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Author Details

Mark Donowitz
Johns Hopkins University School of Medicine
1974
317
75
PMIDPaper TitleJournal TitlePublished Year
37678755Calcium-sensing receptor activator cinacalcet for treatment of cyclic nucleotide-mediated secretory diarrheas.Transl Res2024
36592863Adipokine C1q/Tumor Necrosis Factor- Related Protein 3 (CTRP3) Attenuates Intestinal Inflammation Via Sirtuin 1/NF-κB Signaling.Cell Mol Gastroenterol Hepatol2023
37808771Disruption of Epithelium Integrity by Inflammation-Associated Fibroblasts through Prostaglandin Signaling: IAFs disrupt colon epithelium via PGE2-EP4.bioRxiv2023
37216099Loss of PI3k activity of inositol polyphosphate multikinase impairs PDK1-mediated AKT activation, cell migration, and intestinal homeostasis.iScience2023
37154494SLC26A3 (DRA) is stimulated in a synergistic, intracellular Ca<sup>2+</sup>-dependent manner by cAMP and ATP in intestinal epithelial cells.Am J Physiol Cell Physiol2023
37175979The Air-Liquid Interface Reorganizes Membrane Lipids and Enhances the Recruitment of Slc26a3 to Lipid-Rich Domains in Human Colonoid Monolayers.Int J Mol Sci2023
37429363A Novel Peptide Prevents Enterotoxin- and Inflammation-Induced Intestinal Fluid Secretion by Stimulating Sodium-Hydrogen Exchanger 3 Activity.Gastroenterology2023
34418586Chronic Inflammation in Ulcerative Colitis Causes Long-Term Changes in Goblet Cell Function.Cell Mol Gastroenterol Hepatol2022
35928564Identification of Intestinal NaCl Absorptive-Anion Secretory Cells: Potential Functional Significance.Front Physiol2022
35076190mOrange2, a Genetically Encoded, pH Sensitive Fluorescent Protein, is an Alternative to BCECF-AM to Measure Intracellular pH to Determine NHE3 and DRA Activity.Cell Physiol Biochem2022
35094506Has a physiologic function for NHE2 finally been identified?Acta Physiol (Oxf)2022
33074011Fluid shear stress enhances differentiation of jejunal human enteroids in Intestine-Chip.Am J Physiol Gastrointest Liver Physiol2021
34329595Patients' perspectives on the derivation and use of organoids.Stem Cell Reports2021
34288725Use of human tissue stem cell-derived organoid cultures to model enterohepatic circulation.Am J Physiol Gastrointest Liver Physiol2021
33948596SARS-COV-2 induced Diarrhea is inflammatory, Ca <sup>2+</sup> Dependent and involves activation of calcium activated Cl channels.bioRxiv2021
34048750Presentation of the AGA Distinguished Achievement Award in Basic Science to Kim E. Barrett, PhD, AGAF.Gastroenterology2021
32452833Current and potential future applications of human stem cell models in drug development.J Clin Invest2020
31933478Duodenum Intestine-Chip for preclinical drug assessment in a human relevant model.Elife2020
31818966Mechanical Stimuli Affect Escherichia coli Heat-Stable Enterotoxin-Cyclic GMP Signaling in a Human Enteroid Intestine-Chip Model.Infect Immun2020
33089106Epithelial WNT2B and Desert Hedgehog Are Necessary for Human Colonoid Regeneration after Bacterial Cytotoxin Injury.iScience2020
32601325Mucus layer modeling of human colonoids during infection with enteroaggragative E. coli.Sci Rep2020
32897876Pleiotropic ZIP8 A391T implicates abnormal manganese homeostasis in complex human disease.JCI Insight2020
32551856Cholinergic-induced anion secretion in murine jejunal enteroids involves synergy between muscarinic and nicotinic pathways.Am J Physiol Cell Physiol2020
32378997Phosphodiesterase 5 (PDE5) restricts intracellular cGMP accumulation during enterotoxigenic <i>Escherichia coli</i> infection.Gut Microbes2020
30659943cAMP Stimulates SLC26A3 Activity in Human Colon by a CFTR-Dependent Mechanism That Does Not Require CFTR Activity.Cell Mol Gastroenterol Hepatol2019
31589468Use of organoids to study regenerative responses to intestinal damage.Am J Physiol Gastrointest Liver Physiol2019
31268738Inhibition of CFTR-mediated intestinal chloride secretion as potential therapy for bile acid diarrhea.FASEB J2019
31435168Intestinal enteroids/organoids: A novel platform for drug discovery in inflammatory bowel diseases.World J Gastroenterol2019
31259744Enterotoxigenic Escherichia coli-blood group A interactions intensify diarrheal severity.J Clin Invest2019
31365292NHERF3 is necessary for <i>Escherichia coli</i> heat-stable enterotoxin-induced inhibition of NHE3: differences in signaling in mouse small intestine and Caco-2 cells.Am J Physiol Cell Physiol2019
