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Author Details

Peter J Espenshade
Johns Hopkins University School of Medicine
1992
73
37
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36494027Commercial lipoprotein-deficient sera differ in iron content.Biochim Biophys Acta Mol Cell Biol Lipids2023
37967106Carbon dioxide regulates cholesterol levels through SREBP2.PLoS Biol2023
36512249Assaying Sterol-Regulated ER-to-Golgi Transport of SREBP Cleavage-Activating Protein Using Immunofluorescence Microscopy.Methods Mol Biol2023
36463977PGRMC1: An enigmatic heme-binding protein.Pharmacol Ther2023
35294526Targeting Stearoyl-CoA Desaturase in Solid Tumors.Cancer Res2022
35642642Lipid balance must be just right to prevent development of severe liver damage.J Clin Invest2022
36090151Fission yeast Dap1 heme iron-coordinating residue Y83 is required for cytochromes P450 function.MicroPubl Biol2022
33096051Dipyridamole Inhibits Lipogenic Gene Expression by Retaining SCAP-SREBP in the Endoplasmic Reticulum.Cell Chem Biol2021
34678314Progesterone receptor membrane component 1 (PGRMC1) binds and stabilizes cytochromes P450 through a heme-independent mechanism.J Biol Chem2021
33109611Serum lipoprotein-derived fatty acids regulate hypoxia-inducible factor.J Biol Chem2020
30984134Sterol Regulatory Element-Binding Protein (Sre1) Promotes the Synthesis of Carotenoids and Sterols in <i>Xanthophyllomyces dendrorhous</i>.Front Microbiol2019
28851600Oxygen-responsive transcriptional regulation of lipid homeostasis in fungi: Implications for anti-fungal drug development.Semin Cell Dev Biol2018
30241604A Scientist's Oath.Mol Cell2018
28821619Dsc E3 ligase localization to the Golgi requires the ATPase Cdc48 and cofactor Ufd1 for activation of sterol regulatory element-binding protein in fission yeast.J Biol Chem2017
28202541Coordinate Regulation of Yeast Sterol Regulatory Element-binding Protein (SREBP) and Mga2 Transcription Factors.J Biol Chem2017
29083304Prolyl dihydroxylation of unassembled uS12/Rps23 regulates fungal hypoxic adaptation.Elife2017
27053105Mga2 Transcription Factor Regulates an Oxygen-responsive Lipid Homeostasis Pathway in Fission Yeast.J Biol Chem2016
27811944Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization.Cell Res2016
27655872A Golgi rhomboid protease Rbd2 recruits Cdc48 to cleave yeast SREBP.EMBO J2016
27324795Fatostatin blocks ER exit of SCAP but inhibits cell growth in a SCAP-independent manner.J Lipid Res2016
27274088Proximity-dependent biotin labelling in yeast using the engineered ascorbate peroxidase APEX2.Biochem J2016
25771684Structure of the WD40 domain of SCAP from fission yeast reveals the molecular basis for SREBP recognition.Cell Res2015
26555169Sugar Makes Fat by Talking to SCAP.Cancer Cell2015
25918164Endoplasmic Reticulum Exit of Golgi-resident Defective for SREBP Cleavage (Dsc) E3 Ligase Complex Requires Its Activity.J Biol Chem2015
24478315Sterol regulatory element-binding protein (SREBP) cleavage regulates Golgi-to-endoplasmic reticulum recycling of SREBP cleavage-activating protein (SCAP).J Biol Chem2014
25078903Identification of candidate substrates for the Golgi Tul1 E3 ligase using quantitative diGly proteomics in yeast.Mol Cell Proteomics2014
24327658Casein kinase 1 regulates sterol regulatory element-binding protein (SREBP) to control sterol homeostasis.J Biol Chem2014
23729666Structural requirements for sterol regulatory element-binding protein (SREBP) cleavage in fission yeast.J Biol Chem2013
23760507Subunit architecture of the Golgi Dsc E3 ligase required for sterol regulatory element-binding protein (SREBP) cleavage in fission yeast.J Biol Chem2013
22086920Yeast sterol regulatory element-binding protein (SREBP) cleavage requires Cdc48 and Dsc5, a ubiquitin regulatory X domain-containing subunit of the Golgi Dsc E3 ligase.J Biol Chem2012
23000402Expanding roles for SREBP in metabolism.Cell Metab2012
22694927Regulation of lipid metabolism: a tale of two yeasts.Curr Opin Cell Biol2012
22833559Regulation of SREBP during hypoxia requires Ofd1-mediated control of both DNA binding and degradation.Mol Biol Cell2012
22681890Hierarchical modularity and the evolution of genetic interactomes across species.Mol Cell2012
