 (CILK1) that Result from Mutations Linked to Juvenile Myoclonic Epilepsy.	Cells	2020
31751917	Deletion of the SAPS1 subunit of protein phosphatase 6 in mice increases radiosensitivity and impairs the cellular DNA damage response.		2020
31157564	Protein phosphatase 1Î± interacts with a novel ciliary targeting sequence of polycystin-1 and regulates polycystin-1 trafficking.	FASEB Journal	2019
30597148	High-content phenotypic assay for proliferation of human iPSC-derived cardiomyocytes identifies L-type calcium channels as targets.	J Mol Cell Cardiol	2019
31506943	Ciliogenesis associated kinase 1: targets and functions in various organ systems.	FEBS Letters	2019
31277411	Ciliopathy-Associated Protein Kinase ICK Requires Its Non-Catalytic Carboxyl-Terminal Domain for Regulation of Ciliogenesis.	Cells	2019
29377106	Modulation of GSK3Î² autoinhibition by Thr-7 and Thr-8.	FEBS Letters	2018
29925267	Protein Serine/Threonine Phosphatases: Keys to Unlocking Regulators and Substrates.	Annual Review of Biochemistry	2018
30381460	Modulation of NKG2D, NKp46, and Ly49C/I facilitates natural killer cell-mediated control of lung cancer.	Proc Natl Acad Sci U S A	2018
30278886	Selective toxicity of caffeic acid in hepatocellular carcinoma cells.	Biochemical and Biophysical Research Communications	2018
29358171	Small-Molecule Activators of Protein Phosphatase 2A for the Treatment of Castration-Resistant Prostate Cancer.	Cancer Res	2018
27872984	Cinnamic Acid Derivatives Enhance the Efficacy of Transarterial Embolization in a Rat Model of Hepatocellular Carcinoma.		2017
28504649	Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth.	J Clin Invest	2017
28941521	The Use of the Woodchuck as an Animal Model for Evaluation of Transarterial Embolization.	Journal of Vascular and Interventional Radiology	2017
28536143	Aurora Kinase A Promotes AR Degradation via the E3 Ligase CHIP.	Molecular Cancer Research	2017
28620030	Functions of protein phosphatase-6 in NF-ÎºB signaling and in lymphocytes.	Biochemical Society Transactions	2017
28444343	Lysolecithin as feed additive enhances collagen expression and villus length in the jejunum of broiler chickens.	Poultry Science	2017
28232384	The E3 Ligase CHIP Mediates p21 Degradation to Maintain Radioresistance.	Mol Cancer Res	2017
28174228	Profiling Subcellular Protein Phosphatase Responses to Coxsackievirus B3 Infection of Cardiomyocytes.	Mol Cell Proteomics	2017
26835446	Regulatory Crosstalk by Protein Kinases on CFTR Trafficking and Activity.	Frontiers in Chemistry	2016
25516960	RhoC Is an Unexpected Target of RhoGDI2 in Prevention of Lung Colonization of Bladder Cancer.	Mol Cancer Res	2015
29124187	Xanthophylls lutein and zeaxanthin modify gene expression and induce synthesis of hyaluronan in keratinocyte model of human skin.	Biochemistry and Biophysics Reports	2015
24763730	Inhibition of breast cancer metastasis suppressor 1 promotes a mesenchymal phenotype in lung epithelial cells that express oncogenic K-RasV12 and loss of p53.	PLoS ONE	2014
24362252	T-type Ca2+ channel inhibition induces p53-dependent cell growth arrest and apoptosis through activation of p38-MAPK in colon cancer cells.	Molecular Cancer Research	2014
23246967	Androgen receptor degradation by the E3 ligase CHIP modulates mitotic arrest in prostate cancer cells.	Oncogene	2014
24727471	LMTK2-mediated phosphorylation regulates CFTR endocytosis in human airway epithelial cells.	Journal of Biological Chemistry	2014
25219851	Discovery and characterization of small molecules that target the GTPase Ral.	Nature	2014
23287412	Inhibition of T-type calcium channels disrupts Akt signaling and promotes apoptosis in glioblastoma cells.	Biochemical Pharmacology	2013
22469974	PKCÎ± phosphorylation of RhoGDI2 at Ser31 disrupts interactions with Rac1 and decreases GDI activity.	Oncogene	2013
22519956	Protein Ser/Thr phosphatases--the ugly ducklings of cell signalling.		2013
23940037	The phosphatase Ptc7 induces coenzyme Q biosynthesis by activating the hydroxylase Coq7 in yeast.	Journal of Biological Chemistry	2013
24063632	Protein Ser/Thr phosphatase-6 is required for maintenance of E-cadherin at adherens junctions.	BMC Cell Biology	2013
23463002	Î±-SNAP inhibits AMPK signaling to reduce mitochondrial biogenesis and dephosphorylates Thr172 in AMPKÎ± in vitro.	Nature Communications	2013
23620404	Clinical activity and safety of combination therapy with temsirolimus and bevacizumab for advanced melanoma: a phase II trial (CTEP 7190/Mel47).	Clin Cancer Res	2013
23506001	Identification and characterization of two distinct PPP1R2 isoforms in human spermatozoa.	BMC Cell Biology	2013
23073831	Protection against the synaptic targeting and toxicity of Alzheimer's-associated AÎ² oligomers by insulin mimetic chiro-inositols.	FASEB Journal	2013
23162706	Calyculin A from Discodermia calyx is a dual action toxin that blocks calcium influx and inhibits protein Ser/Thr phosphatases.	Toxins	2012