31095706Challenges in IBD Research: Preclinical Human IBD Mechanisms.Inflamm Bowel Dis2019
31095703Challenges in IBD Research: Novel Technologies.Inflamm Bowel Dis2019
31151823Induction of the metal transporter ZIP8 by interferon gamma in intestinal epithelial cells: Potential role of metal dyshomeostasis in Crohn's disease.Biochem Biophys Res Commun2019
28882822Both NHERF3 and NHERF2 are necessary for multiple aspects of acute regulation of NHE3 by elevated Ca<sup>2+</sup>, cGMP, and lysophosphatidic acid.Am J Physiol Gastrointest Liver Physiol2018
30158152Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability.Sci Transl Med2018
29930980Molecular Basis and Differentiation-Associated Alterations of Anion Secretion in Human Duodenal Enteroid Monolayers.Cell Mol Gastroenterol Hepatol2018
30200426Enterohemorrhagic <i>E. coli</i> (EHEC)-Secreted Serine Protease EspP Stimulates Electrogenic Ion Transport in Human Colonoid Monolayers.Toxins (Basel)2018
30030371Cholera toxin inhibits SNX27-retromer-mediated delivery of cargo proteins to the plasma membrane.J Cell Sci2018
29386123Epithelial WNT Ligands Are Essential Drivers of Intestinal Stem Cell Activation.Cell Rep2018
29771685Enterotoxigenic Escherichia coli-blood group A interactions intensify diarrheal severity.J Clin Invest2018
29196502Identifying the localization and exploring a functional role for Gprc5c in the kidney.FASEB J2018
28069942A paradox of transcriptional and functional innate interferon responses of human intestinal enteroids to enteric virus infection.Proc Natl Acad Sci U S A2017
28283572PDZ domain-dependent regulation of NHE3 protein by both internal Class II and C-terminal Class I PDZ-binding motifs.J Biol Chem2017
28300206Corrigendum: Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle.Sci Rep2017
28192061The Contributions of Human Mini-Intestines to the Study of Intestinal Physiology and Pathophysiology.Annu Rev Physiol2017
28495802A common NHE3 single-nucleotide polymorphism has normal function and sensitivity to regulatory ligands.Am J Physiol Gastrointest Liver Physiol2017
28495796Phosphorylation of NHE3-S<sup>719</sup> regulates NHE3 activity through the formation of multiple signaling complexes.Mol Biol Cell2017
28345602A primary human macrophage-enteroid co-culture model to investigate mucosal gut physiology and host-pathogen interactions.Sci Rep2017
28093242The Zn<sup>2+</sup>-sensing receptor, ZnR/GPR39, upregulates colonocytic Cl<sup>-</sup> absorption, via basolateral KCC1, and reduces fluid loss.Biochim Biophys Acta Mol Basis Dis2017
28467395Erratum: A primary human macrophage-enteroid co-culture model to investigate mucosal gut physiology and host-pathogen interactions.Sci Rep2017
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Collaborators

Co-authored papers 12
Co-authored papers 7
Co-authored papers 3
Co-authored papers 2
Kidney Research Institute and Division of Nephrology, University of Washington
Co-authored papers 2
Boston Children's Hospital, Harvard Medical School
Co-authored papers 2
Co-authored papers 2
Enterin Research Institute Inc.
Co-authored papers 2
Institut Curie, PSL Research University, INSERM U1021
Co-authored papers 1
University of Alabama at Birmingham
Co-authored papers 1
Institute of Clinical Molecular Biology, Kiel University
Co-authored papers 1
Co-authored papers 1
Johns Hopkins University, Berman Institute of Bioethics
Co-authored papers 1
Co-authored papers 1
Broad Institute of MIT and Harvard
Co-authored papers 1
Berman Institute of Bioethics, Johns Hopkins University
Co-authored papers 1
Beth Israel Deaconess Medical Center RN380F
Co-authored papers 1
VA San Diego Healthcare System (VASDHS)
Co-authored papers 1
Co-authored papers 1
Henan-Macquarie University Joint Centre for Biomedical Innovation, Henan University
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1
Tokyo Medical and Dental University (TMDU)
Co-authored papers 1
Perelman School of Medicine, University of Pennsylvania
Co-authored papers 1
Co-authored papers 1
Ontario Institute for Cancer Research
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1
Icahn School of Medicine at Mount Sinai
Co-authored papers 1
Carlsberg Laboratory, Case Western Reserve University, Johns Hopkins Medicine, Johns Hopkins School of Medicine, Johns Hopkins School of Public Health, Johns Hopkins University, National Academy of Sciences, Pennsylvania State University, Presidential Commission for the Study of Bioethical Issues
Co-authored papers 1