22310068Identifying a static nonlinear structure in a biological system using noisy, sparse data.J Theor Biol2012
21504829Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.Mol Cell2011
22017871Regulation of the Sre1 hypoxic transcription factor by oxygen-dependent control of DNA binding.Mol Cell2011
21801748Regulation of HMG-CoA reductase in mammals and yeast.Prog Lipid Res2011
21680738Glucose controls phosphoregulation of hydroxymethylglutaryl coenzyme A reductase through the protein phosphatase 2A-related phosphatase protein, Ppe1, and Insig in fission yeast.J Biol Chem2011
21481773The hypoxic regulator of sterol synthesis nro1 is a nuclear import adaptor.Structure2011
20118213Sterol regulatory element binding proteins in fungi: hypoxic transcription factors linked to pathogenesis.Eukaryot Cell2010
20959444Ergosterol regulates sterol regulatory element binding protein (SREBP) cleavage in fission yeast.J Biol Chem2010
19158663Oxygen-dependent binding of Nro1 to the prolyl hydroxylase Ofd1 regulates SREBP degradation in yeast.EMBO J2009
19933148Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been.Genes Dev2009
19818023Cryptococcus neoformans Site-2 protease is required for virulence and survival in the presence of azole drugs.Mol Microbiol2009
19749173Conservation of the sterol regulatory element-binding protein pathway and its pathobiological importance in Cryptococcus neoformans.Eukaryot Cell2009
19520858Degradation of sterol regulatory element-binding protein precursor requires the endoplasmic reticulum-associated degradation components Ubc7 and Hrd1 in fission yeast.J Biol Chem2009
18418381Oxygen-regulated degradation of fission yeast SREBP by Ofd1, a prolyl hydroxylase family member.EMBO J2008
19041767Insig regulates HMG-CoA reductase by controlling enzyme phosphorylation in fission yeast.Cell Metab2008
18503029Identification of twenty-three mutations in fission yeast Scap that constitutively activate SREBP.J Lipid Res2008
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Collaborators

Emerson V Stewart
The Johns Hopkins University School of Medicine
Co-authored papers 8
Chris A Kaiser
Massachusetts Institute of Technology
Co-authored papers 5
Timothy F Osborne
Co-authored papers 4
David W Powell
University of Louisville School of Medicine
Co-authored papers 3
Zongtian Tong
1University of Maryland School of Pharmacy
Co-authored papers 3
Christine C Nwosu
Johns Hopkins University School of Medicine
Co-authored papers 3
Hyeseung Lee
Picower Institute for Learning and Memory, Massachusetts Institute of Technology
Co-authored papers 2
Xinqi Gong
Co-authored papers 2
Assen Roguev
University of California, USA Quantitative Biosciences Institute (QBI) san francisco
Co-authored papers 2
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 2
Ruedi Aebersold
Institute of Molecular Systems Biology, ETH Zurich
Co-authored papers 1
Jacqueline Hayles
The Francis Crick Institute
Co-authored papers 1
Timothy D Cummins
University of Louisville Louisville
Co-authored papers 1
Chad Nusbaum
Co-authored papers 1
Jiewei Xu
Quantitative Biosciences Institute (QBI), University of California san francisco
Co-authored papers 1
Rockie Chong
University of California los angeles
Co-authored papers 1
Adam Frost
University of California San Francisco
Co-authored papers 1
Hyun-Soo Kim
Wonju Severance Christian Hospital
Co-authored papers 1
Kevan M Shokat
University of California San Francisco
Co-authored papers 1
Carsten Russ
Co-authored papers 1
Chao Tang
Peking University
Co-authored papers 1
Lingli Jiang
Jiangsu University
Co-authored papers 1
Christine Guthrie
University of California san francisco
Co-authored papers 1
Dong Uk Kim
Biomedical Research Institute, Pusan National University Hospital
Co-authored papers 1
Derek Greene
University College Dublin (UCD) School of Computer Science, University College Dublin
Co-authored papers 1
Christer S Ejsing
VILLUM Center for Bioanalytical Sciences, University of Southern Denmark
Co-authored papers 1
Harlizawati Jahari
Co-authored papers 1
Elena Tosti
Albert Einstein College of Medicine
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J Peter Svensson
Karolinska Institutet
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Release 1.2