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Author Details

Zhu Chen
Yong Loo Lin School of Medicine, National University of Singapore
1988
359
84
PMIDPaper TitleJournal TitlePublished Year
36928550A systematic survey of LU domain-containing proteins reveals a novel human gene, LY6A, which encodes the candidate ortholog of mouse Ly-6A/Sca-1 and is aberrantly expressed in pituitary tumors.Front Med2023
36980715Associations of T-Cell Receptor Repertoire Diversity with L-Asparaginase Allergy in Childhood Acute Lymphoblastic Leukemia.Cancers (Basel)2023
37441164Targeted metabolomics analysis of nucleosides and the identification of biomarkers for colorectal adenomas and colorectal cancer.Front Mol Biosci2023
36963988Thalassaemia in China.Blood Rev2023
34695195PLCG1 is required for AML1-ETO leukemia stem cell self-renewal.Blood2022
35653587Recurrent noncoding somatic and germline WT1 variants converge to disrupt MYB binding in acute promyelocytic leukemia.Blood2022
35507921Enhancing COVID-19 Epidemic Forecasting Accuracy by Combining Real-time and Historical Data From Multiple Internet-Based Sources: Analysis of Social Media Data, Online News Articles, and Search Queries.JMIR Public Health Surveill2022
35544603Functional, structural, and molecular characterizations of the leukemogenic driver MEF2D-HNRNPUL1 fusion.Blood2022
35472242Enhanced BNT162b2 vaccine-induced cellular immunity in anti-CD19 CAR T cell-treated patients.Blood2022
35860262A Novel M6A-Related Genes Signature Can Impact the Immune Status and Predict the Prognosis and Drug Sensitivity of Lung Adenocarcinoma.Front Immunol2022
35385357Transcriptome-wide subtyping of pediatric and adult T cell acute lymphoblastic leukemia in an international study of 707 cases.Proc Natl Acad Sci U S A2022
37396509The LIFR-targeting small molecules EC330/EC359 are potent ferroptosis inducers.Genes Dis2022
36442087Transcriptome-based molecular subtypes and differentiation hierarchies improve the classification framework of acute myeloid leukemia.Proc Natl Acad Sci U S A2022
36302855Targeting UHRF1-SAP30-MXD4 axis for leukemia initiating cell eradication in myeloid leukemia.Cell Res2022
36158200A direct comparison between AML1-ETO and ETO2-GLIS2 leukemia fusion proteins reveals context-dependent binding and regulation of target genes and opposite functions in cell differentiation.Front Cell Dev Biol2022
35278611Ring finger protein 6 enhances chemo-resistance by transcriptionally activating proliferating cell nuclear antigen expression and attenuating DNA damage in lung adenocarcinoma.Cancer Lett2022
32709934Yolk sac-derived Pdcd11-positive cells modulate zebrafish microglia differentiation through the NF-κB-Tgfβ1 pathway.Cell Death Differ2021
33495363Arsenic trioxide replacing or reducing chemotherapy in consolidation therapy for acute promyelocytic leukemia (APL2012 trial).Proc Natl Acad Sci U S A2021
33783994Activated factor X targeted stored in platelets as an effective gene therapy strategy for both hemophilia A and B.Clin Transl Med2021
33893160Integration of Genomic and Transcriptomic Markers Improves the Prognosis Prediction of Acute Promyelocytic Leukemia.Clin Cancer Res2021
33504140An international retrospective study for tolerability of 6-mercaptopurine on NUDT15 bi-allelic variants in children with acute lymphoblastic leukemia.Haematologica2021
34699692DNA crosslinking and recombination-activating genes 1/2 (RAG1/2) are required for oncogenic splicing in acute lymphoblastic leukemia.Cancer Commun (Lond)2021
34697290Selective and competitive functions of the AAR and UPR pathways in stress-induced angiogenesis.Cell Discov2021
34547766Distinct clinical characteristics of DUX4- and PAX5-altered childhood B-lymphoblastic leukemia.Blood Adv2021
34649996Inherent hepatocytic heterogeneity determines expression and retention of edited <i>F9</i> alleles post-AAV/CRISPR infusion.Proc Natl Acad Sci U S A2021
34078881Gata2-L359V impairs primitive and definitive hematopoiesis and blocks cell differentiation in murine chronic myelogenous leukemia model.Cell Death Dis2021
34351909Irf2bp2a regulates terminal granulopoiesis through proteasomal degradation of Gfi1aa in zebrafish.PLoS Genet2021
34207479Enhancing Influenza Epidemics Forecasting Accuracy in China with Both Official and Unofficial Online News Articles, 2019-2020.Int J Environ Res Public Health2021
34008936Regulating the Film Growth and Reducing the Defects for Efficient CsPbIBr<sub>2</sub> Solar Cells.ACS Appl Mater Interfaces2021
34196511Intra-heterogeneity in transcription and chemoresistant property of leukemia-initiating cells in murine Setd2<sup>-/-</sup> acute myeloid leukemia.Cancer Commun (Lond)2021
