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Author Details

Sigve Nakken
University of Oslo
2007
47
19
PMIDPaper TitleJournal TitlePublished Year
36573326screenwerk: a modular tool for the design and analysis of drug combination screens.Bioinformatics2023
37622176Chromosomal instability and a deregulated cell cycle are intrinsic features of high-risk gastrointestinal stromal tumours with a metastatic potential.Mol Oncol2023
37181409Mortality by age, gene and gender in carriers of pathogenic mismatch repair gene variants receiving surveillance for early cancer diagnosis and treatment: a report from the prospective Lynch syndrome database.EClinicalMedicine2023
35948919Clonal evolution in primary breast cancers under sequential epirubicin and docetaxel monotherapy.Genome Med2022
36428697Genetic Characterization in High-Risk Individuals from a Low-Resource City of Peru.Cancers (Basel)2022
36523963Mutational analysis and protein profiling predict drug sensitivity in multiple myeloma cell lines.Front Oncol2022
36270994The cholesterol transport protein GRAMD1C regulates autophagy initiation and mitochondrial bioenergetics.Nat Commun2022
36097178Strategies to inhibit FGFR4 V550L-driven rhabdomyosarcoma.Br J Cancer2022
33257847Risk-reducing hysterectomy and bilateral salpingo-oophorectomy in female heterozygotes of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report.Genet Med2021
33922147The Quandary of DNA-Based Treatment Assessment in De Novo Metastatic Prostate Cancer in the Era of Precision Oncology.J Pers Med2021
34046035Combining a Universal Telomerase Based Cancer Vaccine With Ipilimumab in Patients With Metastatic Melanoma - Five-Year Follow Up of a Phase I/IIa Trial.Front Immunol2021
34203177No Difference in Penetrance between Truncating and Missense/Aberrant Splicing Pathogenic Variants in <i>MLH1</i> and <i>MSH2</i>: A Prospective Lynch Syndrome Database Study.J Clin Med2021
34310709Cancer Predisposition Sequencing Reporter (CPSR): A flexible variant report engine for high-throughput germline screening in cancer.Int J Cancer2021
31337882Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database.Genet Med2020
32690931Correction: Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database.Genet Med2020
32605315Dysregulation of MITF Leads to Transformation in MC1R-Defective Melanocytes.Cancers (Basel)2020
32208873Molecularly matched therapy in the context of sensitivity, resistance, and safety; patient outcomes in end-stage cancer - the MetAction study.Acta Oncol2020
32374878Mutational dynamics and immune evasion in diffuse large B-cell lymphoma explored in a relapse-enriched patient series.Blood Adv2020
30862609Integrative genomic analysis of peritoneal malignant mesothelioma: understanding a case with extraordinary chemotherapy response.Cold Spring Harb Mol Case Stud2019
28608266Potentially pathogenic germline CHEK2 c.319+2T&gt;A among multiple early-onset cancer families.Fam Cancer2018
29991680Patterns of genomic evolution in advanced melanoma.Nat Commun2018
29458332Identification of genetic variants for clinical management of familial colorectal tumors.BMC Med Genet2018
29371908Genetic variants of prospectively demonstrated phenocopies in <i>BRCA1/2</i> kindreds.Hered Cancer Clin Pract2018
29593270Sample-Index Misassignment Impacts Tumour Exome Sequencing.Sci Rep2018
29272339Personal Cancer Genome Reporter: variant interpretation report for precision oncology.Bioinformatics2018
28754778Cancer risk and survival in <i>path_MMR</i> carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database.Gut2018
27261338Incidence of and survival after subsequent cancers in carriers of pathogenic MMR variants with previous cancer: a report from the prospective Lynch syndrome database.Gut2017
28387924High number of kinome-mutations in non-small cell lung cancer is associated with reduced immune response and poor relapse-free survival.Int J Cancer2017
28459977GSuite HyperBrowser: integrative analysis of dataset collections across the genome and epigenome.Gigascience2017
29046738Colorectal cancer incidence in <i>path_MLH1</i> carriers subjected to different follow-up protocols: a Prospective Lynch Syndrome Database report.Hered Cancer Clin Pract2017
28761742Implementing precision cancer medicine in the public health services of Norway: the diagnostic infrastructure and a cost estimate.ESMO Open2017
