Author details

Full Name

Lorraine Southam

Affiliation

ORCID

Career Start Year

1996

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36662418	A Genome-Wide Association Study Meta-Analysis of Alpha Angle Suggests Cam-Type Morphology May Be a Specific Feature of Hip Osteoarthritis in Older Adults.	Arthritis Rheumatol	2023
37619450	The identification of distinct protective and susceptibility mechanisms for hip osteoarthritis: findings from a genome-wide association study meta-analysis of minimum joint space width and Mendelian randomisation cluster analyses.	EBioMedicine	2023
37034649	Multi-ancestry genome-wide study in >2.5 million individuals reveals heterogeneity in mechanistic pathways of type 2 diabetes and complications.	medRxiv	2023
37247657	Lifetime risk and genetic predisposition to post-traumatic OA of the knee in the UK Biobank.		2023
35088088	A molecular map of long non-coding RNA expression, isoform switching and alternative splicing in osteoarthritis.	Human Molecular Genetics	2022
35679866	An epigenome-wide view of osteoarthritis in primary tissues.	Am J Hum Genet	2022
35064169	Insights into the genetic architecture of haematological traits from deep phenotyping and whole-genome sequencing for two Mediterranean isolated populations.	Sci Rep	2022
34897459	Using multivariable Mendelian randomization to estimate the causal effect of bone mineral density on osteoarthritis risk, independently of body mass index.	Int J Epidemiol	2022
33055079	Genome-wide association of phenotypes based on clustering patterns of hand osteoarthritis identify <i>WNT9A</i> as novel osteoarthritis gene.	Ann Rheum Dis	2021
33903094	Linking chondrocyte and synovial transcriptional profile to clinical phenotype in osteoarthritis.	Annals of the Rheumatic Diseases	2021
33473114	Accelerating functional gene discovery in osteoarthritis.	Nat Commun	2021
34050183	Publisher Correction: Accelerating functional gene discovery in osteoarthritis.	Nat Commun	2021
33303764	Whole-genome sequencing analysis of the cardiometabolic proteome.	Nature Communications	2020
30664745	Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.	Nat Genet	2019
30576415	Very low-depth whole-genome sequencing in complex trait association studies.	Bioinformatics	2019
30762698	Erratum to: The 2018 Otto Aufranc Award: How Does Genome-wide Variation Affect Osteolysis Risk After THA?	Clinical Orthopaedics and Related Research	2019
31160809	Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.	Nat Genet	2019
30794219	The 2018 Otto Aufranc Award: How Does Genome-wide Variation Affect Osteolysis Risk After THA?	Clinical Orthopaedics and Related Research	2019
31053729	GWAS of bone size yields twelve loci that also affect height, BMD, osteoarthritis or fractures.	Nat Commun	2019
29273807	Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.	Nat Genet	2018
30405126	Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits.	Nat Commun	2018
30071838	Combination therapy as a potential risk factor for the development of type 2 diabetes in patients with schizophrenia: the GOMAP study.	BMC Psychiatry	2018
30390057	Author Correction: Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps.	Nat Genet	2018
30420737	Correction: Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa.	Mol Psychiatry	2018
30568165	Author Correction: Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits.	Nat Commun	2018
29559693	Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis.	Nat Genet	2018
29549330	Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.	Nat Genet	2018
29741735	Widespread epigenomic, transcriptomic and proteomic differences between hip osteophytic and articular chondrocytes in osteoarthritis.	Rheumatology	2018
29549329	Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.	Nat Genet	2018
29155802	Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa.	Mol Psychiatry	2018
27974301	Radiographic endophenotyping in hip osteoarthritis improves the precision of genetic association analysis.	Annals of the Rheumatic Diseases	2017
28643794	Enrichment of low-frequency functional variants revealed by whole-genome sequencing of multiple isolated European populations.	Nat Commun	2017
28552196	Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.	Am J Hum Genet	2017
28428224	Familial Hypercholesterolemia and Type 2 Diabetes in the Old Order Amish.	Diabetes	2017
28548082	Whole genome sequencing and imputation in isolated populations identify genetic associations with medically-relevant complex traits.	Nat Commun	2017
28977450	Pathways to understanding the genomic aetiology of osteoarthritis.	Hum Mol Genet	2017
28886342	A Genome-wide Association Study of Dupuytren Disease Reveals 17 Additional Variants Implicated in Fibrosis.	Am J Hum Genet	2017
29030403	New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475â¿¿000 Individuals.	Circ Cardiovasc Genet	2017
29083408	Exome-wide association study of plasma lipids in >300,000 individuals.	Nat Genet	2017
29125842	Evaluating the glucose raising effect of established loci via a genetic risk score.	PLoS One	2017
28146470	Rare and low-frequency coding variants alter human adult height.	Nature	2017
27668658	Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps.	Nat Genet	2016
27146844	Very low-depth sequencing in a founder population identifies a cardioprotective APOC3 signal missed by genome-wide imputation.	Hum Mol Genet	2016
27355579	Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.	PLoS Genet	2016
27466198	Analysis with the exome array identifies multiple new independent variants in lipid loci.	Hum Mol Genet	2016
27618447	Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension.	Nat Genet	2016
27876822	A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape.	Nat Commun	2016
26426971	The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.	PLoS Genet	2015
25631608	Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility.	Nat Commun	2015
25962519	Erratum: A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans.	Nat Commun	2015