33997692Induced lineage promiscuity undermines the efficiency of all-trans-retinoid-acid-induced differentiation of acute myeloid leukemia.iScience2021
33216970A novel KMT2A-USO1 fusion gene-induced de novo secondary acute myeloid leukaemia in a patient initially diagnosed with acute promyelocytic leukaemia.Br J Haematol2021
32854112A PML/RARα direct target atlas redefines transcriptional deregulation in acute promyelocytic leukemia.Blood2021
31123027Interferon regulatory factor 2 binding protein 2b regulates neutrophil <i>versus</i> macrophage fate during zebrafish definitive myelopoiesis.Haematologica2020
33088589<i>setd2</i> knockout zebrafish is viable and fertile: differential and developmental stress-related requirements for Setd2 and histone H3K36 trimethylation in different vertebrate animals.Cell Discov2020
33302977Trajectory of chemical cocktail-induced neutrophil reprogramming.J Hematol Oncol2020
32747558Multidimensional study of the heterogeneity of leukemia cells in t(8;21) acute myelogenous leukemia identifies the subtype with poor outcome.Proc Natl Acad Sci U S A2020
32527650PML Nuclear Body Biogenesis, Carcinogenesis, and Targeted Therapy.Trends Cancer2020
32172487Back to the spring of 2020: facts and hope of COVID-19 outbreak.Front Med2020
32202636SETD2 deficiency accelerates MDS-associated leukemogenesis via S100a9 in NHD13 mice and predicts poor prognosis in MDS.Blood2020
32513696RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation.Proc Natl Acad Sci U S A2020
32318975Advances in COVID-19: the virus, the pathogenesis, and evidence-based control and therapeutic strategies.Front Med2020
31296582<i>In vivo</i> generated hematopoietic stem cells from genome edited induced pluripotent stem cells are functional in platelet-targeted gene therapy of murine hemophilia A.Haematologica2020
30659143Homoharringtonine deregulates <i>MYC</i> transcriptional expression by directly binding NF-κB repressing factor.Proc Natl Acad Sci U S A2019
31636956MLL is required for miRNA-mediated translational repression.Cell Discov2019
31921559Chemical Cocktail Induces Hematopoietic Reprogramming and Expands Hematopoietic Stem/Progenitor Cells.Adv Sci (Weinh)2019
31439836B1 oligomerization regulates PML nuclear body biogenesis and leukemogenesis.Nat Commun2019
31395738iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition.Proc Natl Acad Sci U S A2019
31045474International Collaboration to Save Children With Acute Lymphoblastic Leukemia.J Glob Oncol2019
30988175Exploratory trial of a biepitopic CAR T-targeting B cell maturation antigen in relapsed/refractory multiple myeloma.Proc Natl Acad Sci U S A2019
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Collaborators

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Foshan First People's Hospital
Co-authored papers 27
Peking Haidian Hospital Beijing
Co-authored papers 18
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The Affiliated Brain Hospital of Nanjing Medical University
Co-authored papers 13
Center for Trauma and Acute Care Surgery Research, Clinical Services Group
Co-authored papers 9
Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine
Co-authored papers 9
Fudan University
Co-authored papers 8
University of Bristol
Co-authored papers 8
Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine
Co-authored papers 7
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Center for Reproductive Medicine, Ren Ji Hospital, Shanghai Jiao Tong University
Co-authored papers 6
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European Institute for Systems Biology and Medicine
Co-authored papers 4
the Children's Hospital Affiliated to Xi'an Jiaotong University
Co-authored papers 4
Ningbo First Hospital, Zhejiang University
Co-authored papers 4
the Children's Hospital Affiliated to Xi'an Jiaotong University
Co-authored papers 4
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Shanghai Fifth People's Hospital, Institutes of Biomedical Sciences, Fudan University
Co-authored papers 3
The Genome Center at Washington University, Washington University School of Medicine
Co-authored papers 3
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Baylor College of Medicine
Co-authored papers 3
National Institute of Genetics
Co-authored papers 3
College of Agriculture, Guangxi University
Co-authored papers 3
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National Center for Biotechnology Information, National Institutes of Health
Co-authored papers 3
Zhejiang Provincial People's Hospital
Co-authored papers 3
Beijing Institute of Genomics, Chinese Academy of Sciences
Co-authored papers 3