26657901Cancer incidence and survival in Lynch syndrome patients receiving colonoscopic and gynaecological surveillance: first report from the prospective Lynch syndrome database.Gut2017
26820768Sequencing of FTO and ALKBH5 in men undergoing infertility work-up identifies an infertility-associated variant and two missense mutations.Fertil Steril2016
25794135BRAF V600E mutation in early-stage multiple myeloma: good response to broad acting drugs and no relation to prognosis.Blood Cancer J2015
26647970A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing.Nat Commun2015
26559640Automated amplicon design suitable for analysis of DNA variants by melting techniques.BMC Res Notes2015
21914143Is the brain water channel aquaporin-4 a pathogenetic factor in idiopathic intracranial hypertension? Results from a combined clinical and genetic study in a Norwegian cohort.Acta Ophthalmol2013
21712855A mild form of Mucopolysaccharidosis IIIB diagnosed with targeted next-generation sequencing of linked genomic regions.Eur J Hum Genet2012
23251048CellLineMiner: a knowledge portal for human cell lines.Bioinformation2012
19864112Variants of the genes encoding AQP4 and Kir4.1 are associated with subgroups of patients with temporal lobe epilepsy.Epilepsy Res2010
20886615Impact of DNA physical properties on local sequence bias of human mutation.Hum Mutat2010
20213140Unstable DNA repair genes shaped by their own sequence modifying phenotypes.J Mol Evol2010
19018976ABCB4 sequence variations in young adults with cholesterol gallstone disease.Liver Int2009
19617376The disruptive positions in human G-quadruplex motifs are less polymorphic and more conserved than their neutral counterparts.Nucleic Acids Res2009
19161616Large-scale inference of the point mutational spectrum in human segmental duplications.BMC Genomics2009
19208450Effects of intronic mutations in the LDLR gene on pre-mRNA splicing: Comparison of wet-lab and bioinformatics analyses.Mol Genet Metab2009
17055652Computational prediction of the effects of non-synonymous single nucleotide polymorphisms in human DNA repair genes.Neuroscience2007
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Collaborators

Eivind Hovig
Center for Bioinformatics, University of Oslo
Co-authored papers 37
Daniel Vod??k
Institute for Cancer Research, Oslo University Hospital
Co-authored papers 15
Ola Myklebost
Institute for Cancer Research, Oslo University Hospital
Co-authored papers 9
David J Burn
Population Health Sciences Institute, Newcastle University
Co-authored papers 9
Noralane M Lindor
Mayo Clinic
Co-authored papers 5
Stephen N Thibodeau
Mayo Clinic
Co-authored papers 5
Steven Gallinger
Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto
Co-authored papers 5
Loic Le Marchand
Co-authored papers 5
Robert W Haile
Co-authored papers 4
Graham G Giles
Co-authored papers 3
Kjetil Boye
Oslo University Hospital
Co-authored papers 3
Ole Christian Lingj??rde
University of Oslo
Co-authored papers 3
Vigdis Nygaard
Institute for Cancer Research, Oslo University Hospital
Co-authored papers 2
Anne-Lise B??rresen-Dale
Institute for Cancer Research, Oslo University Hospital
Co-authored papers 2
Alfonso Urbanucci
Northwestern University Feinberg School of Medicine Chicago
Co-authored papers 2
Marit Holden
University of Mainz
Co-authored papers 1
Dirce Maria Carraro
AC Camargo Cancer Center
Co-authored papers 1
Keiran Raine
Wellcome Sanger Institute
Co-authored papers 1
David Jones
Wellcome Sanger Institute
Co-authored papers 1
Rafael Vald??s-Mas
Weizmann Institute of Science
Co-authored papers 1
Jonathan Hinton
Inivata Ltd
Co-authored papers 1
Sean M Grimmond
The University of Melbourne
Co-authored papers 1
Robert E Denroche
Ontario Institute for Cancer Research
Co-authored papers 1
John Zhang
Harvard Medical School
Co-authored papers 1
Sahil Seth
The University of Texas MD Anderson Cancer Center
Co-authored papers 1
Sveinung Gundersen
Center for Bioinformatics, University of Oslo
Co-authored papers 1
Oliver Hofmann
University of Melbourne
Co-authored papers 1
Christopher Previti
Hopp Children's Cancer Center Heidelberg (KiTZ)
Co-authored papers 1
Lawrence E Heisler
Ontario Institute for Cancer Research
Co-authored papers 1
Adam Butler
Wellcome Sanger Institute
Co-authored papers 1
Release 1.2